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Biomedical subjects

R H Riddell

Publications and source records attributed to R H Riddell.

At least 109 records · Page 6Linked to original sources
PubMed1981

Peritoneal malignant mesothelioma in a patient with recurrent peritonitis.

A patient is presented who developed a peritoneal malignant mesothelioma in association with severe persistent and recurrent diverticulitis. The case is unusual in that a spectrum of mesothelial proliferation was documented beginning initially as benign foci of mesothelial proliferation and passing through a stage of atypical proliferation before terminating as a malignant process. The possible role of the diverticular disease in the pathogenesis of the tumor is discussed.

Adult↗
PubMed1981

Patterns of mucin secretion in neoplastic and non-neoplastic diseases of the colon.

Changes in the pattern of sulfomucin and sialomucin secretion and height of large bowel mucosa have been described adjacent to primary colonic adenocarcinomas and adenomas, and called "transitional" mucosa. These changes were initially thought to be specific preneoplastic changes. In this study "transitional" changes in colonic and rectal mucosa were found in some cases overlying benign mesenchymal tumors, metastatic tumors from noncolonic sites, and sites of endometriosis, as well as adjacent to primary colonic and rectal neoplasms. These findings suggest that although these changes may be found adjacent to primary large bowel neoplasms, they are frequently secondary reactive rather than primary preneoplastic phenomena. In addition, the thickness of the mucosa and the accompanying pattern of mucin secretion usually seen in transitional mucosa may be dissociated.

Adenocarcinoma, Mucinous↗
PubMed1981

The histologic appearance of dysplasia (precarcinomatous change) in Crohn's disease of the small and large intestine.

Six patients with Crohn's disease and intestinal carcinoma are presented who demonstrated dysplastic changes in their intestinal mucosa. These changes were present adjacent to and/or distant from the infiltrating carcinoma and were extensive in 2 of these patients. The dysplasia affected many different cell types and was in many ways similar to that seen in ulcerative colitis. In view of the difficulties in making a clinical diagnosis of carcinoma in Crohn's disease, the finding of these changes on biopsy should be a strong indication for resection. However, as many of the carcinomas in Crohn's disease occur in excluded loops and in the small intestine, these changes will be of less value clinically than in ulcerative colitis, because access to these areas is difficult.

Adenocarcinoma↗
PubMed1981

Dysplasia-associated lesion or mass (DALM) detected by colonoscopy in long-standing ulcerative colitis: an indication for colectomy.

In performing colonoscopy over a 4-yr period on 112 patients with long-standing ulcerative colitis, a dysplasia-associated lesion or mass (DALM) was found in 12. This appeared as either a single polypoid mass (5 cases), a plaquelike lesion (2 cases), or multiple polyps (5 cases). In 7 of these 12 cases carcinoma was subsequently found. This was particularly true in the 5 cases of single polypoid masses where all 5 contained invasive carcinoma. In none of the cases associated with malignancy did multiple biopsies of the DALM reveal invasive carcinoma. In only 2 of the 7 patients with carcinoma was the dysplasia "severe," being "mild" or "moderate" in the remaining 5. In the 27 patients with dysplasia found incidentally in random biopsies of flat mucosa only one carcinoma was found, in contrast to the 7 cancers in 12 patients with DALM. This difference leads us to regard the finding of DALM, especially a single polypoid mass, as highly significant in patients with long-standing ulcerative colitis. It carries a sufficiently high risk of cancer, thereby constituting a strong indication for colectomy.

Adult↗
PubMed1980

Colitis of Behçet's syndrome--radiologic and pathologic features.

Three patients with Behçet's syndrome and colitis are described. The radiologic and histologic appearances of the colitis are discussed. The similarities of Behçet's colitis to Crohn's disease are outlined. The cases demonstrate the necessity to consider Behçet's syndrome in the differential diagnosis of inflammatory bowel disease.

Adult↗
PubMed1980

Crohn's disease and adenocarcinoma of the bowel.

We present six cases of cancer associated with Crohn's disease and stress the importance of the earlier age of onset than spontaneously arising small-bowel carcinoma, the long period of latency from the time of diagnosis of Crohn's disease to that of carcinoma, and the generally poor prognosis. We emphasize, furthermore, the frequent association with fistulas and the predisposition of bypassed or excluded segments of bowel to undergo malignant transformation. The occurrence of carcinoma in an excluded rectal stump has not previously been reported and stresses the necessity of resecting, rather than excluding, segments of bowel involved with Crohn's disease. These tumors are often not readily apparent by radiographic or endoscopic examination and in fact, may be discovered only after microscopic examination of resected or biopsied tissue.

Adenocarcinoma↗
PubMed1980

Solitary rectal ulcer syndrome: radiologic manifestations.

The solitary rectal ulcer syndrome is a distinct clinical entity occurring mainly in young patients who experience rectal bleeding. Solitary, and occasionally multiple, ulcers occur predominantly on the anterior or anterolateral aspects of the rectum. Current theories attribute this to pelvic muscle discoordination during defecation with partial rectal mucosal prolapse and traumatic ulceration. Classical histologic changes have been demonstrated that enable accurate diagnosis by the pathologist. Ten cases of biopsy-proven solitary rectal ulcer syndrome were reviewed. The radiographic abnormalities were: nodularity of the rectal mucosa (three cases), stricture formation (two cases), polypoid rectal masses (two cases), and ulceration (two cases). Radiologically this condition must be differentiated from other more serious entities such as carcinoma or inflammatory bowel disease.

Adolescent↗
PubMed1980

Double minutes in human large bowel cancer.

Two patients with large bowel carcinoma are described in whose tumors the presence of double minutes was observed. In one of these, the first such patient to be reported, double minutes were present in 100% of metaphases examined in both the primary tumor and its liver metastasis. The number of double minutes varied from 6 to 93 per metaphase. In the second patient, double minutes were seen only in two metaphases. The literature on double minutes is summarized, and it is concluded that double minutes are found in a wide spectrum of tumors, including human large bowel cancer and are not confined to tumors of neurogenic origin as suggested by earlier workers. In additon, evidence is suggestive of an association between the lack of differentiation and the presence of double minutes, but further data are required to substantiate this.

Adenocarcinoma↗
PubMed1979

Chromosome analysis of primary large bowel tumors: a new method for improving the yield of analyzable metaphases.

Colon tumors were processed immediately after surgical resection. Using L-Arterenol and sodium citrate in combination with standard chromosome culture techniques, 12 of 17 consecutive tumors (75%) had countable figures ranging from 5 cells to 59 cells. Seven of the 12 cases had over 25 countable cells. Chromosome counts did not vary more than +/- 4 for any one case. Seven tumors were karyotyped, 6 with banding techniques. One of these specimens had mosaic patterns. The chromosome counts varied: 2 were hypodiploid; 1 was pseudodiploid and 4 were hyperdyploid. There were some similarities in the karotypes although no identical karyotypes were seen in this series.

Adenocarcinoma↗
PubMed1979

Nonalcoholic liver disease. Overlooked causes of liver injury in patients with heavy alcohol consumption.

Alcoholic subjects with abnormal liver chemistry studies are often assumed to have alcoholic liver disease, even though the diagnosis is not established by liver biopsy. To determine the magnitude of nonalcoholic liver disease in patients with heavy alcohol consumption, the data on 145 consecutive patients judged to consume at least 80 g of alcohol daily for prolonged periods, and who underwent liver biopsy at the University of Chicago, were reviewed. Nonalcoholic liver disease was suspected clinically and confirmed by liver biopsy in 40 (28 per cent), whereas alcoholic liver disease was suspected in 105 but confirmed in only 83 (80 per cent). The remaining 22 patients had liver disorders, including cholangitis or pericholangitis, acute hepatitis or some form of chronic hepatitis, for which they required appropriate therapy. Neither clinical features, hepatitis B surface antigen (HBsAg), anti-HBsAg nor serum glutamic oxaloacetic transaminase to serum glutamic pyruvic transaminase (SGOT:SGPT) ratios distinguished these 22 patients from those with alcoholic liver disease. Thus, liver biopsy is necessary for the identification of nonalcoholic liver disease in patients suspected of harboring alcoholic liver disease, since other clinical features do not allow identification of these patients.

Acute Disease↗