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Biomedical subjects

R Goertchen

Publications and source records attributed to R Goertchen.

At least 37 records · Page 2Linked to original sources
PubMed1986

Coexistence of cytokeratin, vimentin and neurofilament protein in human choroid plexus. An immunohistochemical study of intermediate filaments in neuroepithelial tissues.

The expression of intermediate filament proteins in human brain ependyma and choroid plexus epithelium has been studied by immunohistochemistry using a panel of monoclonal antibodies directed against all five classes of intermediate filaments. Ependymal cells express GFAP and vimentin filaments, whereas plexus epithelium simultaneously contains neurofilaments, cytokeratins and vimentin, a phenomenon not previously observed in normal cells in vivo. By means of specific antibodies we were able to establish that cytokeratins 8 and 18 but not 19 are present in plexus epithelium.

Aged↗
PubMed1986

[Immunopathology of diffuse malignant mesothelioma].

A so-called diffuse biphasic pleural and a monophasic malignant "fibrous" peritoneal mesothelioma were examined using monoclonal anticytoskeleton-antibodies and polyclonal antibodies against macrophage markers. Cytokeratin, vimentin and desmin were each expressed in both of the tumors. GFAP could not be detected. In addition the tumor cells differed in the quantity of macrophage markers. The immunologic findings corresponded to the histologic features of particular areas of the carcinosarcoma. This supports the view that malignant mesotheliomas derive from pluripotential mesothelial cells capable of both epithelial and mesenchymal differentiation. Contrary to some opinions expressed in the literature this histogenesis applies equally to the so-called monophasic diffuse "fibrous" mesotheliomas.

Aged↗
PubMed1986

[Hypertonic central nervous system complications from the viewpoint of the pathologist].

Based on 2130 autopsies with a hypertension it is reported on the hypertensive CNS-lesions. The frequency of encephalomalacia was 12%. By 9.7% was founded brain haemorrhages. The relapse rate of haemorrhages was about 5%. The encephalomalacia existed by way of secondary finding in 24.7%, and the haemorrhage in 2.2%. The investigations showed an important arteriosclerosis by 39.8% in haemorrhages and by 51.6% in brain infarct. It was remarkable by the hypertensive brain haemorrhages a dominant right hemisphere.

Adolescent↗
PubMed1986

[Clinical pathology of chronic hyperplastic laryngitis. 1. The epithelial structure of the transitional zone of the larynx].

Premalignant changes of the epithelium are most likely to be first observed in the transitional zone between squamous and respiratory epithelium in the larynx. The characteristics of this region were assessed in 115 biopsies. Considerable variation was observed in the type of epithelial lining and its grade of differentiation. Two types of glandular structures were seen: small salivary glands and adenoid crypts. The latter have not previously been described in this area. Morphologically they resemble Brunn's cell nests in the urinary bladder. The epithelium of the transitional zone with its crypts and pseudocarcinomatous hyperplasia must be carefully distinguished from dysplasia.

Adult↗
PubMed1986

[Clinical pathology of chronic hyperplastic laryngitis. 2. Clinical, morphological and statistical studies with special reference to precancerous changes].

Data on 13 different clinical, histological and environmental factors were obtained from 54 patients with hyperplastic laryngitis (HL). They were evaluated by multiple linear factor analysis. HL can be considered to be a complex clinico-morphological entity. Precancerous changes in the larynx were closely correlated with the grade of HL. Etiologically only a weak association with tobacco and alcohol use could be found. The development of the disease was independent of age, sex, nasal function and of other chemical, physical or mechanical factors.

Adult↗
PubMed1984

[Chordoid sarcoma of the urinary bladder].

A case report of a chordoid sarcoma of the urinary bladder of an 81 years old man is presented. After the first description of the extraskeletal chordoid sarcoma in 1948, this is the first report of the tumor of the urinary bladder.

Aged↗
PubMed1981

[Neuropathological and morphometrical investigations on the localization of the perinatal hypoxic brain damage (author's transl)].

The localization and extent of nerve cell damage caused by perinatal hypoxia has been examined in 83 cases. In 54% of the cases nerve cell damage was localized in the medulla oblongata, in 40% the thalamus and in one third the substantia grisea centralis was affected by nerve cell necroses. In contrast to the phylogenetically older structures of CNS, nerve cell lesions occurred in our material only in 30% in the cerebral cortex and in 18% of our observation the cerebellar cortex. The results show, that the brain stem is especially vulnerable to perinatal hypoxia, this is at variance with hitherto existing conceptions. In a fourth part of the material, nerve cell damage was found in the medulla spinalis, especially in the columna anterior, After prolonged hypoxia the neuron-glia index in the lamina tecti deviates by 0.0491 from that following peracute anoxia. This caused by loss of nerve cells in the brain stem due to perinatal continuous hypoxia.

Birth Injuries↗
PubMed1979

[Leiomyomatosis of the anal canal].

The solitary occurrence of a leiomyoma in the anal channel is rarely observed. Still more infrequently is the multiple appearance of such tumours in the anal channel which is to be named leiomyomatosis. On the basis of an own observation concerning the appearance of a relapsing leiomyomatosis of the anal channel in a 66-year-old woman is reported, which hitherto has not yet been described in literature. The clinical and morphological problems of this disease are discussed.

Aged↗
PubMed1979

[The perinatal neuroglia in hypoxia. An electron- and light microscopical study with addition Golgi's impregnation (author's transl)].

The light microscopical morphology of perinatal neuroglia caused by hypoxia was examined in 60 cases, in 5 of them corresponding structures were investigated electron microscopically. The astroglia was studied additional by using the silver impregnation technique Bubenaite in 20 cases of the group. The glial lipid accumulation is a perinatal pathological process and is not related to myelination. It was found in 71,5% of the cases in astroblasts and astrocytes but seldom in oligodendrocytes. At the ultrastructural level, the lipid-loaded neuroglial cells cannot be confused with macrophages. One third of the cases showed a proliferation of the macroglial. In 20% of the cases, a focal leukodystrophy was found. A hypoxical degeneration was revealed of astrocytes by the Golgi modification of Bubenaite. The study demonstrates pathological changes of myelin formation in connection with degeneration and immature myelination. These perinatal neuroglial reactions seem to be connected with diffuse leukodystrophies. The examination gives the impression that the oligodendroglial differentiation might be disturbed. In contrast to myelin degeneration, the glial cells lesions and myelination defects play a decisive role in postnatal CNS formation.

Astrocytes↗
PubMed1979

[Electron microscopic investigations on the neuroglia in a case of postnatal hypoxia (author's transl)].

The authors report a case of a six week-old infant, who has died from postnatal brian hypoxia. The ultrastructural investigation of the neuroglia shows lipid accumulations in most of astroglia cells, but only in a few oligodendrocytes. There is no correlation between glial metamorphosis and myelinization. Furthermore, there were found an immature neuropil, disturbed myelinization, and myelin and neuropil resorption processes. The study demonstrates the important role of hypoxic glial lesions n the evolution of the brain.

Astrocytes↗
PubMed1978

[Changes of orbitofrontal astroglia in senile dementia (author's transl)].

The changes of orbitofrontal studied astroglia in 10 cases of senile dementia have been studied. The modification of Golgi-method by Bubenaite was used. The results reveal 4 different types of changed astroglia. A relation between changes of makroglia and the aging process of CNS is suggested. The changes of glia are not a result of nervous cell alterations, but an independent neuroglial process under the conditions of aging.

Aged↗
PubMed1977

[Development of current problems regarding perinatal CNS lesions from a neuropathologic viewpoint].

Perinatal central-nervous-system lesions may be found in as many as one third of all subjects who died before, during, or after the time of birth. Today, hypoxia is considered to be an essential cause of such lesions; in contrast to views held previously, birth trauma, i.e., physical injury to an infant during its delivery, is of minor pathogenetic importance. Neurohistological studies showed that it is especially prolonged hypoxia - in addition to cerebral hemorrhage, damage to the cerebral parenchyma and medullary substance - which can cause lesion of the brain stem. A relatively frequent occurrence are isolated ischemic cerebrospinal nerve cell lesions. Their prognostic dignity in regard to the possible formation of synapses and the problem of damage to the neuroglia are as yet imperfectly understood.

Asphyxia Neonatorum↗
PubMed1976

[On morphology of cerebral lesions in perinatal hypoxia (author's transl)].

From the autopsies of one year 47 brains (10 stillborns, 28 prematures and 9 newborns) were systematically examined for hypoxemic cerebral lesions. In contrast to literature findings in 75% of the cases not only veins but also arteries showed congestions and a cerebral edema due to disturbances of circulation and permeability, predominantly caused by hypoxia. Nearly half of the cases had primary leptomeningeal hemorrhages and hemorrhages in the germinal matrix tissue; stillborns had no hemorrhages in the germinal matrix. Encephalodystrophic foci were found in 17% of the cases examined. 41 of 47 brains showed single nerve cell damage with cytolysis and 8 ones a focal nerve cell decay, especially localized in the brain-stem. They were observed equally frequent in stillborne, newborns and prematures. The polyetiologic cerebral lesions point out that birth trauma does not play the dominating role in the etiology as hitherto supposed. Hypoxia gets an increasing importance. Frequently birth traumatic and hypoxemic cerebral lesions are associated.

Autopsy↗