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Biomedical subjects

R Grüttner

Publications and source records attributed to R Grüttner.

At least 37 records · Page 2Linked to original sources
PubMed1982

[Excretion of methylated nucleosides in the initial therapy phase in a case of anorexia nervosa].

The urinary excretion of six methylated ribonucleosides was measured in a case of anorexia nervosa during the first eight weeks of therapy. Four phases can be distinguished. Highly elevated values are found in a clearly catabolic situation. Immediately after onset of therapy when catabolism is stopped but nutrition still inadequate the excretion of RNA-catabolites is lowered markedly. As soon as normocaloric nutrition is reached after two weeks, a short but clearcut peak-excretion can be observed. Finally, the excretion of methylated RNA-catabolites is stabilized on an intermediate level after three to six weeks, when nutrition is constantly normocaloric and weight continues to increase linearly.

Adenosine↗
PubMed1980

Protracted diarrhoea: secondary monosaccharide malabsorption and zinc deficiency with cutaneous manifestations during total parenteral nutrition.

Protracted diarrhoea in early infancy gives rise to many diagnostic and therapeutic problems. Jejunal biopsy often reveals villous atrophy of varying degrees. Severe reduction of small intestinal absorptive area causes secondary monosaccharide malabsorption, as well as secondary disaccharide deficiency, consequences which are relevant in any attempts at oral feeding. Morphologic, metabolic, endocrinological and microbiological studies have to be undertaken in order to establish a definitive diagnosis in protracted diarrhoea, but these studies often fail to reveal the aetiology of the disease. Immunologic abnormalities like phagocyte dysfunction, thymic atrophy and hypoplasia of B-cell regions in lymph nodes might be secondary events, but some types of immunodeficiency are of primary importance in the development of protracted diarrhoea. Total parenteral nutrition in many cases has to be instituted, with all its implications and hazards: septicaemia is the most dangerous of these. Zinc deficiency and acrodermatitis enteropathica may occur during total parenteral nutrition, and zinc deficiency secondarily contributes to the symptoms of diarrhoea. Parenteral administration of zinc is able to overcome these effects.

Acrodermatitis↗
PubMed1980

[Coeliac disease: clinical and pathogenic aspects (author's transl)].

Coeliac disease is a permanent food intolerance with a genetic basis which persists throughout the whole life. Ingestion of gluten proteins (wheat, rye, barley, oats) causes atrophy of the jejunal villi and, as a consequence, malabsorption. Diagnosis can only be proved by three consecutive intestinal biopsies; initially on normal diet, after 12--18 months of gluten-free diet, and after a final challenge with gluten-containing food. Biochemical changes have been discussed for a long time to be of primary importance in the pathogenesis of coeliac disease. Recently, however, evidence is increasing that immunological mechanisms are primary factors in the development of the disease. A synopsis of biochemical and immunological phenomena and of membrane receptor alterations of enterocytes and immunocytes which are genetically based is more likely to answer the question of pathogenesis than any single theory. Therapeutically, life-long gluten-free diet is necessary. In some cases, after a long course the prognosis is limited by the increased incidence of malignancy.

Celiac Disease↗
PubMed1980

[Hypothyreosis--screening in newborn (author's transl)].

Summing up, we can say that, basing on the hypothyreosis screening results obtained in the Federal Republic of Germany, a rate of 100 to 160 new hypothyreosis patients must be expected annually for every 500.000 births. Of these more than half is recognized at a time only at which irreparable damage of the central nervous system has already occurred. With the help of TSH screening, a large proportion of these patients can be saved from several mental retardation and damage, with all its severe social consequences, by enabling early institution of appropriate therapeutics measures. Hence, it would be desirable to achieve, throughout the territory of the Federal Republic, comprehensive hypothyreosis screening in combination with already introduced programme of screening in respect of metabolism, covering without exceptions all newborn and comprising responsible, rapid and efficient co-operation without "red tape", between obstetricians or midwives on the one hand and screening centers on the other.

Germany, West↗
PubMed1979

Immunofluorescent serum gliadin antibodies in children with coeliac disease and various malabsorptive disorders. I. Technique, clinical evaluation and diagnostic use of a gliadin antibody assay using pyruvic aldehyde-treated human red cells.

An immunofluorescent gliadin antibody assay is described using pyruvic aldehyde-stabilized human erythrocytes coated with gliadin. Fifty coeliac children all had high serum IgG-antigliadin titres during a normal diet or a challenge with gluten. On a gluten-free diet (30 children), titres were much lower. In patients followed-up for one year on a gluten-free diet, an initial rise in titres was followed by a slow decline. On challenge, IgG-antigliadin titres showed a slow rise or persistence at the same level in most patients. Fifty-two percent of control children with malabosrptive disorders, but without the typical "flat" mucosal lesion on jejunal biopsy, were shown to have positive titres in their sera, as were 6% of normal children and 4% of adult blood donors. The fluorescent antibody technique was compared with methods commonly used to detect wheat-protein antibodies, and was found to be superior to all of them. The immunofluorescent gliadin antibody assay appears to be useful in following-up children with coeliac disease, and in selecting patients for jejunal biopsy, although it does not replace biopsy.

Antibodies↗
PubMed1979

Shwachman's syndrome and leukaemia.

The clinical and morphological characteristics of Shwachman's syndrome (exocrine pancreatic insufficiency, pancytopenia, skeletal changes) were observed in a boy who, at the age of 8 years, developed a juvenile form of chronic myeloic leukemia which did not respond to cytostatic treatment. Autopsy revealed a striking lipomatous atrophy of the pancreas, defects in the ossification zones of the bones and marked dwarfism. In addition there was leukaemic infiltration of the pancreas, the spleen, the liver and the lymph nodes. The association of Shwachman's syndrome with leukaemia is a rare, but remarkable complication of this entity because of its relationship to the preceeding pancytopenia. Thorough follow-up of the haematological status of patients with Shwachman's syndrome is recommended.

Autopsy↗
PubMed1979

[On baby formular (author's transl)].

1. During the first months of life adapted or partially adapted formula may very well be used to feed the newborn and the young infant if breastmilk is not available. By feeding adapted milk ad libitum, overweight is avoided. This is partially due to the carbohydrate, which exclusively consists of lactose. 2. Many infants are fed "Beikost", or solid food, much too early. The best possible age is during the fourth month of life. The first solid food to be introduced into the diet of an infant should consist of meat and added vegetable. 3. Too much intake of salt and or sucrose should be avoided. 4. Between the fourth to sixth month of life one bottle per day of adapted formula should be exchanged for a "follow-up" formula instead. As follow-up formulas we prefer those without or only with a small content of sucrose.

Age Factors↗
PubMed1979

[Benign recurrent cholestasis in monozygotic twin girls (author's transl)].

The cases of Monozygotic twin girls suffering from benign recurrent familiar intrahepatic cholestasis are reported. So far both children had six icteric episodes due to this disease. These episodes occurred during times of severe emotional stress therefore, it may be assumed that a latent enzyme deficiency in the metabolism of bile acids, which is determined genetically, could be influenced by psychosomatic mechanisms. During the acute phases phenobarbital and cholestyramine succesfully reduced serum bilirubin levels.

Child↗
PubMed1978

[Isolated arterial blood vessel dysplasia in Sturge-Weber-Syndrome (author's transl)].

An 18 year old patient is reported who suffered from cerebral convulsions, originating in the right hemisphere, beginning at age fourteen. Explorative trepanation of the scull was carried out after confirmation of (1) discreet neurologic disturbances on neurologic examination in the right hemisphere, (2) focal sign on the right side in the EEG (focal slowing and focal sharp wave), and (3) a right-parietal increase of radioactive activity in the scintigram. Cerebral angiographia, insufflation encephalographia, skull x-rays and the ophthalmologic examinations were without pathologic findings. During trepanation a macroscopically typical finding of Sturge-Weber-syndrome could be demonstrated (angioma capillare et venosum) covering almost the entire right posterior hemisphere.

Adolescent↗
PubMed1976

[Advantages of breast feeding (author's transl)].

The advantages of breast feeding are due to numerous factors i.e. the favourable composition of basic nutritives, the content of nucleotides, polyamines, rare fatty acids and rare oligo- and polysaccharides in human milk, its high content of immunologically active substances like immunoglobulins, fats, glycoproteins, lysozyme and lactoferrin, and the psychologically important opportunity for close sensual contact between mother and infant. Involution of the uterus is greatly accelerated by breast feeding. In case the mother has to take certain drugs her breast feeding can be disadvantageous for the infant. At present, we do not see any reason to recommend discontinuation of breast feeding because of the relatively high DDT content found in human milk, since the concentration observed has shown no toxic effects. Furthermore a decrease of DDT concentration in human milk has been observed recently.

Breast Feeding↗