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R Goutier

Publications and source records attributed to R Goutier.

13 recordsLinked to original sources
PubMed1977

Modification in nucleocytoplasmic transport of RNA in vitro after whole-body X-irradiation.

Rats were sacrificed at different times after injection of 14C-orotate and liver nuclei were isolated and incubated in a cell-free system made of soluble cytoplasmic fraction from non-irradiated rat livers. The release of ribonucleoproteins from labelled nuclei to the incubation medium was measured on nuclei from normal and total-body irradiated rats (500 to 2000 R). When using short labelling times in vivo (30 min), which would label predominantly messenger-type RNP, the nuclear transport activity was depressed at early times (3 h) after whole-body irradiation, but increased at later times (24 h). When the labelling time in vivo is increased to 2 h, no significant difference was observed between control and irradiated groups. Transport of the stable ribosomal-type RNP, observed 24 h after both labelling and irradiation, was depressed. These results are discussed in view of previous personal studies on radiation effect on liver RNA synthesis and polyribosomes formation in vivo.

Animals↗
PubMed1975

Free radical evolution in rat liver following the ingestion of DAB.

The effect of the ingestion of the carcinogenic substance DAB on the density and distribution of organic free radicals in rat liver is studied by the electron spin resonance method. There is a remarkable parallelism between what is known about the evolution of the activity of mitochondria and the concentration variations of free radicals.

Animals↗