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Biomedical subjects

R Harf

Publications and source records attributed to R Harf.

33 records · Page 2Linked to original sources
PubMed1987

[Therapeutic modalities applied to tuberculotics in the Rhône Department in 1982].

Four hundred tuberculous patients who had been recorded in the register of the Rhône department during 1982 were retrospectively investigated for treatment procedures (hospital care and drug regimen); 89 had to be excluded: 42 died during treatment, in 30 the initial diagnosis was no longer maintained, 17 were lost to follow up. Hospital admission was required in more than 91% patients and 60% patients were sent to sanatoria. The duration of hospital care varied with the physician (university or not, pneumologist or not), the disease (localization, bacteriology) and the patients: the shortest duration was seen in young North African women, the longest in maghrebian men. Compared with "official recommendation" chemotherapy is usually prescribed for longer than necessary (mean treatment duration: 11 months. Ethambutol prescription for 8 months). These data illustrate the usual gap seen between "scientific" data given by controlled trials and routine practice.

Adolescent↗
PubMed1985

[Pulmonary sarcoidosis. Study of the distribution of active alveolitis assessed by comparison of data from radiological examination, gallium 67 scintigraphy and double bronchoalveolar lavage].

Abnormal uptake of gallium in alveolar structures, raised lymphocyte levels, ECA and, to a lesser degree, proteins in alveolar washings are the principal currently known criteria used to recognise cases of sarcoidosis with persistent immunological activity. The contribution of data concerning broncho-alveolar washings (BAW) in the context of this diagnostic assessment has never been the subject of a critical evaluation. It would nevertheless seem that the distribution of sarcoidosis lesions is not always diffuse and homogeneous, leading to the possibility of errors of assessment in this technique. The aim of the present study was to assess the true existence, degree and consequences of this risk. It was based upon the study of 41 cases of active pulmonary sarcoidosis. Search for homogeneity and heterogeneity between lesions and active alveolitis involved precise radiological study, gallium isotope scan with determination of the index of uptake as well as the quality of the latter, and double BAW carried out in the most radioactive and least radioactive regions respectively. Comparative study of the results obtained showed that zones of active alveolitis were distributed unevenly and heterogeneously in more than half of the patients (71% for gallium and 54% for BAW). This would explain the fact that in 14 cases (34%) criteria of alveolar activity were present in only one of the two specimens of washings. Identification of the zones which should be included in BAW cannot be determined accurately by radiological analysis, regardless of the degree and distribution of radiological abnormalities.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1985

[Bronchoalveolar lavage data in localized pulmonary tuberculosis].

Twenty-two patients with radiologically localised pulmonary tuberculosis underwent one or more broncho-alveolar lavages: 10 patients had a single lavage in the disease area, 11 had two lavages (1 in a healthy zone and 1 in the affected zone) and 1 patient had a triple lavage. The laboratory analysis of the fluid revealed that the tuberculosis was accompanied by an elevation of the various proteins assayed and by an alteration in the cytology (lymphocytosis, neutrophilia or mixed) in the radiologically involved zone. In contrast,the healthy zone revealed normal values except in 2 cases which presented a lymphocytosis. The type of cytological abnormality does not appear to have any prognostic value, but is probably related to different pathophysiological mechanisms.

Adult↗
PubMed1982

Determination of rifampicin, desacetylrifampicin, isoniazid and acetylisoniazid by high-performance liquid chromatography: application to human serum extracts, polymorphonucleocytes and alveolar macrophages.

A method for the determination of rifampicin, desacetylrifampicin, isoniazid, and acetylisoniazid by high-performance liquid chromatography and using the same extract of the same sample is reported. After protein precipitation and extraction of these antituberculous drugs, two reversed-phase chromatographies were necessary. The technique was applied to serum extracts, polymorphonucleocytes and alveolar macrophages from patients treated for tuberculosis.

Chromatography, High Pressure Liquid↗
PubMed1981

Angiotensin converting enzyme in bronchoalveolar lavage fluid in pulmonary sarcoidosis.

Alveolar angiotensin converting enzyme (ACE) and serum ACE were measured simultaneously in 16 patients with histologically confirmed sarcoidosis and in 16 control subjects. Although alveolar ACE was abnormally elevated in all 15 cases of active sarcoidosis, serum ACE was not. No correlations were found between radiographic staging of pulmonary sarcoidosis and the levels of these enzymes. There was a clear correlation, however, between the levels of alveolar ACE and counts made on bronchoalveolar lavage fluid. This correlation was closer than that existing between serum ACE and bronchoalveolar lavaged lymphocytes. It is suggested that alveolar ACE is an additional biological marker of pulmonary sarcoidosis which is possibly more sensitive than serum ACE.

Adult↗
PubMed1980

[A thoracic "stealing" vascular syndrome (author's transl)].

The authors report quite a remarkable observation of a thoracic "stealing" vascular syndrome, apparently a sequela of a previous pleural involvement. It was a patient with fainting fits in effort related to severe hemo-diversion of the sub-pleural vascular laci fed by several vascular pedicles coming from the internal mammary artery and several broncho-intercostal arterial vessels. Selective bronchial arteriography revealed these pedicles, enabling an important blood derivation in effort without corresponding venous return, with a phenomenon of low cerebral outflow; a series of embolisms in these pedicles enabled to obtain a valuable obliteration of the main ones with a complete disappearance of the clinical signs. The syndrome mentioned in this observation is related to the "stealing" vascular ones described in the level of the subclavian artery.

Brain Ischemia↗
PubMed1980

[Is there a pleural involvement in bird-breeder alveolitis? (author's transl)].

The authors report the observation of a bird-breeder lung in which the first sign was a pleural involvement, as the serosa biopsy revealed lymphoplasmocytic inflammatory infiltrates, lesions compatible with this interpretation. No such observation was found in the literature. The true incidence of these eventual pleural involvements during these allergic diseases remains to be evaluated as well as their etiopathogenic determinism.

Adult↗