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Biomedical subjects

R H Meyboom

Publications and source records attributed to R H Meyboom.

At least 19 recordsLinked to original sources
PubMed1992

[Liver damage caused by ranitidine].

The case history is presented of a woman who developed serious liver injury while using ranitidine (Zantac). Complete clinical recovery and normalization of liver function tests were seen after discontinuation of the drug. Since 1983 five other similar cases have been reported to the Netherlands Centre for Monitoring of Adverse Reactions to Drugs. No viral cause was found in these cases and three of the six patients used no other medication that may cause liver injury, so that a causal relationship with the use of ranitidine may be assumed. The clinical symptoms of the cases and the available literature suggest metabolic idiosyncrasy as the mechanism, most likely through an immunoallergic reaction.

Aged↗
PubMed1991

[Acute circulatory shock following administration of the non-regular enzyme preparation Wobe-Mugos].

A 54-year-old female patient was treated by a homoeopathic physician with non-orthodox enzyme therapy because of complaints pointing to multiple sclerosis. The therapy consisted of courses of German enzyme preparations (Wobe-Mugos injections, Wobenzym tablets and Wobe-Mugos suppositories), each of which lasted three weeks. During the third course the patient developed a circulatory shock immediately following an injection. She recovered successfully in hospital. On inquiry it became evident that symptoms of tightness, light-headedness and dry mouth had already occurred after a previous injection. In connection with this case a table is presented which reviews the alternative therapies that have been associated with anaphylactic or anaphylactoid reactions.

Anaphylaxis↗
PubMed1991

Adverse reaction to drugs in children, experiences with "spontaneous monitoring" in The Netherlands.

Drug use may be the cause of a wide variety of different symptoms and disorders in children and many different mechanisms may be involved. A number of situations in childhood may predispose to the development of adverse reactions. In the country-wide "voluntary reporting system" for drug monitoring in the Netherlands, only a small percentage of 4.5 of the case reports concern children (14 years and younger). The reported experiences show that adverse reactions which are important in adults, e.g. blood dyscrasia, erythema multiforme and liver injury, may also be encountered in children. The predominance of physics reactions (e.g. agitation, hallucinations) in suspected relationship with a variety of drugs (sympathicomimetics, anticholinergics, antihistamines, oxolamine) and neurological effects (e.g. dyskinesia in association with metoclopramide or domperidone) suggest that the nervous system in childhood is susceptible to side effects of drugs; further study on this subject seems to be needed. Clinical trials in children are limited because of ethical considerations; as a consequence post-marketing surveillance should pay special attention to this vulnerable group of patients. (Tab. 10, Ref. 23).

Adverse Drug Reaction Reporting Systems↗
PubMed1989

[The Halcion affair in 1979, a false alarm?].

In the course of 1979 the Netherlands Centre for Monitoring of Adverse Reactions to Drugs (NARD) received a remarkably large number of reports on patients with unusual and complex psychic disturbances, attributed to the use of the then recently marketed hypnotic triazolam. The interpretation of the data was difficult, however, and several questions could at that time not be properly answered. In the past 10 years a specific benzodiazepine withdrawal syndrome has been identified, showing many similarities with the disturbances as reported in association with triazolam. In addition similar adverse experiences with triazolam have been reported in many other countries. Tablets containing 1 mg and 0.5 mg triazolam, as were widely used in The Netherlands, have in the mean time been globally removed from the market. It is concluded that the 'triazolam syndrome' may be explained as a combination of strong benzodiazepine effects and withdrawal phenomena. The ultra short half-life of triazolam and the high doses used may have contributed to the problems as observed in The Netherlands. The signal perceived by the NARD appears to have been a valuable warning, rightly casting doubt on the safety of triazolam and the original dosage recommendations.

Drug and Narcotic Control↗
PubMed1989

[Can naproxen impair menstruation?].

Two patients are described experiencing interruption of menstrual blood flow soon after taking a tablet of naproxen (250 or 275 mg). The patients were young women (19 and 34 years) with a diagnosis of primary dysmenorrhoea: menstruation had otherwise been regular and of normal duration. Normal menstruation is influenced by prostaglandins in a complex way. Non-steroidal anti-inflammatory drugs are known to reduce the amount of blood loss in menorrhagia. It is suggested that the effects of cyclo-oxygenase inhibitors on the metabolism of prostaglandins may occasionally interfere with the normal course of menstruation.

Adult↗
PubMed1989

Hallucinations in children caused by oxolamine citrate.

Twenty reports in Australia, Belgium and The Netherlands have implicated oxolamine-citrate cough-mixtures as a cause of hallucinations in children of less than 10 years of age. Fever is not thought to be a likely alternative explanation. Similar reactions in older children and adults have not been reported and it is possible that the recommended doses for young children are too high. Information about the use of the drug in Australia suggests that such reactions are uncommon, but the information should be interpreted cautiously.

Antitussive Agents↗