Biomedical subjects

R Giancola

Publications and source records attributed to R Giancola.

17 recordsLinked to original sources

PubMed1998

Hypotonically induced calcium increase and regulatory volume decrease in newborn rat cardiomyocytes.

The effect of cell swelling on intracellular calcium concentration ([Ca2+]i) was studied in newborn rat cardiomyocytes. Hypotonic cell swelling induced a fast and transient [Ca2+]i increase (hypotonically induced calcium increase, HICI; 388±47 nM, n=14). HICI was not inhibited by cyclopiazonic acid (CPA), an inhibitor of sarcoplasmic Ca2+-ATPase, nor ryanodine (an inhibitor of calcium-induced calcium release), whereas it was abolished (11±19 nM, n=5) in the absence of external calcium. Thus, HICI appeared to depend exclusively on entry of external calcium. Gadolinium ion (Gd3+), a generic inhibitor of stretch-activated cation channels (SACs), was unable to affect HICI (353±79 nM, n=6). Similarly, HICI was unaffected by internal Na+ depletion and external Na+ omission. These results suggest that neither Gd3+-sensitive SACs nor Na+-Ca2+ exchange is responsible for HICI. Conversely, HICI was inhibited by diltiazem (42±4 nM, n=3) and by membrane predepolarization (40±18 nM, n=5), suggesting an involvement of L-type voltage-activated calciumchannels. Cardiomyocyte swelling was followed by a regulatory volume decrease (RVD). The putative role of HICI in volume regulation was studied by removal of external calcium. This procedure significantly slowed RVD but did not abolish it. In conclusion, newborn rat cardiomyocytes exhibit an external-calcium-dependent HICI which contributes partially to the RVD.

Animals↗

PubMed1985

[A case of osteomyelitis caused by salmonella in a subject with thalassemia-drepanocytosis].

The authors show a case of osteomyelitis due to salmonella, they had the opportunity to observe in a patient suffering from thalassemia and sickle-cells disease in heterozygote from. They describe all the clinical and instrumental ascertainments performed and the surgical treatment effected at level of the osteomyelitic focus with subsequent recovery.

Anemia, Sickle Cell↗

PubMed1985

[Evaluation of the aftermath of trimalleolar fractures of the tibio-tarsal joint].

The authors have examined the follow-up of 57 cases of trimalleolar fractures treated by internal fixation. Statistics show a good end result. The Authors, moreover, report the frequent presence of synostosis tibio-fibulare distale. This condition, however, has no influence on ankle motion.

Adolescent↗

PubMed1985

[Surgical treatment of humeral epicondylitis].

The authors show the remote reviewing of 41 patients suffering from tenuis elbow, surgically treated from 1975 up to 1983. The results at the checking appear excellent in 67,4%, good in 20,9%, sufficient in 9,4% and, at last, poor in 2,3%.

Adult↗

PubMed1985

[Osteochondritis dissecans: a rare localization].

The authors show a non-frequent location of osteochondritis, occasionally diagnosed owing to a trauma. In consideration of the practically inexistent painful symptomatology, no specific therapy was performed. The clinical and radiographic checking was effected after eight months.

Adult↗

PubMed1985

[Frieberg-Kohler disease. Long-term review of the surgical treatment in 20 cases].

The authors show the reviewing of twenty patients suffering from Frieberg-Kohler's disease, surgically treated from 1975 up to 1980. The surgical intervention had been suggested by the important painful symptomatology, resisting to the conservative therapy. At checking, the patients were all satisfied with the results of operation, and could start again with their usual job.

Adolescent↗

PubMed1985

[Influence of osteoporosis on the morphology of proximal fractures of the femur].

The authors consider 100 cases of fractures of femur proximal third with the purpose to appraise the real relations existing between degree of osteoporosis and morphology of the fractures. The data obtained confirm the strict dependence of these two phenomena on each other.

Aged↗

PubMed1985

[Osseous hydatidosis: presentation of a rare localization and review of the bibliography].

The AA. present a rare case of osseus hydatidosis relapsed 27 years after the surgical treatment, located in the tibia and fibula, where the near soft tissue as well as the S.P.E. were involved. A critical revision of the bibliography is presented.

Bone Diseases↗

PubMed1985

[Review of 41 cases of surgically treated acromioclavicular dislocations].

The authors have examined the follow-up of 41 cases of acromio- clavicular dislocation, treated by internal fixation. Statistics show a very good end result.

Acromioclavicular Joint↗

PubMed1985

[Parallelism of L5-S1 in the radiological diagnosis of lumbar disk hernia].

The authors show a study about the measuring of L5-S1 angle in 100 patients with diagnosis of L5-S1 discal prolapse, confirmed by the interoperative report. The value of the angle, in 72% of cases, resulted equal to, or lower than 10, with an aggregate average of 9.45.

Adult↗

PubMed1985

[Use of the external fixator in the treatment of recent fractures of the leg].

The authors show 30 cases of recent tibial fractures treated by external fixation. They study the different types of fractures, the models of external fixation employed, the complications occurring during the treatment and the ultimate results obtained.

Adolescent↗

PubMed1985

[Dupuytren's disease and diabetes mellitus].

The AA. study the relationship between diabetes mellitus and Dupuytren's disease. The examination of 300 patients, after a palmar aponeurectomy intervention, shows a percentage of 14.3%, equivalent to 43 patients.

Adult↗

PubMed1985

[Relation between L5 sacralization and hernia of the lumbar disk].

The AA. present a study on the relationship between the most common congenital malformation of the lumbosacral passage: the sacralization of L5 and lumbar disc hernia. The examination of 200 cases of lumbar disc hernia shows a sacralization incidence of 11.5%.

Adolescent↗

PubMed1980

[Septic arthritis of the knee in adults. Treatment with closed irrigation-drainage].

The Authors report their experiences in Redon tube closed washing-drainage treatment of secondary septic arthritis in adults. This technique, used at an early stage as an alternative to needle drainage, does not require plaster immobilisation and has allowed a good residual function to be obtained. In case of absence of response to the treatment, it is considered inadvisable to persist; in such case the surgical approach with "functional treatment", and with or without combined synovectomy, is recommended.

Anti-Bacterial Agents↗

PubMed1979

[A new anti-rheumatic drug in orthopedics].

Explore the source record for details and available documents.

Adolescent↗

PubMedDate not supplied

Involvement of the membrane-bound Na,K ATPase in the evolution of experimental injuries of the spinal cord.

Rat spinal cords have been compressed at the region corresponding to D4-D5 by a 50 mg/cm force. After 5, 30 and 60 min this section has been dissected together with the surrounding cord. The ATPase activity of the homogenates was decreased, suggesting an involvement of this enzyme in the generation of edema.

Animals↗

PubMedDate not supplied

[Critical review of 2 series of Charnley-type total hip prostheses in subjects over and under 50].

The results of two series of Charnley type total hip prostheses carried out in patients above and below the age of 50 have been examined. The over-50s showed better results on the whole and a percentage of general complications comparable to that of the younger patients. The latter also reported a higher frequency of long-term peri-cemental separations.

Adult↗