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Biomedical subjects

R H Brodkin

Publications and source records attributed to R H Brodkin.

At least 19 recordsLinked to original sources
PubMed1991

Cutaneous clues to renal disease.

The skin is the most visible and easily accessible organ of the body. For an astute clinician, the skin may function as an important diagnostic window to diseases affecting internal organs. This is especially true for the renal system. Chronic renal failure, regardless of its cause, often produces xerosis, pruritus, sallow hyperpigmentation, and nail changes. Half-and-half nails occur frequently in patients with renal failure and are formed of a white proximal nail portion and a normal pink distal end. Uremic frost can occur on the skin in patients with severe renal failure of long duration. This white coating on the skin is caused by an increased concentration of urea in the sweat. However, long before failure is manifested clinically, specific dermatologic abnormalities can provide clues to the cause of renal disease. We review here the hereditary, metabolic, and vascular disorders that affect both the kidney and skin. The dermatologic manifestations are stressed as important guides to the diagnosis of renal disease.

Chronic Disease↗
PubMed1990

Eruptive syringomas.

We report the case of a seventeen-year-old woman with a rare presentation of a common appendageal tumor, the eruptive syringoma. We treated her with the retinoid isotretinate, which we had hoped would result in prevention or reduction of new tumors and disappearance of pre-existing lesions. The syringomas remained stable throughout our treatment effort and new lesions continued to appear.

Adenoma, Sweat Gland↗
PubMed1990

Skin clues to medical emergencies.

In a medical emergency, when rapid diagnosis is essential, a thorough examination of the skin often provides clues to the underlying illness. Dermatologic lesions may suggest the etiology of common medical emergencies, such as coma, seizure, shock, chest pain, hemorrhage, respiratory distress, acute abdomen and acute psychosis. Since examination of the skin is rapidly and easily performed, it should be included in the evaluation of a patient with a medical emergency.

Abdomen, Acute↗
PubMed1987

Malignant disseminated porokeratosis.

A patient has been observed with a distinct form of disseminated porokeratosis. During the course of his disease, he developed changes in the porokeratosis lesions that included cellular atypia, dysplasia, and invasive squamous cell carcinoma. One of the squamous cell carcinomas produced regional and disseminated metastases, resulting in the death of the patient. Although malignancy has been previously described in the various types of porokeratosis, this is the first report of disseminated metastases and death in any form of this disease.

Carcinoma, Squamous Cell↗
PubMed1986

Septal panniculitis as a manifestation of Lyme disease.

A 22-year-old woman presented with fever, chills, photophobia, and headaches, followed by a centrally clearing erythematous skin eruption, migratory polyarthralgias, conjunctivitis, and subsequently, tender, nodular skin lesions. Antibodies to Borrelia burgdorferi were consistent with acute Lyme disease. Skin biopsy revealed acute septal panniculitis. This dermatologic manifestation has not been previously described in Lyme disease.

Adipose Tissue↗
PubMed1986

Isotretinoin in the treatment of steatocystoma multiplex: a possible adverse reaction.

A patient with steatocystoma multiplex (SM) with severe inflammation was treated with oral isotretinoin. Inflamed cysts markedly improved with treatment. However, after eight weeks of therapy, many pre-existing cysts rapidly enlarged and new cysts occurred. Therapy was then discontinued. Isotretinoin may have exacerbated or worsened this condition.

Adult↗
PubMed1985

Colonization of nonmelanocytic cutaneous lesions by dendritic melanocytic cells: a simulant of acral-lentiginous (palmar-plantar-subungual-mucosal) melanoma.

Four cases of colonization of nonmelanocytic lesions by dendritic melanocytic cells are reported, one in a verruca vulgaris of the lip, one in a squamous cell carcinoma in situ of mucous membrane overlying a tonsil, one in a lesion of lichen simplex chronicus with a nevocellular nevus of the external ear, and one in a dermatofibrosarcoma protuberans (Bednar tumor). This is an important biological process of melanocytes that must not be confused with the acral-lentiginous (palmar-plantar-subungual-mucosal (P-S-M) melanoma. It is probably much more common than the paucity of published reports would indicate.

Adult↗
PubMed1984

Cutaneous signs of dioxin exposure.

Cutaneous stigmata of exposure to the halogenated compounds, including dioxin, may be the most sensitive index of exposure. The most common skin findings include chloracne, hyperpigmentation and hirsutism. Dioxin exposure may occur in a number of ways, in industrial, military and accidental settings. The cutaneous signs of dioxin exposure should prompt a careful evaluation for associated systemic disorders.

Acne Vulgaris↗