PubMed Health⌕ Search

Biomedical subjects

R Häring

Publications and source records attributed to R Häring.

At least 55 records · Page 3Linked to original sources
PubMed1988

[Accomplishments of tumor surgery in tumors of the stomach].

Accomplishments of gastric cancer surgery include (1) reduced operative risk, (2) surgical strategy based on histology and location of the carcinoma, (3) more operative radicalness (gastrectomy with extended lymph node dissection), (4) prolonged survival time and (5) adjuvant therapy (cytostasis, immunological treatment, intraoperative radiotherapy). In 1,070 patients the resection rate changed from 56% to 75%, the lethality rate of gastrectomy fell from 28% to 1.1% while the rate of gastrectomy increased from 21% to 68%. The stage of the tumor of operation influences the five-year-survival rate. As an additional treatment intraoperative radiotherapy has been introduced at our clinic.

Anastomosis, Roux-en-Y↗
PubMed1988

[Cryosurgery of the healthy rat liver].

Cryosurgical treatment was applied to normal liver tissue of 13 clinically intact rats, with a view to investigating effects of freezing temperatures upon normal liver tissue. The animals were sacrificed after different intervals from surgery, and their liver tissue was macroscopically and histologically examined. Major postoperative complications were not observed but for one animal which died of wound healing disorder. The method seems to be suitable also for treatment of liver cell carcinoma or liver metastases.

Animals↗
PubMed1988

[Animal experiment studies of cryosurgical treatment of DS sarcomas and Morris hepatomas implanted in the liver].

Cryosurgical treatment was applied to solid liver tumours of rats with a view to studying the effects of freezing temperatures upon liver carcinoma. Such treatment was applied to twelve rats to which carcinomas, 0.5 cm to 3.0 cm in size, had been implanted. Cryosurgical treatment was successful in one case. Many of the animals died of complications which resulted from freezing of surrounding organs, such as stomach or greater liver vessels.

Animals↗
PubMed1988

[Regeneration of the liver under the influence of E. coli endotoxin].

Studies were conducted into regeneration of rat liver exposed to the action of E. coli endotoxin, following two-third resection. No accelerated regeneration was found to take place in the wake of two-third hepatectomy and following postoperative intraperitoneal administration of E. coli endotoxin. However, regeneration was accelerated with significance in response to preoperative administration of 0.1 mg/kg body weight of E. coli endotoxin (B 5:55 DIFCO).

Animals↗
PubMed1988

[Endotoxinemia and bacteremia in manual oral decompression of ileus].

In the framework of the present clinical prospective study using a randomly selected patient collective, the question was pursued whether manual oral decompression (MOD), done in connection with surgical intervention in severely ill patients with ileus of the large and small intestine, leads to detectable bacteremia or higher concentrations of endotoxin in serum. From October, 1985 to March, 1987, bacteriological tests were conducted and the endotoxin concentrations in serum were measured in a total of 31 patients. 71% of the patients were female and 29% were male, aged 18-89. The endotoxin measurement was conducted with the aid of the limulus-amoebocyte-lysate (LAL) test, modified according to Piotrowicz. Additionally, bacteriological tests were done of the operation sites and the decompressed gastro-intestinal secretions. Simultaneously, cultures from the central blood stream were prepared. The tests showed that bacteremia and endotoxinemia occur in connection with manual oral decompression (MOD). Neither of the two, however, has any clinically relevant influence on the further post-operative course. Thus, manual oral decompression continues to represent an indispensable maneuver in the surgical management of an ileus.

Adolescent↗
PubMed1987

[Esophagitis--hiatal hernia--indications and choice of procedure: fundoplication].

The fundoplication, described by Nissen in 1956, is still an excellent and the most frequently applied antireflux operation in cases of refluxesophagitis. Accurate preoperative evaluation and subtile operative technique are imperative, however. Typical postoperative syndromes will be discussed. Details of the results will be given with particular regard to 214 fundoplications carried out on our own patients: mortality rate 0%, recurrence rate 4.7%, content with the result of the operation 88%.

Esophagitis, Peptic↗
PubMed1987

Perioperative antibiotic prophylaxis in bile-duct interventions: results of two prospective randomized studies.

The success of perioperative prophylaxis in gallbladder surgery was examined in two prospective randomized studies with a total of 326 patients. Postoperative wound-healing impairments did not occur in any of the patients receiving a single preoperative application of an antibiotic with a high biliary elimination rate (ceftriaxone or apalcillin). 11% of a control group without prophylactic antibiotic application evidenced infectious wound-healing disturbances.

Adolescent↗
PubMed1986

Low molecular weight heparin plus dihydroergotamine for prophylaxis of postoperative deep vein thrombosis.

In a prospective, double-blind investigation of the prophylaxis of deep vein thrombosis (DVT) in patients undergoing elective major abdominal surgery, 269 patients were randomized into two groups. One hundred and thirty-two patients received a fixed combination of heparin sodium 5000 units plus dihydroergotamine mesylate 0.5 mg (H/DHE) twice a day and 137 patients received a fixed combination of low molecular weight heparin 1500 units plus dihydroergotamine mesylate 0.5 mg (LMWH/DHE) once a day as well as one injection of placebo per day. Treatment was initiated 2 h pre-operatively in both groups and continued for 7-10 days. The frequency of DVT determined by the 125I-labelled fibrinogen uptake test and phlebography was 10.3 per cent in patients receiving H/DHE and 10.4 per cent in those receiving LMWH/DHE. DVT of the femoral vein was detected in four patients of the H/DHE group and in none of the LMWH/DHE group. Intra- and postoperative blood loss did not differ significantly between both groups. Also no difference in the development of wound haematoma and injection site haematoma was found. While intra-operative volume substitution was comparable in both groups, significantly more patients under H/DHE prophylaxis received volume substitution during the postoperative phase. These results show that once-daily prophylaxis with the combination of low molecular weight heparin and dihydroergotamine is equally as effective and as safe as the twice-daily regimen using a combination of unfractionated heparin and dihydroergotamine in patients undergoing elective, major abdominal surgery. The advantages of the once-daily regimen of LMWH/DHE include greater patient acceptance, less nursing time and greater cost effectiveness, provided the new combination can be sold at a cost which maintains this advantage.

Abdomen↗
PubMed1986

[Prevention of thromboembolism with heparin-DHE--safety and trends].

Perioperative thrombosis prophylaxis with low dose heparin-DHE. Efficiently protects against thromboembolic complications. Side effect such as haemorrhage or vasospasms are rarely seen. The known contraindications of DHE have been respected strictly. The latest development is low molecular heparin which has been tried out and evaluated on the ground of a controlled double blind study of 259 patients undergoing general surgery. The study shows the following advantages: thrombosis prophylaxis by one injection pro die only. This means less work for the staff and lower costs. Further studies on low molecular heparin are necessary.

Adult↗
PubMed1986

[Systemic antibiotic prophylaxis with metronidazole in elective colonic and rectal surgery. Results of a clinical controlled study and a critical literature review].

The pathogen spectrum of wound infections in colon surgery is composed almost exclusively of facultatively aerobic and obligatorily anaerobic intestinal flora. A study was performed in which a one-shot prophylaxis was carried out by applying metronidazole, 500 mg i.v., or latamoxef (lamoxactam) 2 g i.v., on induction of anesthesia. The metronidazole group evidenced a 26.3% incidence of infections due exclusively to aerobic pathogens. In the latamoxef (lamoxactam) group, it was possible to achieve a reduction of the postoperative rate of wound infections to 11.1%. The study was prematurely terminated because of the high rate of wound infections in the metronidazole group and the exclusive selecting of aerobic pathogens.

Colon↗