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Biomedical subjects

R Gollhausen

Publications and source records attributed to R Gollhausen.

15 recordsLinked to original sources
PubMed1991

Allergy to coined money: nickel contact dermatitis in cashiers.

We report a 48-year-old cashier with nickel allergy and hand eczema and discuss the relevance of nickel-induced occupational hand dermatitis in cashiers. A literature review revealed that hand eczema together with nickel contact allergy is not rare in cashiers. The problems of various test results in nickel allergy and its importance in atopic eczema and in occupational dermatoses are considered. Provocative use tests are recommended to assess the relevance of patch test findings.

Dermatitis, Contact↗
PubMed1991

Photopatch testing with different ultraviolet A sources can yield discrepant test results.

A photopatch test series consisting of 27 substances was tested in 81 patients with suspected photosensitivity disorders. Irradiation was performed using the following light sources: TL-K 40W/09 bulbs (UVA'; lambda max. at 355 nm), UVASUN 5000 (UVA''; lambda max. at 375 nm), and TL 20 W/12 bulbs (UVB; lambda max. at 315 nm). One day after applying 4 sets of the test substances (D1), one test series each was exposed to 10 J/cm2 of UVA' or UVA'', or a combination of 40 mJ/cm2 UVB and 10 J/cm2 UVA''; the fourth series was left nonirradiated (control). Photopatch test reactions (PPTR) were defined as positive if there was at least an indurated erythema on D3 or later between D3 and D21 (late-onset reactions) exclusively at the irradiated, but not at the control site. At least one positive PPTR was found in 35 patients (43%), 7 of whom exhibited late-onset reactions only; in 2 cases the tests could not be read because of skin irritation. On D3, there were 44 positive reactions with UVA', only 10 of which were also demonstrable with UVA''. Twenty-one late-onset PPTR were found with UVA' and 17 with UVA''. Late-onset reactions elicited by UVA' or UVA'' mostly were concordant; divergent positive or negative results were found only in a few cases. Compared with the results obtained with UVA' or UVA'' alone, combined irradiation with UVB and UVA'' occasionally led to divergent positive as well as negative results. When photopatch test results are interpreted, it should be considered that testing with different UVA sources may yield divergent results.

Adolescent↗
PubMed1989

Reproducibility of patch test results: comparison of TRUE Test and Finn Chamber test results.

To evaluate the reproducibility of patch test results, duplicate patch test series comprising 12 allergens were simultaneously applied to either side of the back in 63 patients by the use of a newly developed patch test system, TRUE Test. When a positive test result occurred on only one side of the back, it was regarded as nonreproducible. For evaluation of the concordance of test reactions between the TRUE Test and the Finn Chamber test, the same 12 allergens mixed in petrolatum were also applied to the upper back according to the Finn Chamber technique. The reproducibility of TRUE Test results was compared with the reproducibility of the Finn Chamber test in 76 other patients. The concordance of positive reactions between the two tests was 57%, somewhat lower than in recently published studies. The percentage of nonreproducible positive results was more than twice as high with Finn Chambers, (22 of 58 positive reactions, or 37.9%) as with the TRUE Test (5 of 28 reactions, or 17.9%). However, this difference in reproducibility in the two test systems was not significant as determined by the chi 2 test (p less than 0.05).

Allergens↗
PubMed1989

Reproducibility of patch tests.

Patch tests with a series of 39 substances were performed in 41 patients on one side of the upper aspect of the back. Testing was repeated on the contralateral side of the back 1 week later (sequential testing). In 35 other patients, duplicate patch test series were simultaneously applied on both sides of the back (concomitant testing). If a positive reaction to a test substance was obtained at only one side of the back, the result was regarded as nonreproducible. Of all positive reactions, 40.0% were nonreproducible at sequential testing and 43.8% were nonreproducible at concomitant testing. Weakly positive reactions were far more often nonreproducible than stronger reactions.

Adult↗
PubMed1988

Trends in allergic contact sensitization.

A standard patch test series was tested for 7 years (1977-1983) in a total of 11,962 patients. The annual frequency of positive reactions to the compounds tested was assessed for the total and for males and females separately. During the observation period, there were significant increases in positive reactions in the total group from 6.2% to 12.7% for nickel sulphate, from 5.3% to 7.0% for balsam of Peru and from 3.8% to 6.5% for potassium dichromate, reflecting significant changes in both sexes. The frequency of positive reactions to wool alcohols, formaldehyde, neomycin sulphate, paraben mix and gentamycin sulphate significantly increased, while that of positive reactions to clioquinol, mercuric chloride and turpentine peroxide significantly decreased in either males or females, sometimes leading to significant changes in the total group.

Allergens↗
PubMed1988

[Steatocystoma multiplex conglobatum].

Two patients are described in whom steatocystoma multiplex conglobatum presented as recurrent axillary abscesses. This disease entity is rare and can easily be confused with hidradenitis suppurativa or acne conglobata.

Abscess↗
PubMed1988

[Polychondritis recidivans et atrophicans].

A typical case of chronic atrophic polychondritis with chondritis of the ear and episcleritis is presented. The inflammation subsided on treatment with colchicine. This entity is rare. It has an uncertain prognosis and causes a wide variety of symptoms. Accordingly, the spectrum of conditions that need to be considered in the differential diagnosis is also wide.

Aged↗
PubMed1987

Environmental influences on UVB erythema.

In 31 volunteers the superficial skin temperature of one forearm was either raised or lowered by a warm or cold water bath. Immediately afterwards the individual minimal erythema dose (MED) for monochromatic light of 300 +/- 5 nm (UVB) was determined on both arms. Compared to the control forearm, a warm water bath significantly lowered the MED (p less than 0.001), whereas a cold water bath had no influence on the light sensitivity. In 14 volunteers the MED for polychromatic UVB was determined on the lower back with and without a continuous cold air flow 5 min before and during the UVB exposure. The continuous cold air flow significantly increased the MED (p less than 0.05). Environmental factors such as warm water or cold air have modulating effects on UVB erythema. These interactions should be considered when dealing with the effects of natural sun exposure or phototherapy.

Adolescent↗
PubMed1985

Effects of pressure on contact dermatitis.

In human volunteers, firm pressure was applied to deformable plastic chambers containing chemical irritants, glass fibers, and selected allergens to which the subjects were sensitive. Pressure variably intensified irritant dermatitis and strikingly enhanced fiberglass dermatitis. Pressure did not influence allergic contact dermatitis. Pressure is one of several mechanical factors that can aggravate nonallergic contact dermatitis.

Allergens↗
PubMed1985

UV suppression of mast cell-mediated wealing in human skin.

Prior exposure of normal skin to subthreshold doses of UVR from a "UVA" phototherapy cabinet resulted in a small but significant reduction of the wealing response to intradermally injected codeine phosphate, a mast cell degranulating agent. The flare component of the reaction was not affected, nor were the responses to intradermally injected histamine. Both UVA and UVB from banks of filtered fluorescent tubes appeared to produce a similar but less pronounced effect. Dose-response studies revealed that the inhibition of mast cell-mediated wealing required a certain cumulative threshold dose of UVR (about 35 J/cm2 UVA + 20 mJ/cm2 UVB). The observed reduction in wealing could not be entirely explained by differences in the content of tissue histamine. It is concluded that repeated exposure to a broad range of UV wavelengths can depress the response of mast cells in vivo to degranulating agents by an unknown mechanism. This finding may have relevance to some of the observed therapeutic effects of phototherapy in certain inflammatory dermatoses and especially cutaneous mast cell disorders.

Adult↗