PubMed Health⌕ Search

Biomedical subjects

R Guendon

Publications and source records attributed to R Guendon.

14 recordsLinked to original sources
PubMed1989

[Giant tumoral hemangioma of the mediastinum. Apropos of a case].

The originality of this case report of malformed tumoral hemangioma of the mediastinum apart from its rarity (105 cases reported in the literature), concerns the patient's age (76 years old), when these tumors are predominantly observed in children and babies. The huge tumor size (800 gr), authorized the designation of giant tumor. The posterior mediastinal localization, when the usual site is in the anterior mediastinum. As in the majority of cases reported in the literature, total excision was possible. The tumor always has a benign character in the case of pure hemangioma, therefore the results are generally satisfactory.

Aged↗
PubMed1980

Prevention of bacterial respiratory infection by an association of bacterial ribosomes and membranous proteoglycans. 2. Objective assessment of the response and of the immunological stimulation.

Using a vaccine preparation administered by aerosol for respiratory anti-infectious purposes and corresponding to the original formula of ribosomes and membrane fractions of microbial germs, the authors investigated during a period of nine months whether an objective, transient or lasting stimulation of the total and specific immunoglobulin (Ig) appeared. They provide a statistical analysis based on several serum Ig measurements and demonstrate the stimulant and lasting effect of the vaccine in the production of specific Ig for a sample of patients compared with controls. In those treated they observed apparently disordered variations of the serum levels of the total Ig, which in fact correspond to the initiation of a dynamic equilibrium in relation to the immunogenicity of the vaccine, the initial level of the total Ig and the production of the specific Ig. Finally, after a booster sequence carried out five month after "primary vaccination", they established the restarting of production of specific Ig accompanied this time by a different dynamic response of the total Ig.

Adjuvants, Immunologic↗
PubMed1979

T-, B- and Fc-gamma-receptor-bearing lymphocytes in asthma.

T-, B- and Fc-gamma-receptor-bearing lymphocytes were detected using six different membrane markers in patients suffering from asthma having either normal or low serum IgA levels. E rosettes, aE rosettes and a human anti-T lymphocyte antiserum (HTLA) were used for T cell determination. In patients with low serum IgA levels E rosettes were significantly decreased. B lymphocytes were identified by EAC rosette formation and visualization of surface membrane immunoglobulins (SmIg). No significant difference was seen. Fc-gamma-receptor-bearing lymphocytes were assessed by the EA rosette assay and were significantly decreased in asthmatics with normal IgA levels. This result might be explained by the presence of immune complexes.

Adolescent↗
PubMed1978

[HLA and IgA deficiency].

The distribution of 29 HLA-A and B antigens was compared in 50 Caucasoïds with an IgA deficit and in 300 healthy controls. The patients were divided in 3 groups: 1) Partial selective IgA deficit (40); 2) Total selective Iga deficit (7); 3) IgA deficit associated with hypogammaglobulinemia (3). The patients viewed as a whole, we observed an increased frequency for the antigens HLA-Aw19, HLA-B5 and HLA-BW17. Yet, the modifications are not cleanly significant, with p less than 0.05, but p corrected not significant. We also considered the 3 groups separated and we did not remark any particular association with HLA. The data concerning HLA and congenital immune insufficiencies are reviewed. The most authors at once studied several immune defects. Only one Hungarian work was performed on IgA deficit. We do not confirm HLA-A1 and HLA-B8 increased frequencies, as it was reported, in Hungary, by Bajtai and al. There is no evident association between one HLA-A or B gene and the IgA deficit. The possible relation of IgA insufficiency with autoimmunity and allergy would justify complementary investigations, especially about HLA-D and Ia genes repartition in this disease.

Adolescent↗
PubMed1976

[Serum IgE in patients suffering from IgA deficiency with or without atopy].

Numerous studies, based upon the frequency of allergic and auto-immune disorders in association with selective deficiency in IgA, as well as the abnormally high proportion of IgA deficiency in atopic patients, have led to the hypothesis that allergy results from a deficiency in IgA during the first months of life. Thus subjects with an initial transient deficiency in IgA (followed by normal or greater than average production) produce an excess of IgE. The aim of this study, carried out by multifactorial data analysis, was to determine whether serum IgE levels were related to those of IgA. Comparison of the serum Ig levels of 4 groups of individuals, with or without IgA deficiency, showed that the production of IgE was more closely related to the respiratory condition responsible than to IgA levels. According to IgA and E levels, the 4 groups differ distinctly, atopic patients without asthma constituting a "bridge" between the control group and those with asthma. In the presence of an apparently identical situation, i.e. an IgA deficiency, individuals may react in two different ways: some produce an abundance of IgE whilst others fail to do so and are more susceptible to recurrent infective episodes. The role of the genetic control of IgE as well as environmental factors in the pathogenesis of allergic manifestations is discussed.

Age Factors↗
PubMed1975

[Role of (serum and secretory) IgA deficiency in chronic respiratory disorders. A proposal 21 cases].

The current possibility of measuring at one and the same time serum IgA and sputum SIgA, has led to precision in knowledge of IgA deficits in respiratory pathology. The authors report 21 cases detected in a group of 1000 patients (adults, adolescents and children), suffering from various chronic respiratory disorders and who had either total deficits in serum and sputum IgA (6 cases) or partial deficits (15 cases - mixed [5], serum IgA [5i1, sputum IgA [5]. In 9 cases the assoicated respiratory disorder was bronchiectasis, in 7 recurrent rhino-tracheo-bronchitis and in 5 asthma. In no cases were any extra-respiratory manifestations noted, in particular digestive disturbance or auto-immune disease. In some cases there was an associated deficit in IgE and, much less commonly, in IgG or M. Cellular immunity was not altered. The authors then discuss the place of IgA and SIgA deficitis in the pathogenesis of chronic respiratory pathology as well as their substitutive treatment using natural human immunoglobulins and the results thereof.

Adolescent↗