PubMed Health⌕ Search

Biomedical subjects

R Harries

Publications and source records attributed to R Harries.

6 recordsLinked to original sources
PubMed2003

Extrarenal retroperitoneal angiomyolipoma: management of a rare benign tumour.

BACKGROUND: Extrarenal retroperitoneal angiomyolipomas are benign tumours of mesenchymal tissue origin. The diagnosis of these tumours is usually based on the perioperative findings and confirmed by the resultant specimen's histology. The main differential diagnosis is liposarcoma, and accurate preoperative imaging combined with fine-needle aspiration cytology may permit a non-operative approach to these tumours. CASE PRESENTATION: We describe a single case of extrarenal retroperitoneal pelvic angiomyolipoma and provide the first case of magnetic resonance imaging of these extremely rare tumours. CONCLUSION: This article discusses the presentation, management, and outcome associated with these tumours.

Angiomyolipoma↗
PubMed2000

Galactorrhoea and hyperprolactinaemia associated with protease-inhibitors.

We describe four patients with galactorrhoea as an isolated endocrine abnormality after use of protease inhibitors (PIs) as part of both highly active antiretroviral therapy (HAART) and postexposure prophylaxis (PEP). This reaction may be a direct effect of PIs or may be indirectly mediated by the effect of PIs on the cytochrome P450 system, thus potentiating the dopamine antagonist effects of other drugs.

Anti-HIV Agents↗
PubMed1990

Clinical features and natural history of von Hippel-Lindau disease.

The clinical features, age at onset and survival of 152 patients with von Hippel-Lindau disease were studied. Mean age at onset was 26.3 years and 97 per cent of patients had presented by aged 60 years. Retinal angioma was the first manifestation in 65 patients (43 per cent), followed by cerebellar haemangioblastoma (n = 60, 39 per cent) and renal cell carcinoma (n = 15, 10 per cent). Overall, 89 patients (59 per cent) developed a cerebellar haemangioblastoma, 89 (59 per cent) a retinal angioma, 43 (28 per cent) renal cell carcinoma, 20 (13 per cent) spinal haemangioblastoma and 11 (7 per cent) a phaeochromocytoma. Renal, pancreatic and epididymal cysts were frequent findings but their exact incidence was not accurately assessed. Mean age at diagnosis of renal cell carcinoma (44.0 +/- 10.9 years) was significantly older than that for cerebellar haemangioblastoma (29.0 +/- 10.0 years) and retinal angioma (25.4 +/- 12.7 years). The probability of a patient with von Hippel-Lindan disease developing a cerebellar haemangioblastoma, retinal angioma or renal cell carcinoma by age 60 years was 0.84, 0.7 and 0.69, respectively. A comprehensive screening protocol for affected patients and at-risk relatives is presented, based on detailed analysis of age at onset data for each of the major complications. Median actuarial survival was 49 years, with renal cell carcinoma the leading cause of death.

Adrenal Gland Neoplasms↗
PubMed1986

Low molecular weight IgM. Detection using immunoblotting.

Two techniques for the definitive identification of low molecular weight (LMW) IgM have been compared, namely, filtration chromatography combined with nephelometry and a modified immunoblotting assay. The results indicate that the latter is a more sensitive and reliable technique. Furthermore the resolution of immunoblotting is such that it can distinguish additional oligomeric forms of IgM as well as monomeric IgM suggesting a disorder of polymerization of pentameric IgM. As the presence of LMW IgM in the sera of patients with various disorders is of prognostic significance the immunoblot technique merits consideration as a useful screening assay to detect this moiety.

Arthritis, Rheumatoid↗
PubMed1984

Face touching in monkeys, apes and man evolutionary origins and cerebral asymmetry.

The evolution of face touching, i.e. the use of the hand to touch the individual's own face, was studied in monkeys, apes and man with the object of examining which hand is used and which part of the face is touched. Monkeys show little if any face touching. Gorillas, orang- utans and chimpanzees show face-touching comparable to man. Left-hand face touching was superior to right-hand touching for both apes and humans. One feature which distinguished humans from other apes was the frequency of chin touching, which is generally high for man. It has been suggested that emotions are expressed more intensely on the left side of the face and it was thought that the left hand is used by the right hemisphere as a special pointer to heighten the effect of this.

Animals↗