PubMed Health⌕ Search

Biomedical subjects

R H Waring

Publications and source records attributed to R H Waring.

At least 127 records · Page 7Linked to original sources
PubMed1981

The disposition and metabolism of 3,4',5-tribromosalicylanilide and 4'5-dibromosalicylanilide in the rat.

1. The metabolism of two pesticides, 3,4',5-tribromosalicylanilide (TBS) and 4',5-dibromosalicylanilide (DBS) has been studied after oral administration to rats. 2. Approximately 65% of the dose of TBS is absorbed, and then excreted as glucuronide and sulphate conjugates of two hydroxylated metabolites. One of these has been identified as 4'-hydroxy-3,5-dibromosalicylanilide, while evidence suggests that the other metabolite is 5-hydroxy-3,4'-dibromosalicylanilide. 3. In contrast, only 11% of the dose of DBS is absorbed; it is then excreted mainly as glucuronide and sulphate conjugates of the parent molecule.

Animals↗
PubMed1981

The metabolism and disposition of 3,5-dibromosalicylanilide in male and female rats.

1. The metabolism of the pesticide, 3,5-dibromosalicylanilide, has been studied following oral administration to rats. 2. This compound is more toxic than other brominated salicylanilides, some fatalities being recorded at an oral dose of 100 mg/kg. 3. 3,5-Dibromosalicylanilide is well absorbed, and excreted in urine and bile as sulphate and glucuronide conjugates of the parent compound and of several phenolic metabolites. Radioactivity was present in tissues (blood, kidney, liver, fat) six days after dosing with 3,5-dibromosalicyl[14C]anilide. 4. Sex-differences occur, both in excretion route and in the proportions of urinary metabolites.

Animals↗
PubMed1980

Variation in human metabolism of S-carboxymethylcysteine.

The metabolism of an oral dose of S-carboxymethylcysteine (SCMC) has been studied in man; the principal urinary component after 24 h was the unchanged compound (29.4-83.7%, 20 subjects). Markers variation was found between individuals; SCMC sulphoxide, S-methylcysteine, N-acetyl-S-carboxymethylcysteine, N-acetyl-S-methylcysteine with the corresponding sulphoxides and dicarboxymethylsulphide were also found as metabolites.

Biotransformation↗
PubMed1978

The metabolism of S-carboxymethylcysteine in rodents, marmosets and humans.

1. The metabolism of S-carboxymethylcysteine (Mucodyne) has been studied in the rat, rabbit, guinea-pig, marmoset and human. All species studied, except the rabbit, excrete large amounts of the parent compound. 2. Rabbits and humans give S-carboxymethylcysteine sulphoxide, rats form N-acetyl-S-carboxymethylcysteine while marmosets excrete methylmercapturic acid as other major metabolites. Traces of methylmercapturic acid sulphoxide, methylcysteine, methylcysteine sulphoxide and 3-(S-carboxymethylthio)lactic acid were also found.

Adult↗
PubMed1978

An improved method for gas chromatographic determination of urinary xylitol and glucuronic, glucaric gulonic and ascorbic acids, with their values in the rat, rabbit, guinea-pig and marmoset.

1. Urinary levels of xylitol and glucuronic, glucaric, gulonic and ascorbic acids were measured in the rat, rabbit, guinea-pig and marmoset by an improved g.l.c. technique. 2. Administration of a compound (2-methylbenzanilide) known to be conjugated and excreted as a beta-glucuronide had some effect on the output of these compounds of the glucuronic acid pathway in all four species, and caused a significant decrease in gulonic acid in the rat.

Animals↗
PubMed1976

The metabolism of chlorpromazine in the neonatal guinea-pig.

The metabolism of chlorpromazine in the neonatal guinea-pig has been studied. Maximal urinary excretions of sulphoxide occurred at 5 and 14 days, maximum excretion of both conjugated phenols and glucuronides at about 10 and 18 days.

Age Factors↗
PubMed1976

Some phenolic metabolites of 2, 4-diaminotoluene in the rabbit, rat and guinea-pig.

1. After administration of 2,4-diaminotoluene to rabbits, rats and guinea-pigs, phenolic metabolites are excreted, the major component being 5-hydroxy-2,4-diaminotoluene in all species investigated. Acetylated aminophenols and glucuronide conjugates were also found. 2. Rabbits, which produced the largest amounts of free amino-phenols, also had the highest levels of methaemoglobin in vivo.

Animals↗