PubMed Health⌕ Search

Biomedical subjects

R Hambleton

Publications and source records attributed to R Hambleton.

At least 19 recordsLinked to original sources
PubMed1997

Anesthetic effects of tiletamine-zolazepam, alone or in combination with butorphanol, in goats.

OBJECTIVE: To evaluate anesthetic effects of tiletamine-zolazepam (TZ), alone or in combination with butorphanol, in goats undergoing laparotomy for embryo collection. DESIGN: Randomized clinical trial with crossover design. ANIMALS: 9 adult female goats. PROCEDURE: Goats were anesthetized twice: once with TZ (5.5 mg/kg [2.5 mg/lb] of body weight, i.v.) and once with tiletamine-zolazepam and butorphanol (0.1 mg/kg [0.045 mg/lb], i.v.). Additional doses of TZ (0.5 to 1.0 mg/kg [0.23 to 0.45 mg/lb], i.v.] were administered as needed to maintain a surgical anesthetic plane. Time to sternal recumbency was recorded, and quality of induction was scored. Arterial pressures, heart rate, respiratory rate, and rectal temperature were recorded every 5 minutes; arterial blood samples were collected every 30 minutes. Oxygen was insufflated if estimated saturation of hemoglobin in peripheral arterial blood with oxygen was < 90%; intermittent positive-pressure ventilation was performed if goats became apneic. Muscle relaxation, quality of anesthesia, and eye signs were scored every 15 minutes during anesthesia. Anesthesia time was recorded, and quality of recovery and degree of postoperative analgesia were scored. Plasma cortiso concentration was measured before induction, immediately after extubation, and 2 hours after extubation. RESULTS: Induction was rapid and smooth. Five goats regurgitated, 3 required supplemental oxygen, and 1 required intermittent positive-pressure ventilation, but none of the goats became hypotensive. Muscle relaxation and quality of anesthesia were adequate. Goats recovered from anesthesia without complications. We did not detect any significant differences between anesthetic regimens for any of the variables measured, except bicarbonate concentration and base excess. CLINICAL IMPLICATIONS: TZ at a dose of 5.5 mg/kg was satisfactory for anesthetic induction in goats; additional doses can be given to extend anesthesia time, but addition of butorphanol at a dose of 0.1 mg/kg to this regimen does not seem to provide any measurable benefit. An oxygen source and a means of assisting ventilation should be available.

Analgesics, Opioid↗
PubMed1988

An investigation into information provided for patients on home parenteral nutrition.

A group of 34 patients who received home parenteral nutrition (HPN) were assessed by questionnaire to determine their knowledge of basic nutritional concepts, parenteral nutrition and the procedures used to monitor HPN. The results indicated that the HPN patients had an adequate knowledge of basic nutritional concepts and that this knowledge was not significantly different from that of 76 randomly selected control subjects. However, the HPN patients had significantly less understanding of parenteral nutrition and the procedures used to monitor HPN. Based on information obtained, a booklet was written to explain HPN to the same group of patients. Eighty-eight per cent of patients found the booklet either interesting or very interesting and 91% of patients reported that the booklet was read by other family members as well as themselves. Patients who had been on HPN for short periods of time learnt more from the booklet than other patients. Many patients would have appreciated more information about HPN when they first began treatment.

Humans↗
PubMed1987

Monitoring devices.

Explore the source record for details and available documents.

Central Supply, Hospital↗
PubMed1985

Development and application of the student test used in the School Health Education Evaluation.

To accurately assess the health knowledge, attitudes, and practices of students in grades four-seven, the staff of the School Health Education Evaluation (SHEE) project devoted extensive effort to identify a test appropriate for such assessment. An extensive literature review failed to produce an instrument sufficiently comprehensive or psychometrically sound that could be employed. In this paper, the philosophic orientation and the detailed processes followed in developing a noncurriculum specific, psychometrically sound evaluation instrument for use in the study is described. Included are the bases for the test framework, test objective development, test item review, the various measures constructed using the test blueprint, student performance on the test battery, the psychometric qualities of the test, and suggestions for appropriate use of the final test in other school health education settings.

Attitude to Health↗
PubMed1983

T.S.T.--a new range of indicator devices for autoclaving processes.

Simple process indicators, usually relying on a colour change, are widely used as an aid to user assessment of the success or otherwise of autoclaving processes. Ideally, a process indicator should be capable of indicating not only that heating in steam has occurred but that heating has been maintained at a correct level for a suitable period of time. Furthermore, it would be preferable if any colour changes were abrupt rather than gradual throughout the period of heating.

Color↗
PubMed1981

Evaluation of a prototype micro-electronic autoclave cycle integrator.

Instability and non-uniformity of spore preparations and the non-conformity of chemical indicators to the temperature coefficients of spore inactivation are problems associated with current methods of autoclave cycle monitoring. A prototype micro-electronic instrument, which largely overcomes these problems, is described. It monitors autoclave cycles in terms of the integral F0 and Nabla functions. Its thermometric and integrating accuracy is demonstrated. A discussion of the problems associated with the use of sensitive electronic instruments in the autoclave room environment reveals the need for independent monitoring areas when such devices are used. Inactivation constants were determined for spores of the organism Bacillus stearothermophilus, NCTC 10 003 and were described using D115 (12.0 min) and Z (9.0 degrees C) values and the first order reaction Arrhenius constants A 10(41.2) min-1) and Ea (74.4 kcal mol-1, 311 kJ mol-1). These have been compared with recently published values. The standardization of F0 and Nabla is discussed with reference to the setting of minimum values related to product bioburden and maximum values related to an acceptable degree of product degradation.

Electronics↗
PubMed1977

Supply, need, and distribution of anesthesiologists and nurse anesthetists in the U.S., 1972 and 1980.

This paper examines the relationship between problems in anesthesia care delivery and the availability and utilization of trained anesthesia manpower. The 1972 and 1980 projected supply and mix of anesthesiologists and nurse anesthestists is described and compared to the current and projected need for their services. The need estimates developed for anesthesia manpower are based upon published data on operations, productivity and theoretical team configurations. Utilization data are used since they are quantifiable and the need for anesthesia services is, indeed, supply-induced. Two estimates of need are developed based upon differing degrees to which anesthesia teams can be effectively employed, this being contingent upon the size of the hospital operative workload. While the need estimates developed for anesthesiologists for 1972 and 1980 were fairly close in aggregate number to the actual and projected supply; the need estimates for nurse anesthetists fell far short of their 1972 and 1980 projected supply. The 1972 need estimates are then compared on a statewide basis to the actual supply and mix of anesthesia personnel to reveal a severe maldistribution which is quantified in terms of shortage and execesses of anesthesiologists and nurse anesthetists for each state.

Anesthesiology↗
PubMed1975

Pressure changes in bottles during sterilization by autoclaving.

A method is described to measure changes in pressure inside a bottle during autoclaving without disturbing the integrity of the seal. Experiments showed that, in a perfectly sealed bottle, the pressure rose to a maximum of 58.2 psi absolute. If the rubber linear was unable to maintain the seal, air leaked slowly from the bottle both during the heating-up and the early sterilization period.

Drug Packaging↗