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Biomedical subjects

R Heidrich

Publications and source records attributed to R Heidrich.

At least 19 recordsLinked to original sources
PubMed2001

[Megabacteria-associated proventriculitis in poultry in the state of Brandenburg, Germany].

During the second half of the year 2000, we have diagnosed a megabacterial-associated proventriculitis in 13 laying hens and 4 cocks from 14 different flocks and one turkey. All birds were submitted for necropsy because of progressive runting, increased mortality and poor laying performance in the herds. Routine diagnostic workup included necropsy, histology, bacteriology, parasitology and virology. At necropsy, the proventricular of the birds were enlarged. The walls were thickened and the mucosa covered with cloudy, grey-white mucus. Petechial haemorrhages and ulcerations predominantly at the proventricular-ventricular junction and sloughing of the necrotic koilin layer of the ventriculus were inconsistently present. Megabacteria (approximately 40-50 by 2-4 microns, gram-positive to gram-labile, rod-shaped organisms) were present in large numbers in touch preparations of the proventricular mucosal surface. In some of the preparations, the megabacteria showed a branching pattern similar to fungal hyphae. By histopathology, all birds showed moderate to marked, diffuse lympho-plasmacytic proventriculitis. Heterophilic exudation was present in the terminal portion of the proventriculus, where the greatest numbers of the organism were found. Megabacteria were present in the mucus covering the mucosal surface and the lumina of the superficial proventricular crypts, occasionally invading the luminal epithelium. Megabacterial infection was in general associated with other diseases such as avian tuberculosis, salmonellosis, coccidiosis, chlamydiosis and various other bacterial and parasitic infections. Only in one hen no other concurrent infectious organism was detected. The turkey had histomoniasis. Wild birds were regarded as probable source of infection, since all affected birds were kept under conditions allowing contact to wild birds and we have diagnosed megabacterial infections in wild-living green finches earlier.

Animals↗
PubMed1999

Liver fluke (Opisthorchiidae) findings in red foxes (Vulpes vulpes) in the eastern part of the Federal State Brandenburg, Germany--a contribution to the epidemiology of opisthorchiidosis.

Parasitological examination of 677 livers from red foxes shot in connection with a rabies control programme were carried out in the eastern districts of the Federal State Brandenburg/Germany in 1996. Of the foxes, 32.5% were positive for opisthorchiid flukes. Metorchis bilis, the most frequently occurring fluke was found in 28.1% of foxes with numbers between 1 and 185. Opisthorchis felineus was found in 6.7% of fox livers. A maximum of 169 specimens was removed from one animal. Pseudamphistomum truncatum was present in only 2 foxes. The percentage of positive foxes in different districts varied between 15.8 and 43.3%. Significant differences in fluke prevalence were found between districts with a high share of surface water compared with a district with a low percentage of surface water. No sex-dependent differences in opisthorchiid prevalence were established.

Animals↗
PubMed1998

Survey on viral pathogens in wild red foxes (Vulpes vulpes) in Germany with emphasis on parvoviruses and analysis of a DNA sequence from a red fox parvovirus.

The seroprevalence of canine parvovirus (CPV), canine distemper virus (CDV), canine adenovirus (CAV) and canine herpesvirus (CHV) infections in red foxes (Vulpes vulpes) was determined in fox sera collected between 1991 and 1995. A total of 500 sera were selected and the seroprevalences were estimated to be 13% (65 of 500 sera) for CPV, 4.4% (17 of 383 sera) for CDV, 35% (17 of 485 sera) for CAV, and 0.4% (2 of 485 sera) for CHV, respectively. No statistically significant differences were observed between the two (rural and suburban) areas under study. Parvovirus DNA sequences were amplified from tissues of free-ranging foxes and compared to those of prototype viruses from dogs and cats. We report here a parvovirus sequence indicative of a true intermediate between the feline panleukopenia virus-like viruses and the canine parvovirus-like viruses. The red fox parvoviral sequence, therefore, appears to represent a link between those viral groups. The DNA sequence together with a significant seroprevalence of parvovirus infections in foxes supports the hypothesis that the sudden emergence of canine parvovirus in the domestic dog population may have involved the interspecies transmission between wild and domestic carnivores.

Adenoviruses, Canine↗
PubMed1985

[Current status of intrathecal antifibrinolytic therapy with p-aminomethylbenzoic acid (PAMBA) in subarachnoid hemorrhages].

The blood-brain barrier is barely affected by slight or moderate subarachnoidal bleeding so that the p-aminomethylbenzoic acid (PAMBA) administered systemically for antifibrinolytic therapy does not attain the continuous level necessary in the cerebrospinal fluid. Thus the antifibrinolytic agent should be applied intrathecally because this would totally inhibit fibrinolytic activity in cerebrospinal fluid containing blood and during the wound healing of ruptured aneurysmas. The improvement in wound healing reduces the occurrence of rebleeding, especially during the first 10 days, and improves conditions for successful surgical intervention.

4-Aminobenzoic Acid↗
PubMed1984

Quantitative determination of valproic acid by means of gas chromatographic headspace analysis.

We have developed a simple but accurate procedure to monitor, by means of gas chromatographic headspace analysis, the concentration of valproic acid (VPA) in serum. Unlike previously described gas chromatographic methods, a preanalytical separation step is unnecessary. Irreversible sample loss, a pitfall in gas chromatographic extraction procedures caused by evaporation during the extraction process of this relatively volatile substance, is avoided. After acidifying and adding internal standard (2- ethylbutanoic acid), the serum sample is sealed hermetically in a special headspace tube. After heating, a vapour phase fraction is injected into the chromatographic column. This method reduces sample preparation time to a few minutes. Analysis time is only three minutes, and the method can easily be automated. Contamination of chromatographic columns by higher molecular mass serum ingredients is avoided.

Chromatography, Gas↗
PubMed1984

Haemostasis in cerebrospinal fluid. Basic concept of antifibrinolytic therapy of subarachnoid haemorrhage.

Among the reasons for intensified research into the CSF haemostatic pathway were the clinical case reports stating that special importance must be attached to the CSF for the high incidence of rebleeding and the intraoperative haemorrhage rate in SAH patients, which, among other things, may be regarded as the reasons for mortality. Extensive analyses of the coagulation and fibrinolysis enzyme systems were carried out and constitute the basic concept for the conservative AFT aiming at restoring to normal haemostasis and wound healing which had been disturbed by local fibrinolytic activity in the area of operation or trauma. The programme of investigation, first served as basic research and was then directed towards the clinical situation for recording the partly contradictory or still unknown haemostasis values in the CSF. This necessitated that the immunochemical, enzymatic, enzymatic-fluorometric, biophysical and chromogenic substrate methods should be adapted to low quantities of protein for the quantitative determination of activators, inhibitors, zymogens, enzymes, the fibrin substrate and its degradation products. The results obtained with the prospective series of tests applying selective methods with objective data recording confirm the operating hypothesis that, on principle, a distinction must be made between the proteins of normal CSF in cases of intact BBB and the pathological protein patterns, not typical of CSF, caused by disturbances of permeation. The CSF space, therefore, must be regarded as a compartment largely insulated by the BBB. That is why the unqualified interpretation is wrong, when it states that the CSF, in general, shows a fibrinolytic activity, no matter whether the CSF is formed under physiological or pathological conditions, or whether it represents a mixture of blood and CSF. CSF formed when the BBB is normal has no fibrinolytic activity. The plasminogen activator antigen always present in CSF does not become effective because the quantity of plasminogen in CSF is well below normal for the measurable fibrinolytic activity. In the case of diseases accompanied by disturbance of the BBB, the proteins of the fibrinolytic system in the CSF increasingly penetrate in proportion to the disturbance of BBB, and thus enable the CSF to some extent to become a fibrinolytically active fluid. A temporarily limited breakdown of the BBB in the case of bleeding into the CSF space permits the unhampered transfer of all the factors required for the fibrinolytic system, as well as the inhibitors.(ABSTRACT TRUNCATED AT 400 WORDS)

Antifibrinolytic Agents↗
PubMed1983

[Late paralysis of the peripheral nerves from the neurologic viewpoint].

In a total of 791 cases of peripheral neuroparalysis, we found 77 cases of late paresis corresponding to approximately 10 per cent of the total number of patients. Almost half the number of late paresis were pareses of the ulnar nerve. The average latency period was 18 years. The causes were: 26 times fractures, 21 times open, sencondarily healed injuries of the soft parts, 14 times irradiation therapy and some closed injuries of the soft parts. Several late pareses occurred after industrial accidents or medical interventions, which may have legal consequences with respect to insurance. The early recognition of late pareses and the consultations in good time of a neurosurgeon for the question of surgical neurolysis is important for the patient because a delay in time may result in irreparable damage of the nerve.

Brachial Plexus↗
PubMed1982

[Coagulation physiological controls in subarachnoid hemorrhages and their therapeutic implications].

Every wound healing of a vascular lesion requires optimum values in an intact coagulation system. The high rate of secondary haemorrhages in subarachnoid haemorrhages induced us to carry out checks of the behaviour of various coagulation parameters. Increases in fibrinogen and reduced thromboplastin time values were the most marked changes of the haemostatic potential. Normal thromboplastin time values are reached by a vitamin K1 therapy.

Blood Coagulation Factors↗
PubMed1982

[Late paralyses of peripheral nerves after radiotherapy].

On the basis of eleven observations in 10 patients carried out by the authors-nine cases of paresis of the brachial plexus, one case of paresis of the accessory nerve and one of femoral nerve--the problems of late paresis due to the irradiation of peripheral nerves are discussed. The development of these nerve lesions are primarily caused by radiation-induced fibroses and vasculopathies in the environment of the nerves. Several series of radiation appear to increase the risk of radiogenic pareses. With the frequently preferred application of megavolt therapy, a further increase in radiogenic nerve lesions may result.

Accessory Nerve↗
PubMed1980

[Fibrinolytic inhibitory proteins of the hemostaseologic system in normal, inflammatory and bloody cerebrospinal fluid].

A quantitative immunochemical determination of the plasmin inhibitors alpha-1-antitrypsin, alpha-2-macroglobulin, and antithrombin-III of the fibronolytic system was carried out from normal, inflammatorily changed, and essentially sanguineous fluids. The low total inhibitor concentration in the cerebrospinal fluid is due to the 'restricted diffusion' caused by the blood/brain barrier function and the lacking synthesis for these proteins in the central nervous system. The inhibitor concentrations which in functional disorders of the blood/sbrain barrier and/or direct entering of blood are still--low as compared to the plasma produce a dissociation of the plasmin-inhibitor complex. The lacking interaction between the active enzyme and the inhibitor enables the occurrence of a free fibrinolytic activity in the cerebrospinal fluid.

Antithrombin III↗
PubMed1980

[Antifibrinolytic therapy of subarachnoid hemorrhage. Permeation of oral paraaminomethylbenzoic acid in the cerebrospinal fluid].

Studies of the permeation of PAMBA in the cerebrospinal fluid of patients with intact or disturbed BBB function after oral administration of 6 g and withdrawal of the spinal fluid after 120 minutes exclusively showed concentrations which were below the identification threshold of the method using 1 micron per millilitre. Patients suffering from subarachnoidal haemorrhages mainly showed a permeation of PAMBA in the cerebrospinal fluid which, however, only rarely reached the lower therapeutically necessary concentration.

4-Aminobenzoic Acid↗