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Biomedical subjects

R Hanke

Publications and source records attributed to R Hanke.

At least 37 records · Page 2Linked to original sources
PubMed1983

[Round atelectasis].

a) For several reasons Sinner's paper calls for critical remarks: His term "Pleuroma" for a neither pleural nor tumorous but intrapulmonary and atelectatic mass lesion lacks any anatomical and histological basis and is misleading at that because it pretends a tumor of the pleura; his statement in the summary that atelectatic pseudotumors of the lung show a tumorcell-like cytoarchitecture is surprising without being further discussed by the author; he encourages risky invasive diagnostical procedures even in cases where the radiological diagnosis of round atelectasis is unmistakable; already known radiologic features of round atelectases are presented by him as hitherto undescribed; his conceptions of the formal development of round atelectases and of their most characteristic features can not be agreed with. b) The different forms of round atelectases and their residuals are presented with tomograms and with diagrams of their formal development from our point of view.

Bronchiectasis↗
PubMed1979

Pre-mRNA from erythroid enriched bone marrow cells of the rabbit.

Different fractions of cellular RNA from erythroid enriched bone marrow cells of the rabbit, extracted by the temperature fractionation method, were investigated by hybridization to globin cDNA. 97.4% of all globin sequences were found in the 4 degrees C franction (cytoplasmic RNA) 0.11% are in the 40 degrees / 50 degrees C fraction and 2.47% in the 65 degrees C and 85 degrees C franctions (pre-mRNA). This shows a substantial purification of the pre-mRNA fractions from cytoplasmic mRNA. 33% of the globin sequences in the 65 degrees C and 85 degrees C fractions are polyadenylated. The poly(A)+-RNA from the 65 degrees C and 85 degrees C fractions separated in a formamide sucrose gradient showed a clear hybridization to globin cDNA in the region between 9S and 28S and around 4S. In a control experiment in which RNA from baby hamster kidney cells (BHK) was mixed with globin mRNA and separated in the same manner hybridization was observed at the 9S position of the gradient only.

Animals↗
PubMed1978

[The pulmonary ligament (pulmo-diaphragmatic ligament) (author's transl)].

The paper considers the appearances of the contour of the diaphragm and of the normal irregularities of the diaphragm. The hitherto existing opinion of ill defined or tented diaphragmatic outlines always being the result of pleurodiaphragmatic implications in inflammatory or fibrotic processes in the basis of the lung needs to be corrected: In a great number of p.a. chest roentgenograms of healthy persons a more or less obvious ill definition or tenting of the medial part of the diaphragma can be found, caused by a variation of the pulmonary ligament characterized by its connection with the diaphragmatic pleura. Ill definition and tenting of the diaphragmatic outline caused by this variation of the pulmonary ligament are called physiological alterations, contrary to similar pathological (e.g. adhesive) ones. Only if this anatomical variation exists a pulmonary ligament can be roentgenologically visualized directly.

Diaphragm↗
PubMed1977

[Gliadin-induced migration inhibition of peripheral leucocytes by the agarose-plate technique in patients with coeliac disease (author's transl)].

Sensitisation to gliadin was studied--using a modified leucocyte-migration inhibtion test after Clausen--in patients with coeliac disease (10 patients), ulcerative colitis (9), terminal ileitis (9), bacterial diarrhoea (9), and other gastro-intestinal diseases (14). Only the group of patients with coeliac disease had such specific sensitisation. The migration index, at 0.72 +/- 0.06, was significantly lower in them than in other groups. This reaction is disease-specific and indicates that in coeliac disease cellular immune mechanisms also play a role. The specificity of the reaction can also be used diagnostically.

Celiac Disease↗
PubMed1976

[The leucocyte-migration-inhibition-test in the diagnostic of sarcoidosis (author's transl)].

The positive diagnosis of a sarcoidosis is often difficult since reliable laboratory and radiological parameters are not available. It is therefore often necessary to make the diagnosis with invasive methods. The Kveim skin test has many disadvantages, so that there have been many trials to facilitate the diagnosis by in vitro systems. With a modified and easy handable leucocyte migration technique in agarose (Clausen technique), 30 patients with certified sarcoidosis were tested. As controls served healthy volunteers and patients with various diseases such as Hodkins disease, Crohn's disease, tuberculosis etc. As antigene a Kveim suspension typ I was prepared according to Chase and was used in a concentration of 100 mug/ml. It could be shown, that leucocytes from patients with sarcoidosis demonstrated a significant inhibition of their migration in presence of Kveim antigene. Besides patients with Crohn's disease in no other group there was a migration inhibition. Therefore this in vitro system allows diagnostic differentiation and helps to find the diagnose which compares well to the results obtained with the Kveim skin test. Since the test is easy to perform and the results are available after 24 h the test is of diagnostic value for the clinical routine.

Cell Migration Inhibition↗