A VITAMIN D3-DEPENDENT FACTOR INFLUENCING CALCIUM BINDING BY HOMOGENATES OF CHICK INTESTINAL MUCOSA.
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Biomedical subjects
Publications and source records attributed to R H WASSERMAN.
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A utoradiographs of kidney sections from rats injected with sodium 22 showed two areas of relatively high concentration of the radioisotope. The first area appeared in the outer medulla; the second appeared as an area of increasing concentration toward the papilla. Autoradiographs of sections labeled with chloride-36 appeared essentially the same. Autoradiographs of sections labeled with inulin-C(14)OOH showed an increased concentration in the inner medulla. These results may have a bearing on the counter-current multiplier hypothesis for the production of concentrated urine.
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In studies of the living rat, it was observed that ionic calcium is transferred against a concentration gradient and an electropotential gradient by the duodenal membrane; this would constitute evidence for the active transport of calcium in intestinal absorption and corroborates earlier observations made in vitro. The significance of this process in regard to total calcium absorption is unknown at present.
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