Biomedical subjects

R H Kraus

Publications and source records attributed to R H Kraus.

5 recordsLinked to original sources

PubMed2006

Ultra-low field NMR measurements of liquids and gases with short relaxation times.

Interest in nuclear magnetic resonance measurements at ultra-low magnetic fields (ULF, approximately microT fields) has been motivated by various benefits and novel applications including narrow NMR peak-width, negligible susceptibility artifacts, imaging of samples inside metal containers, and possibility of directly imaging neuronal currents. ULF NMR/MRI is also compatible with simultaneous measurements of biomagnetic signals. However the most widely used technique in ULF NMR-prepolarization at high field and measurement at lower field-results in large transient signals which distort the free induction decay signal. This is especially severe for the measurement of signals from samples and materials with short T1 time. We have devised an approach that largely cancels the transient signals. The technique was successfully used to measure NMR signals from liquids and gases with T1 in the range 1-4 ms.

Algorithms↗

PubMed2005

On concomitant gradients in low-field MRI.

Growing interest in magnetic resonance imaging (MRI) at ultra-low magnetic fields (ULF, approximately muT fields) has been motivated by several advantages over its counterparts at higher magnetic fields. These include narrow line widths, the possibility of novel imaging schemes, reduced imaging artifacts from susceptibility variations within a sample, and reduced system cost and complexity. In addition, ULF NMR/MRI with superconducting quantum interference devices is compatible with simultaneous measurements of biomagnetic signals, a capability conventional systems cannot offer. Acquisition of MRI at ULF must, however, account for concomitant gradients that would otherwise result in severe image distortions. In this paper, we introduce the general theoretical framework that describes concomitant gradients, explain why such gradients are more problematic at low field, and present possible approaches to correct for these unavoidable gradients in the context of a non-slice-selective MRI protocol.

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PubMed2004

Simultaneously detected biomagnetic signals and NMR.

We have obtained 1H NMR spectra simultaneously with high temporal resolution biomagnetic signals such as the magnetocardiogram (MCG) and magnetomyogram (MMG). The NMR spectra are acquired at measurement fields of 2-50 microT, with corresponding proton Larmor frequencies of 80-2000 Hz. Our measurements demonstrate a method suitable for MR imaging with concurrent measurement of biomagnetic signals that can provide sub-millisecond temporal resolution. The narrow line widths, reduction in susceptibility noise and enhanced spectral resolution at ultra low fields provide a new and extremely sensitive measurement method that may enable direct imaging of biological currents by detecting the phase or frequency shifts produced by magnetic fields arising from those currents. The results of our simultaneous measurements of NMR with MCG and MMG are compared to results from a current phantom to investigate the exciting potential of direct MRI of bioelectric currents.

Electrocardiography↗

PubMed2004

Noise-free magnetoencephalography recordings of brain function.

Perhaps the greatest impediment to acquiring high-quality magnetoencephalography (MEG) recordings is the ubiquitous ambient magnetic field noise. We have designed and built a whole-head MEG system using a helmet-like superconducting imaging surface (SIS) surrounding the array of superconducting quantum interference device (SQUID) magnetometers used to measure the MEG signal. We previously demonstrated that the SIS passively shields the SQUID array from ambient magnetic field noise, independent of frequency, by 25-60 dB depending on sensor location. SQUID 'reference sensors' located on the outside of the SIS helmet measure ambient magnetic fields in very close proximity to the MEG magnetometers while being nearly perfectly shielded from all sources in the brain. The fact that the reference sensors measure no brain signal yet are located in close proximity to the MEG sensors enables very accurate estimation and subtraction of the ambient field noise contribution to the MEG sensors using an adaptive algorithm. We have demonstrated total ambient noise reduction factors in excess of 10(6) (> 120 dB). The residual noise for most MEG SQUID channels is at or near the intrinsic SQUID noise floor, typically 2-3 fT Hz-1/2. We are recording MEG signals with greater signal-to-noise than equivalent EEG measurements.

Artifacts↗

PubMed2004

Forward model theoretical basis for a superconducting imaging surface magnetoencephalography system.

A novel magnetoencephalography (MEG) system was designed at Los Alamos National Laboratory (LANL) that incorporates a helmet-shaped superconductor in order to increase the signal to noise ratio. The magnetic field perturbations caused by the superconducting surface must be included in the forward physics for accurate source localization. In this paper, the theoretical basis for the forward model that calculates the field of any magnetic source in the presence of an arbitrarily shaped superconducting surface is presented. Appropriate magnetic field integral equations are derived that provide a description of the physics of the forward model. These equations are derived starting from Maxwell's equations in the presence of inhomogeneous media, with the appropriate boundary conditions for a superconductor. A discretized version of this equation is then compared with known analytic solutions for simple superconducting surface geometries.

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