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Biomedical subjects

R Horie

Publications and source records attributed to R Horie.

At least 127 records · Page 7Linked to original sources
PubMed1978

Genetic and environmental modification of spontaneous hypertension.

The further selection of stroke-prone spontaneously rats (SHR) by the grade of hypertension resulted in the separation of substrains with more and less severe hypertension, respectively. Their average tail blood pressures at the age of 100 days were 240 and 200 mmHg. The ratios of cerebral hemorrhage to infarction were markedly decreased from 1/2 in the former into less than 1/30 in the latter. Also a similar attempt separated stroke-resistant SHR into substrains with moderate and mild hypertension; blood pressures at the age of 100 days were 200 and 180 mmHg, respectively. On the other hand, development of severe hypertension was attenuated and the incidence of stroke was significantly reduced in stroke-prone SHR when they were fed on a high-fat-cholesterol diet or a high fish protein diet. The selection of substrains with different grades of hypertension in stroke-prone and stroke-resistant SHR indicates the additional involvement of some hypertension genes, and the alteration of the course and the level of hypertension by nutritional factors substantiates the importance of gene-environment interaction in spontaneous hypertension.

Animals↗
PubMed1978

Glucose tolerance in spontaneously hypertensive rats.

In order to clarify the relationship between essential hypertension and glucose metabolism, and to approach the pathophysiology or the etiology of essential hypertension, we examined glucose tolerance test (GTT) using spontaneously hypertensive rats (SHR) as models. SHR, namely stroke-prone SHR (SHRSP) and stroke-resistant SHR (SHRSR) always had higher serum glucose levels at each GTT phase than normotensive control Wistar-Kyoto rats. They also tended to show higher levels in the young even at 5 weeks of age rather than in the adult. These results indicate that hyperglycemic tendency or lower glucose tolerance may be a characteristic of spontaneous hypertension and may be related to the mechanism of hypertension.

Animals↗
PubMed1978

Glucose metabolism in spontaneously hypertensive rats.

Serum glucose levels in SHR (especially SHR selected for a greater hyperglycemic response) tended to be higher at 'fasting' and were significantly higher after peroral glucose administration than those in normotensive WK. However, plasma immunoreactive insulin was not decreased in SHR as compared with WK. No significant acceleration of gluconeogenesis was observed in SHR.

Animals↗
PubMed1978

Biomembrane characteristics in stroke-prone spontaneously hypertensive rats (SHRSP).

Biomembrane characteristics in stroke-prone SHR (SHRSP) and stroke-resistant SHR (SHRSR) were examined using erythrocytes as a simplified model. When erythrocytes were exposed to osmotic stress in the process of the migration from a higher to a lower osmotic gradient by the coil planet centrifugation, erythrocytes from SHRSP were hemolyzed at a higher osmotic pressure than those from SHRSR. Such a difference in biomembrane characteristics may be useful for detecting a genetic disposition of stroke.

Animals↗
PubMed1978

Genetic subgrouping of stroke-prone SHR and stroke-resistant SHR.

From these results, we can conclude that the developmental pattern of hypertension in the young age is genetically determined and closely related to the incidence of hemorrhage or infarction. These newly selected substrains of SHRSP with higher incidences of cerebral infarction (SP-2) or hemorrhage (SP-1) are regarded as the better models for studying the pathogenesis, treatment, and prevention of infarction or hemorrhage, respectively.

Animals↗
PubMed1978

Cerebral stroke and myocardial lesions in stroke-prone SHR.

1) The histopathological abnormalities of the heart tended to be slightly severer in SHRSP with cerebrovascular lesions than those without cerebrovascular lesions. 2) However, SHRSP without cerebrovascular lesions also indicated abnormalities of VCG and histopathological findings. 3) Therefore, cerebral stroke may not directly affect or engender such myocardial lesions. 4) It is still remained to be solved whether the dysfunction of the heart with organic changes may partially contribute to the occurrence of cerebral stroke. 5) VCG appeared to correspond to the organic changes of the heart.

Animals↗
PubMed1978

Prophylactic trials for stroke in stroke-prone SHR. (3) Amino acid analysis of various diets and their prophylactic effect.

This study confirmed again that high protein diet feeding decreased the incidence of stroke, and high fish protein diet did attenuate severe hypertension but high soybean protein diet did not affect the hypertension. Dietary amino acid analyses indicated that increases in total amino acids, essential amino acids and nonpolar amino acids but not acid or basic amino acids were significantly related to the reduction of stroke incidence. Among essential amino acids, lysine, threonine, isoleucine, and leucine contents were inversely related to stroke incidence, and methionine content was significantly related to the dietary antihypertensive effect of high protein diets. The prophylactic effect of high protein diets may be ascribed to some amino acid constituent.

Amino Acids↗