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Biomedical subjects

R Hanno

Publications and source records attributed to R Hanno.

At least 19 recordsLinked to original sources
PubMed1988

Cutaneous mast cell quantity in pruritic and nonpruritic hemodialysis patients.

Pruritus remains a significant complication of end-stage renal disease. Its cause in hemodialysis patients is not known. It has been postulated that increased numbers of mast cells occur in these patients and may account for the presence of pruritus. Our objective was to determine if there is a difference in the number of cutaneous mast cells between pruritic and nonpruritic patients. A 3-mm punch biopsy specimen was obtained from pruritic (n = 7) and nonpruritic (n = 6) hemodialysis patients. We observed no significant difference in the quantity of cutaneous mast cells in pruritic and nonpruritic hemodialysis patients. We conclude that the etiology of pruritus in hemodialysis patients is not related to an increase in the number of cutaneous mast cells.

Aged↗
PubMed1987

Tuberous sclerosis.

Tuberous sclerosis is a multisystem disorder characterized by changes primarily involving the skin, eye, and central nervous system. Although the disease often produces mental retardation and seizures, this is not universal, and some patients with tuberous sclerosis lead a relatively normal life.

Diagnosis, Differential↗
PubMed1987

Pruritus ani. Classification and management.

Pruritus ani is a common dermatologic complaint that can be frustrating to treat. Effective therapy depends upon recognition of a variety of etiologic factors that may contribute to the symptom.

Humans↗
PubMed1986

Longitudinal nail biopsy in evaluation of acquired nail dystrophies.

We reviewed longitudinal nail biopsies performed at Henry Ford Hospital on patients with acquired nail dystrophies to see whether the procedure did, indeed, provide useful diagnostic information and to see which microscopic features were most helpful in histopathologic diagnosis. Clinical diagnoses included psoriasis, lichen planus, Darier's disease, isolated longitudinal defects, and diffuse thickening. We found that clinical diagnosis could be supported by histopathologic findings in eight of twenty cases of acquired nail dystrophy. Specifically, we were able to make a diagnosis of psoriasis in four cases, lichen planus in three cases, and Darier's disease in one case. The other twelve cases showed nonspecific eczematous changes. We conclude that the longitudinal nail biopsy may be a useful diagnostic tool in certain cases of acquired nail dystrophy.

Biopsy↗
PubMed1985

Cutaneous B cell lymphoma: diagnostic use of monoclonal antibodies.

A patient presented with a solitary plaque initially interpreted on light microscopy as benign lymphoplasia. Monoclonal antibody studies were used to define the B cell origin of the infiltrate and to characterize its probable malignant potential. Monoclonal antibody typing is a useful technique to evaluate lymphocytic infiltrates that may be difficult to categorize on the basis of routine light microscopy.

Antibodies, Monoclonal↗
PubMed1985

The phakomatoses.

Explore the source record for details and available documents.

Angiomatosis↗
PubMed1985

Histopathology of Gottron's papules.

We studied Gottron's papules in 11 cases of known dermatomyositis to determine whether the findings were similar to those in the poikilodermatous eruption usually biopsied in this disease. As in typical poikilodermatous dermatomyositis, basal layer vaculopathy, PAS-positive basement membrane thickening, upper dermal mucin deposition and a mild diffuse upper dermal mononuclear infiltrate were frequent findings. In contrast to poikilodermatous dermatomyositis, however, epidermal hyperplasia consisting of acanthosis or papillomatosis was often present and epidermal atrophy was rare. We conclude that a specific diagnosis of dermatomyositis can often be made on biopsy of a Gottron's papule.

Adolescent↗
PubMed1984

Cutaneous lesions of dermatomyositis are improved by hydroxychloroquine.

Dermatomyositis (DM) is a collagen vascular disease with prominent cutaneous findings. Although the myositis often responds to therapy with corticosteroids and/or immunosuppressives, the cutaneous disease may not respond. Seven patients with cutaneous lesions of DM that had not responded to therapy were treated with hydroxychloroquine in an open study. Three patients had idiopathic DM, one had DM without myositis, one had DM with malignancy, and one had adolescent DM. The response to the addition of hydroxychloroquine was good in all of the patients, and three had total resolution of their skin lesions. In two patients the corticosteroid dosage could be tapered. Therapy with hydroxychloroquine did not appear to have any beneficial effect on the myositis. We conclude that hydroxychloroquine may have a role as an adjuvant to the therapy of patients with cutaneous lesions of DM.

Adenocarcinoma↗
PubMed1982

Serum angiotensin I-converting enzyme level in patients with cutaneous sarcoidal granulomas.

In a previous study we found that only half of those patients presenting with cutaneous sarcoidal granulomas have evidence of systemic involvement. The current study was designed to determine whether abnormal angiotensin-converting enzyme (ACE) levels were predictive of multisystem disease. Serum ACE levels were determined in 15 patients with active cutaneous sarcoidal granulomas. The ACE levels were elevated in ten of the patients but did clearly differentiate those with systemic involvement. Three of the six patients with disease localized to the skin had elevated ACE levels, whereas seven of the nine patients with systemic disease had elevated ACE levels. The ACE levels did not correlate with the extent of cutaneous disease, or any individual or combined system involvement. A normal ACE level cannot be used to rule out a diagnosis of sarcoidosis and, conversely, an abnormal level does not confirm multisystem involvement.

Adult↗
PubMed1981

Pruritic urticarial papules and plaques of pregnancy (PUPPP). A clinicopathologic study.

Pruritic urticarial papules and plaques of pregnancy (PUPPP) was recently defined as an intensely pruritic cutaneous eruption occurring in the third trimester. We are reporting fifteen additional cases of this distinctive eruption. The lesions began in the third trimester in all but two patients. The rash consisted of a symmetric eruption of papules, urticarial lesions, and some erythema multiforme-like target lesions. Histologic examination showed a mild nonspecific lymphohistiocytic perivasculitis. Moderate or intense pruritus was present in all but one case. The abdomen and proximal extremities were most commonly involved, but two patients had lesions only on the lower legs. Clearing occurred prior to delivery (five cases), within 1 week of delivery (nine cases), and at 6 weeks postpartum (one case). The pruritus was decreased with topical corticosteroids and diphenhydramine in all cases except one. Fetal wastage did not occur. Subsequent pregnancies were uneventful in two patients. PUPPP is a benign dermatosis of pregnancy which resolves spontaneously or with delivery.

Adult↗
PubMed1981

Cutaneous sarcoidal granulomas and the development of systemic sarcoidosis.

Studies of patients with systemic sarcoidosis have indicated that those patients with cutaneous lesions have a poorer prognosis with a greater incidence of symptomatic pulmonary and ocular sarcoidosis. We examined 18 patients who had biopsy-proved cutaneous sarcoidosis for evidence of systemic involvement. Of the 13 patients who had no history of previously documented sarcoidosis, six had no evidence of systemic disease on history and physical examination, chest roentgenogram, pulmonary function testing, ocular examination, skin testing, and baseline laboratory testing. The seven remaining patients had evidence of sarcoidosis in another organ system, but six of the seven were essentially asymptomatic and required no therapy. The poorer prognosis associated with cutaneous sarcoidal granulomas drawn from populations with proved systemic sarcoidosis does not seem to apply to generally healthy outpatients with skin lesions as the initial manifestation of their disease.

Adult↗
PubMed1980

Brunsting-Perry cicatricial pemphigoid associated with bullous pemphigoid.

Brunsting-Perry cicatricial pemphigoid is a chronic recurrent vesiculobullous eruption that occurs predominantly on the head and neck. Because of the clinical, histologic, and immunologic similarity to cicatricial pemphigoid, it has been suggested that Brunsting-Perry cicatricial pemphigoid represents the cutaneous counterpart of cicatricial pemphigoid and should be included as a member of the pemphigoid spectrum of diseases. The concurrence of Brunsting-Perry cicatricial pemphigoid and bullous pemphigoid, as seen in the patient in this report, supports this viewpoint.

Adult↗
PubMed1980

Hodgkin's disease with specific bullous lesions.

A variety of bullous eruptions have been reported in patients with Hodgkin's disease, among them erythema multiforme, herpesvirus infections, bullous impetigo, prurigo-like papules with vesicles, drug eruptions, bullous pemphigoid, dermatitis herpetiformis, and acquired epidermolysis bullosa. We now describe a patient whose bullous eruption was thought initially to be bullous pemphigoid. However, histopathologic examination of a bulla showed a lymphomatous infiltrate beneath an intraepidermal and subepidermal blister. These pathological findings seem to be unique and we interpret them to be those of bullous Hodgkin's disease.

Diagnosis, Differential↗