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Biomedical subjects

R Gratacos

Publications and source records attributed to R Gratacos.

7 recordsLinked to original sources
PubMed1984

Why do melanomas ulcerate?

Ulceration is an indicator of unfavourable prognosis in malignant melanoma (MM). But why do melanomas ulcerate?. Possible causes of ulceration were investigated in a group of 69 ulcerated and 69 non-ulcerated malignant melanomas. A significant correlation (P less than 0.001) between ulceration and mitotic index was found. In a group of 69 ulcerated malignant melanomas, 49 had over 7, 15 had 4-6, and only 5 had 0-3 mitotic figures per 10 high-power fields. Among 69 non-ulcerated melanomas, 28 had more than 7, 24 had 4-6, and 17 had 0-3 mitotic figures per 10 high-power fields. This study supports the hypothesis that ulceration of melanomas is usually the result of the destruction of the epidermis by the proliferating neoplastic cells or modification of blood supply due to the expansile activity of the tumor. The relationship between ulceration and mitotic activity helps clarify the prognostic significance of ulceration.

Humans↗
PubMed1984

[Immunoblastic sarcoma associated with dermatitis herpetiformis].

Association between dermatitis herpetiformis and gluten enteropathy is well established. An increased incidence of malignant disease has been reported in patients with coeliac disease and also in dermatitis herpetiformis. Linear IgA dermatitis herpetiformis has a much lower incidence of associated enteropathy compared with patients with papillary dermatitis herpetiformis, but the risk of malignancy could be the same. We report a case of linear IgA dermatitis herpetiformis in which immunoblastic sarcoma subsequently developed.

Celiac Disease↗
PubMed1982

[Lucio's leprosy].

A case of diffuse lepromatous leprosy with lepra reaction type II-Lucio's phenomenon-in a 24 years old male patient is reported. The histological examination of the necrotic lesions and of the apparently normal skin showed the presence of dense perivascular and perianexial lymphohystiocitic infiltrates with great quantities of bacilli. The first biopsy did not show a picture a leuccocytoclastic vasculitis but only areas of necrosis. The immunofluorescence studies revealed on direct examination complement deposits on vessel walls. The complement levels in blood were lowered and circulating inmunecomplexes were also detected. These data confirm the opinion that Lucio's phenomenon is caused by circulating inmunecomplexes fixed on dermal vessel walls causing skin necrotic lesions.

Adult↗
PubMed1981

[Action of 2% dexamethasone linoleate cream in various dermatoses].

A therapeutic trial with a 2% dexamethasone linoleate cream in diverse dermatosis showed very good results in 83%. The best results were recorded in toxic eczema and irritative dermatitis, contact dermatitis, psoriasis and atopic dermatitis. The tolerance was excellent in all the cases and no side effects were observed.

Adolescent↗
PubMed1981

[Parallel double-blind comparison of bazalin and desoximetasone 0.25 in neurodermatitis].

In a double-blind study on 22 patients affected by neurodermitis the action of two ointmes was studied. Both possess an activity in controlling the clinical and histological manifestations of the disease. Desoximethasone (red labelled tubes) is very usefull in controlling pruritus and, histologically, the epidermal component of the lesions. Bazalin (yellow labeled tubes containing fluocinolone acetonide 0.025%, leucobitupal 5% an salicylic acid 3%), has a higher antiscaling action a more intense activity on the dermal component of the lesions.

17-Ketosteroids↗