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Biomedical subjects

R H Richards

Publications and source records attributed to R H Richards.

35 records · Page 2Linked to original sources
PubMed1992

Observations on removal of metal implants.

A total of 86 adult patients who underwent routine surgery to remove metal internal fixation devices were studied prospectively. At the time of surgery, 46 patients were symptomatic, but only 27 requested surgery; 59 were admitted for routine surgery on medical advice. There was no correlation between symptoms, the length of time the implant had been in situ or the location of the implant. Good results were achieved in 91 per cent of symptomatic patients and no problems occurred in 95 per cent of asymptomatic cases. Overall there was a 3 per cent complication rate including one refracture, one radial nerve injury and one haematoma. No wound infections occurred. Potential difficulties in the removal of implants and possible risks of retained implants are discussed, relating to refracture, osteopenia, metal toxicity and neoplasia. In conclusion, it may be appropriate to leave asymptomatic implants in situ, except for femoral and tibial diaphyseal plates.

Adolescent↗
PubMedDate not supplied

Septic arthritis caused by Corynebacterium xerosis following vascular surgery.

A case of septic arthritis due to Corynebacterium xerosis occurred after vascular surgery and was successfully treated with intravenous cefotaxime followed by oral erythromycin. The only previously reported case of C. xerosis arthritis developed in a patient with a history of similar recent surgery. The possible association of this infection with such a postsurgical setting is discussed.

Aged↗
PubMedDate not supplied

Acetate levels in human plasma.

We have developed a gas liquid chromatographic assay for plasma acetate which detects 0.01 mM and has a standard deviation of less than 16% of the mean at 0.05 mM. The acetate concentration of venous blood obtained from normal subjects was 0.025 +/- 0.002 mM. The value was not significantly different from the venous acetate concentration of dialysis patients, prior to a dialysis treatment. The acetate concentration of arterial plasma obtained from dialysis patients prior to a hemodialysis treatment was 0.048 +/- 0.006 mM. This was significantly greater than the venous concentration of 0.027 +/- 0.002 (p less than 0.01). This arteriovenous difference suggests that acetate is utilized peripherally. At the onset of hemodialysis, acetate concentrations rapidly rose and, in all but one case, reached a steady state value in the range of 1.5-5.1 mM. At the termination of dialysis, acetate concentrations fell rapidly, usually achieving baseline values within one hr. The rate of decrease was not a simple logarithmic function, suggesting that acetate metabolism is not solely a first order function. Furthermore, acetate disappearance was more rapid in the dialysis patients than in the normal subjects. We wish to emphasize that the present data, which were obtained on a small number of subjects are preliminary and should be interpreted with caution.

Acetates↗
PubMedDate not supplied

Amoxicillin concentrations in the serum of Atlantic salmon (Salmo salar L) during furunculosis therapy.

The effectiveness of the delivery of amoxicillin to Atlantic salmon, undergoing chemotherapy in natural outbreaks of furunculosis in sea-cages, was investigated by measuring the concentration of the drug in serum samples. Five groups of 50 sera from three outbreaks were collected two hours after oral treatment with doses of 80 or 120 mg/kg bodyweight. Amoxicillin was detected in 82, 82, 92, 100 and 90 per cent of the sera in the five groups (limit of detection 0.16 microgram/ml). Many sera contained less than the minimum inhibitory concentration of amoxicillin for the causative agent Aeromonas salmonicida (0.3 microgram/ml), but a concentration more than double the minimum inhibitory concentration was achieved in 2, 2, 56, 32 and 44 per cent of the samples. There was wide variation in the serum concentrations between individuals in the same population and between populations receiving the same treatment; this variation was associated with population factors, the severity of infection and the accuracy of medicating the feed.

Aeromonas↗