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Biomedical subjects

R Glantz

Publications and source records attributed to R Glantz.

11 recordsLinked to original sources
PubMed2001

Combination of 3D MRI and connectivity analysis in structural evaluation of cancellous bone in rat proximal femur.

Three dimensional (3-D) magnetic resonance (MR) microimaging combined with connectivity analysis was tested in the study of the structure of cancellous bone. MR microimaging was performed in vitro with an average resolution of 20*20*35 microm. A 3-D connectivity analysis was used to model the trabecular bone as a network consisting of nodes and struts. Size distribution curves of these two structural elements and the interconnectivity of nodes was used to estimate the cancellous structure. The analysis suggested the occurrence of two simultaneous network structures in cancellous bone differed by the size of details. The degradative effect of ostcopenia is found to be slightly different in these two subsystems. Interconnectivity is seen to increase with the size of a node and the expected loss of connectivity due to ostcopenia is observed. The method described offers a new way in the topological estimation of interconnected medium.

Journal Article↗
PubMed1993

Respiratory dyskinesia presenting as acute respiratory distress.

Incapacitating respiratory distress was the presenting manifestation of a choreiform movement disorder. Because the patient also had asthma, respiratory distress was at first mistakenly attributed to this condition. Despite vigorous asthma management, there was no improvement. However, once the neurologic condition was recognized, use of specific therapy (haloperidol and reserpine) resulted in rapid and sustained remission of respiratory symptoms.

Adult↗
PubMed1992

Intrafamilial heterogeneity in hereditary motor neuron disease.

Although there are varied inheritance patterns in motor neuron disease (MND), the phenotype of MND is reported to be constant within these families, ie, cases of amyotrophic lateral sclerosis or primary lateral sclerosis do not occur in pedigrees with cases of spinal muscular atrophy. We describe four pedigrees whose members diverged in the phenotype of MND expressed. The intrafamilial variation of phenotype suggests a similar pathogenesis for some of the varied types of familial MND and the need for careful inquiry of family history in all patients with MND.

Aged↗
PubMed1983

Pergolide in Parkinson's disease.

Twenty-two patients received pergolide mesylate for Parkinson's disease for one year. Improvement was maximal at six months, but average functional scores were still better at 12 months than at pretreatment evaluation. On-off fluctuations were reduced in severity, and two of 18 patients experienced full resolution. Pergolide is an effective and safe ongoing medication for Parkinson's disease.

Aged↗
PubMed1982

Primary writing tremor: a selective action tremor.

Progressive difficulty in handwriting due to jerking movements precipitated by the act of writing beginning between the ages of 8 to 54 is reported in six patients. There was no rest tremor, but three had mild postural tremor. Specific muscle activity (especially pronation of the wrist or abduction of the fingers) elicited the tremors that persisted as long as the evocative posture or muscle activity was maintained. None had a family history of tremors, but two had a history suggestive of hypoxia at birth. Unlike benign essential tremor, the movements did not respond to propranolol HCl, but most patients were benefited both acutely and chronically by centrally active anticholinergic agents.

Adolescent↗
PubMed1982

Drug-induced asterixis in Parkinson disease.

Asterixis was observed in five parkinsonian patients who were taking levodopa. A prospective study revealed that 4 of 55 consecutive patients had asterixis. Liver and metabolic functions were normal in all patients. Asterixis always occurred as part of a toxic confusional state superimposed on a parkinsonian state associated with some dementia. Insomnia, hallucinosis, and myoclonus were also prominent in the affected patients. Because of this association with other signs of chronic drug toxicity and its reversal with drug withdrawal, the asterixis seemed to be drug-related.

Aged↗
PubMed1981

The effect of bromocriptine (BCT) on the on-off phenomenon.

Twenty-three patients with idiopathic Parkinson disease with classic "on-off" phenomena were studied prospectively during treatment with bromocriptine (BCT). Patients were evaluated for an average of 6 to 12 months and received an average of 56.5 mg of BCT. Nine patients (39%) showed improvement in terms of "on-off". When evaluated retrospectively, it appeared that the only difference between the responders and non-responders was a younger mean age (57.1 to 63.2).

Bromocriptine↗