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Biomedical subjects

R Häcker

Publications and source records attributed to R Häcker.

31 records · Page 2Linked to original sources
PubMed1981

[Glycolysis during hypothermic storage preservation of the liver].

Porcine livers were preserved for 6 hours by simple hypothermic storage using plasma-protein-fraction, albumin, Collins C2, Ringer solution, and Ring-trickle-perfusion. Following glycolytic metabolites were examined: G6P, F6P, FDP, GAP, 2PG, PEP, pyruvate, and lactate. An alteration of glycolytic metabolite-profile by the different preservation methods was not seen. There is a limitation of glycolysis by the pyruvate-kinase-reaction. Glycolysis decreases depending from preservation time. An artificial increasing of glycogen or rate of glycolysis before hepatectomy seems to be without any effect.

Animals↗
PubMed1981

[Behavior of adenine nucleotides ATP, ADP and AMP in liver preservation].

Porcine livers were preserved by simple hypothermic storage using plasma-protein-fraction (PPF), albumin- (A), Collins C2- (C), Ringer-solution or Ringer trickle perfusion. Adenine nucleotides were examined. The highest ATP-concentration after 6 hours was achieved by PPF. The sum of adenine nucleotides differed only slightly in PPF-, A-, or C-preservation and was higher than after R- or RT-preservation. The terminal concentration solution is given. An artificial increasing in AdN-content before hepatectomy is probably without any effect.

Adenine Nucleotides↗
PubMed1979

[Arterial blood supply of the liver].

We examined (dogs) the influence of hypovolaemic shock and reversible interruption of the portal vein on the arterial blood flow and metabolism of the liver. Depending on the arterial mean-pressure hypovolaemic shock decreases the flowrate of the hepatic artery, while it is increases to 30 to 40% during interruption of the portal vein. Whether hypoxy will cause liver damage or not is only dependant from the resulting oxygen supply of the liver. This critical range is below 6 to 7 ml/min per 100 g liver tissue.

Animals↗
PubMedDate not supplied

Enhanced maze performance and reduced oxidative stress by combined extracts of zingiber officinale and ginkgo biloba in the aged rat.

Here we assessed the effects of i.g. administration of Zingicomb (ZC), a mixture of zingiber officinale and ginkgo biloba extracts, on learning and memory, and on indicators of oxidative stress in aged rats. Effects of ZC (1 and 10 mg/kg) were investigated in 22-24 months old Wistar rats using the Morris water maze, in which they show deficient performance as compared to 3 months old rats in the undrugged state (days 1 and 2). Treatment was administered on days 3 and 4 of training, then over 7 days with training discontinued, and again on days 5 and 6 when training was resumed. Thereafter chronic treatment was maintained over 5 months. 1 mg/kg ZC improved escape learning in the water maze. The two capital indicators of oxidative stress in brain homogenates, the amount of oxidized proteins (assessed as carbonyl group containing proteins) and lipid peroxidation, were significantly reduced in ZC treated animals. Thus, ZC, which had previously been shown to improve inhibitory avoidance learning and to have anxiolytic properties in adult animals, might also facilitate spatial learning in aged animals, and reduces indices of oxidative stress in brain tissue after chronic treatment.

Aging↗