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Biomedical subjects

R H Prince

Publications and source records attributed to R H Prince.

11 recordsLinked to original sources

Dissipative enhancement of the response of a bistable noisy oscillator to external driving.

A study of the linear response susceptibility of a noisy bistable oscillator as a function of damping is carried out using the method of moments. It is found that this dependence, counterintuitively, has a nonmonotonic character and shows a maximum when the driving frequency is comparable to the thermal interwell hopping rate. The possible mechanism responsible for the occurrence of such dissipative sensitivity enhancement is proposed.

Journal Article↗

Transcultural psychiatry: personal experiences and Canadian perspectives.

In the mid-1950s, a unique section of transcultural psychiatric studies was established within the McGill Department of Psychiatry. These personal recollections describe the backgrounds, methods, and motivations of those most involved and suggest why such a specialized study should have emerged in Canada and at McGill. Some of the major controversies and developments in the field are explored, focusing on the question of culture-bound syndromes and their occasional biological underpinnings. The relevance of transcultural psychiatry to psychiatric practice is discussed.

Anorexia Nervosa↗

Randomised trial of home-based psychosocial nursing intervention for patients recovering from myocardial infarction.

BACKGROUND: Increases in life stress have been linked to poor prognosis, after myocardial infarction (MI). Previous research suggested that a programme of monthly screening for psychological distress, combined with supportive and educational home nursing interventions for distressed patients, may improve post-MI survival among men. Our study assessed this approach for both men and women. We aimed to find out whether the programme would reduce 1-year cardiac mortality for women and men. METHODS: We carried out a randomised, controlled trial of 1376 post-MI patients (903 men, 473 women) assigned to the intervention programme (n = 692) or usual care (n = 684) for 1 year. All patients completed a baseline interview that included assessment of depression and anxiety. Survivors were also interviewed at 1 year. FINDINGS: The programme had no overall survival impact. Preplanned analyses showed higher cardiac (9.4 vs 5.0%, p = 0.064) and all-cause mortality (10.3 vs 5.4%, p = 0.051) among women in the intervention group. There was no evidence of either benefit or harm among men (cardiac mortality 2.4 vs 2.5%, p = 0.94; all-cause mortality 3.1 vs 3.1%, p = 0.93). The programme's impact on depression and anxiety among survivors was small. INTERPRETATION: Our results do not warrant the routine implementation of programmes that involve psychological-distress screening and home nursing intervention for patients recovering from MI. The poorer overall outcome for women, and the possible harmful impact of the intervention on women, underline the need for further research and the inclusion of adequate numbers of women in future post-MI trials.

Aged↗

Psychiatry and the irrational: does our scientific world view interfere with the adaptation of psychotics?

Perhaps even more strongly than others in our contemporary Western world, psychiatrists cling to an exceptionally rigid scientific world view. When psychotic patients speak of such matters as their experiences with spirits or of being possessed or of their preoccupations with meaningful coincidences, psychiatrists discount their views as mere psychotic delusions. We suggest that psychiatrists should deal with their patient's attempts at explaining their symptoms by negotiation and compromise, just as any other physician would do when confronted with patient explanations for symptoms which do not coincide with the tenets of scientific medicine. Rather than relegating the psychotic to a meaning-vacuum by dismissing his or her explanations as totally false and non-negotiable, the therapist should help patients find meaning by linking their views and experiences to those of important thinkers within Western cultures. Almost all elements of psychotic thought including beliefs in disembodied spirits, synchronicity (meaningful coincidences), and the possibility of non-material, actions-at-a-distance can be found among respected Western philosophers, psychiatrists, religious leaders and quantum physicists. An example of the world view of a psychotic patient is presented in which a variety of idiosyncratic beliefs are described including convictions of the reality of synchronicity. We demonstrate that highly similar synchronicity beliefs have been entertained by many major Western intellectuals. We contend that on this basis and along with negotiation and compromise, a therapeutic alliance can be established which may provide a measure of symptom relief as well as improvements in rehabilitation potential.

Cultural Characteristics↗

EPR spectroscopy of the iron-sulphur cluster and sirohaem in the dissimilatory sulphite reductase (desulphoviridin) from Desulphovibrio gigas.

Desulphoviridin in the oxidized state showed EPR signals around g = 6, consistent with the sirohaem being in the high-spin ferric state. This was unreactive with sulphite, sulphide or cyanide; but readily reduced by methyl viologen. When the enzyme was treated with Na2S2O4 the sirohaem was slowly reduced and a spectrum of a reduced iron-sulphur cluster at g = 2.07, 1.93, 1.91 appeared over the course of an hour. An intermediate in this reaction was indicated by a free radical signal which appeared within seconds and then gradually disappeared. On treatment with nitrite and reduced methyl viologen, the enzyme gave a spectrum of a nitroxide derivative similar to that seen with plant nitrite reductase. The midpoint reduction potential of the haem was estimated to be -310 mV or less. The iron-sulphur cluster has a very low potential, being only reduced in the presence of free Na2S2O4 around -560 mV. Desulphoviridin can be classed with sirohaem-containing iron-sulphur proteins.

Binding Sites↗

Middle income, divorced female heads of families: their lifestyles, health and stress levels.

Forty-five, French-Canadian female heads of families with adequate incomes and high educational levels were identified through newspaper ads. At time of interview, the subjects had been separated or divorced for from one to three years. Interviews showed that, unlike previous reports of divorced women and female heads of families, this group enjoyed relatively good health and normal stress levels, and were generally positive about being head of the family. Among the positive changes, the majority emphasized their greater autonomy, freedom, and sense of selfhood. Some mentioned improved relations with their children. On the negative side, loneliness, absence of the father (particularly for their sons), and limited social lives were most often mentioned. It was concluded that the role of head of family is perfectly acceptable for many economically viable women, though not necessarily ideal.

Adult↗

[Stress and prevention in the recurrence of coronary heart disease.].

A good deal of recent research suggests that a period of mounting life stress is a precursor of many physical illnesses, including episodes of coronary heart disease (CHD). It should be possible then, by monitoring levels of stress to predict when a high risk individual is likely to suffer a further illness episode, and in some cases to prevent the episode by alleviating stress producing problems. Based on this concept, we have telephone-monitored (at monthly intervals) 37 CHD patients discharged from the coronary unit of the Montreal General Hospital. Stress was measured using a 20-item, self-report scale (Goldberg), and charted for each patient over a seven month period. When a patient's stress rose above a critical level he received a home visit by the project nurse, who investigated his problems and attempted to alleviate them. Interventions varied from simple reassurance to referral for psychiatric treatment or legal aid. Monitoring stress in this way revealed a picture remarkably like the theoretical model. None of the 15 consistently low-scoring patients required rehospitalization. Eleven patients had low scores at the time of discharge, but their scores rose above the critical level in subsequent months. Nine of them responded in a gratifying way- to the home visit and subsequent intervention by the nurse, and none required rehospitalization. The one patient of this type who did require hospitalization had not received a home visit because no nurse was available at the time. Four of the nine patients with consistently high scores required eight rehospitalization s for CHD episodes. These patients seemed to be chronically stressed, and often required continuous support from the nurse. Our study suggests that life stress may be more important than the traditional physical risk factors (obesity, smoking, hypertension, family history of CHD, lack of exercise) in the etiology of recurrent CHD when patients receive adequate medical care. Some of our findings suggest that the nurse's interventions do reduce rehospitalizations, but a large scale controlled study is called for. We conclude that this technique is worth further evaluation, both as a research method and as a practical device for the prevention of rehospitalization of CHD patients and of other types of episodic illnesses.

English Abstract↗