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Biomedical subjects

R H Marsh

Publications and source records attributed to R H Marsh.

13 recordsLinked to original sources
PubMed1984

Gastric emptying and drug absorption before surgery.

The rate of paracetamol absorption following oral administration has been used as a model of drug absorption and as an indirect estimate of the rate of gastric emptying before and after elective or emergency surgery in 13 adult patients. The rates of paracetamol absorption before and after surgery were not significantly different and compared well with results obtained previously in normal volunteers. This suggests that preoperative anxiety and pain did not delay gastric emptying in this group of patients.

Acetaminophen↗
PubMed1982

Syringe pump hazards.

Explore the source record for details and available documents.

Alfaxalone Alfadolone Mixture↗
PubMed1980

Recovery from pancuronium. A comparison between old and young patients.

The rate at which paralysis from pancuronium could be reversed by neostigmine was monitored in two groups of patients, one elderly and the other young adults. Some patients were found to have prolonged recovery times, and this slow reversal occurred more frequently in the older group of patients. Possible reasons for this are discussed.

Adolescent↗
PubMed1973

The effects of various time patterns of alveolar CO 2 and O 2 on breathing in man.

We have studied the responses of human arterial chemoreceptors to various patterns of quick change of stimulation. (i) Transient abolition of hypercapnia lowers VE after 2 breaths (chemoreceptor latency) only if PAO2 is low, therefore hypoxia is necessary for an arterial chemoreceptor response to CO2. (ii) Alternate breaths of euoxia and hypoxia, and of eucapnia and hypercapnia, separately and combined, have no special effect on mean V. However, oscillating CO2 commonly causes breath-by-breath alternation of V, but only if hypoxia is present; oscillating only the low O2 seldom causes oscillation of V. Concluded (a) that chemoreceptor responses to delta-CO2 are quicker than to delta-O2; (b) that, above CO2 threshold, response to rising CO2 is equal and opposite to response to falling CO2. (iii) Three time patterns of PACO2 within single respiratory cycles have been compared in hypoxia. At a single mean arterial PCO2, a small sharp fall of PACO2 early in inspiration depresses mean V, while a smaller sharp fall of PACO2 late in inspiration increases mean V. Concluded that human respiratory system distinguishes between these rather similar patterns presumably through arterial chemoreceptor pathway since the phenomenon depends on the presence of hypoxia. The importance of exact timing is emphasised.

Carbon Dioxide↗