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Biomedical subjects

R H Ming

Publications and source records attributed to R H Ming.

8 recordsLinked to original sources
PubMed1989

The CD4 Leu 8- T helper cell in colonic mucosa: a quantitative and functional analysis.

CD4 T cells in the colonic lamina propria are primarily B cell helper as identified by their surface phenotype CD4 Leu 8- (CD4 Leu 8+:CD4 Leu 8- ratio = 1:3.5). This is in contrast to autologous peripheral blood where CD4 Leu 8+ cells predominate (CD4 Leu 8+:CD4 Leu 8- ratio = 2.4:1). Functionally CD4 Leu 8- T cells isolated from the colon are able to provide autologous peripheral blood B cell help comparable to that of peripheral blood CD4 Leu 8- T cells. Immunoperoxidase staining of colonic tissue sections confirmed the relative lack of Leu 8 staining cells in the lamina propria and that when present these cells are located in the outer margins of lymphoid follicles.

Antigens, Differentiation↗
PubMed1988

Horse pill ("bute") hemorrhage.

Phenylbutazone (PBZ) is a nonsteroidal antiinflammatory drug (NSAID) that is not commonly prescribed due to the high incidence of serious adverse reactions. However, it is still used extensively in equine medicine, and is readily available to those employed in the care and management of horses. Such persons may take the drug indiscriminately, without medical supervision. We present a 33-year-old male race horse track worker who took phenylbutazone horse pills for a chronic toothache and subsequently suffered a major hemorrhage from a gastric ulcer. Human use of phenylbutazone horse pills should be considered by physicians confronted with patients who have upper gastrointestinal symptoms and gastric injury and who belong to this select group.

Adult↗
PubMed1987

Peripheral blood mononuclear-cell interleukin-2 production, receptor generation and lymphokine-activated cytotoxicity in inflammatory bowel disease.

The interleukin-2 pathway is essential for the normal immune response to antigen stimulation; we have examined the possibility that this may underlie abnormal peripheral blood lymphocyte immunoregulatory function that has been observed in patients with inflammatory bowel disease. We studied 11 patients with Crohn's disease and 5 with ulcerative colitis, all with quiescent disease activity. Peripheral blood mononuclear cells were isolated from these patients and from healthy age- and sex-matched controls. Interleukin-2 production after mitogen and phorbol-myristate acetate stimulation was similar in both groups: 381 +/- 71 (mean +/- SE) U/ml by control cells and 451 +/- 70 by patient cells. Interleukin-2 receptor generation was also measured pre- and poststimulation by labeling with anti-Tac antibody. This was 10.45 +/- 1 and 69.95 +/- 3.85% for control cells and 11.41 +/- 1.38 and 60.9 +/- 4.25% for patients cells. Finally, we examined the response of these cells to interleukin-2 stimulation by generating cells with direct cytotoxicity to 51Cr-labeled Daudi-cell targets. Control cells caused 59.5 +/- 46% 51Cr release, whereas patient cells caused 50.8 +/- 5.18% release. None of the above results achieved statistical significance. We conclude that the peripheral blood interleukin-2 pathway is normal in inactive inflammatory bowel disease.

Cells, Cultured↗
PubMed1986

Hepatic hydrothorax is a relative contraindication to chest tube insertion.

Two patients with known chronic ascites developed new massive right-sided pleural effusions. Chest tube placement led to massive protein and electrolyte depletion and death of both patients. Patients who have cirrhosis and massive right-sided pleural effusions, in general, have congenital diaphragmatic defects that predispose them to life-threatening fluid depletion when chest tubes are inserted. Hepatic hydrothorax is a relative contraindication to chest tube insertion.

Adult↗
PubMed1982

Thyrotoxicosis presenting as dysphagia. A case report.

Thyrotoxicosis may manifest with dysphagia. The case of an elderly male with dysphagia as the initial symptom is discussed. It is suggested that thyrotoxicosis is included in the differential diagnosis of dysphagia in the elderly, particularly if muscle weakness is also present.

Aged↗
PubMed1982

Pancreatic abscess and computed tomographic scanning.

A 42-year-old man presented with acute haemorrhagic pancreatitis. He developed all the major complications of acute pancreatitis including a pancreatic abscess which was shown to progress on serial computed tomography (CT) scans. The diagnostic value of CT in acute pancreatitis is emphasized.

Abscess↗