TO-DAY'S DRUGS. TREATMENT OF THYROID DISORDERS.
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Biomedical subjects
Publications and source records attributed to R H DAVIS.
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An arginine-requiring mutant of Neurospora lacks the carbamyl phosphokinase activity present in other strains. Although carbamyl phosphate, the product of this enzyme, is required in both arginine and pyrimidine synthesis, the enzymne appears to serve only the arginine pathway. A pyrimidine specific mode of carbamyl phosphate synthesis is inferred, although it has not yet been demonstrated.
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The basis of the mutant phenotype of the pyr 3a strain of Neurospora appears to be the arginine sensitivity of an early step in pyrimidine synthesis. The effect of a suppressor mutation which renders pyr 3a pyrimidine-independent is to reduce arginine levels in the mycelium by its effect on ornithine transcarbamylase.
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