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Biomedical subjects

R H Reindollar

Publications and source records attributed to R H Reindollar.

43 records · Page 3Linked to original sources
PubMed1983

Adolescent menstrual disorders.

The adolescent years present a vulnerable period of time during which menstrual abnormalities may arise. These abnormalities may be related to the maturational processes of the neuroendocrine, gonadal, and anatomic components of the reproductive system. Adolescent menstrual disorders may be totally unrelated to these maturational changes or may occur after puberty is completed. Manifestation of pubertal and nonpubertal conditions is variable. Most patients with aberrations of puberty present with amenorrhea, and most adolescents with disorders unrelated to puberty present with abnormal bleeding. However, amenorrhea and bleeding problems may occur in both groups of patients. All adolescents with menstrual disorders must be treated aggressively because of the known association with these conditions and poor outcome. Morbidity, mortality, and reduced reproductive potential have been demonstrated for all such adolescents.

Adolescent↗
PubMed1983

Recurrent abortion.

The causes of recurrent reproductive failure are diverse. Many of them are not evident in routine clinical practice and some are still unknown to sophisticated researchers in the field of reproduction. A rational clinical evaluation of the couple will identify the known causes and suggest the unknown causes. More recently the unknown causes have been further classified because of advances in cytogenetic techniques. Abortion material can now be divided into aneuploid and euploid conditions. Heteromorphic banding techniques are useful in exploring both the parental source and the mechanism responsible for recurrent aneuploidy. Delays in ovulation and fertilization may be closely linked to these cytogenetic errors. Identification of euploid abortuses in this unknown group will allow for diagnosis of endocrine, immunologic, and teratologic causes yet to be discovered. With identification of known causes, the treatment is clear cut. All other couples are at the present time dependent upon the availability of techniques to identify unknown causes. Treatment must center on normalization of ovulation, synchronization of sperm deposition and ovulation, and optimization of the maternal environment in which fertilization will occur for these couples of unknown causes.

Abortion, Habitual↗
PubMed1982

Ultrasonic placental localization in relation to spontaneous abortion after mid-trimester amniocentesis.

This paper summarizes our experience with a series of 562 women referred for mid-trimester amniocentesis for prenatal diagnosis. Ultrasonography was utilized for placental localization. Follow-up revealed a fetal loss rate of 3.03 per cent with 1.96 per cent being spontaneous abortions. Patients with an anterior placenta had a fetal loss and spontaneous abortion rate of 4.06 per cent and 3.05 per cent, respectively. No significant difference in the incidence of fetal loss (p greater than 0.1) or spontaneous abortion (p greater than 0.5) was found in patients having an anterior versus a posterior placenta. Neither multiple insertions through an anterior placenta nor blood contaminated amniotic fluid from patients with an anterior placenta were associated with an increased incidence of fetal loss or spontaneous abortion.

Abortion, Spontaneous↗
PubMed1982

Use of restriction endonucleases for mapping the allele for beta s-globin.

We have reported the direct analysis of the allele for beta 2-globin by using restriction endonuclease Dde I coupled with blot-hybridization analysis. In that report we predicted that a major use of our analysis could be for the prenatal diagnosis of sickle cell anemia. Here we present such an analysis. In addition, this report also describes the use of a new enzyme Mst II, which also distinguish the beta s allele from the normal beta-globin allele. Blot-hybridization analysis with restriction endonuclease Mst II shows the 5' end of the normal beta-globin gene to reside on a fragment of approximately 1.14 kilobases, whereas the 5' end of the beta s-globin gene resides on a fragment of approximately 1.34 kilobases. Because the fragment sizes generated by Mst II are significantly larger than those generated by Dde I, one can easily perform a prenatal diagnosis for sickle cell by standard blot hybridizations onto nitrocellulose filters.

Amniotic Fluid↗
PubMed1981

Delayed sexual development: a study of 252 patients.

A series of 252 patients with abnormalities of pubertal development are reported. Ovarian failure, followed by Rokitansky syndrome and then physiologic delay, are the most frequently encountered etiologies. Other etiologies are diverse and numerically less frequent. The average age of presentation, patient's height, somatic anomalies, diagnostic errors, and subsequent reproductive potential of each diagnostic group are reported. Only 35 (14%) of all patients presenting with abnormalities of pubertal development had subsequent normal reproductive potential. All of these patients were in the physiologic delay category.

Adolescent↗