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R H Luff

Publications and source records attributed to R H Luff.

21 records · Page 2Linked to original sources
PubMed1970

The effects of salicylate on temperature regulation in the rabbit.

1. A stable pyrexia has been produced in rabbits by intravenous injection of leucocyte pyrogen followed by a continuous infusion.2. Intravenous sodium salicylate, given 4 hr after the start of pyrogen infusion, induced rapid and progressive defervescence. The rate of fall of temperature was dose dependent.3. Intravenous injection of sodium salicylate had no effect on the temperature of afebrile rabbits.4. The intraventricular injection of small doses of sodium salicylate, given 4 hr after the start of a pyrogen infusion, caused a rapid, dose-dependent defervescence, but had no significant effect on the temperature of afebrile rabbits.5. Salicylates exert at least part of their antipyretic activity through an action on the central nervous system.

Animals↗
PubMed1970

Observations on the mechanism of salicylate-induced antipyresis.

1. Fever has been produced in conscious rabbits, first, by injection of leucocyte pyrogen into the lateral cerebral ventricle and, second, by local cooling of the hypothalamus.2. Both intravenous and intraventricular salicylate produce antipyresis during an established fever due to intraventricular leucocyte pyrogen. This is incompatible with the hypothesis that salicylate acts by interfering with the passage of leucocyte pyrogen from the circulation into the hypothalamus.3. Intravenous sodium salicylate has no effect on the fever due to local cooling of the hypothalamus. This suggests that salicylates do not act on central or peripheral efferent pathways involved in thermoregulation.

Animals↗