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R Hosono

Publications and source records attributed to R Hosono.

24 records · Page 2Linked to original sources
PubMed1975

An inhibitory effect of thymidine on its own conversion to nucleotide in Escherichia coli.

The cellular levels of thymidine nucleotide pool in thymine-requiring mutants of Escherichia coli were followed. The pool levels of dTDP, dTTP and compound-X reached maximal values in much lower concentration of thymidine than those in thymine. In higher concentrations of thymidine, an inhibitory effect on its own conversion to nucleotide was observed. The inhibited step was suggested to be the conversion of dTMP to dTDP.

Escherichia coli↗
PubMed1975

Effects of growth conditions on thymidine nucleotide pools in Escherichia coli.

The cellular levels of thymidine nucleotide derived from [3H]thymine or [3H]thymidine were followed under various environmental conditions with a thymine-requiring mutant of Escherichia coli. It was shown that the pool sizes varied greatly with the growth conditions; that is, with growth temperature, inhibition of DNA synthesis of replacement of thymine with thymidine. In the strain used here, the level of compound X, presumably dTDP-sugar, was very much higher than those of other thymidine nucleotides. It is suggested that the conversion of thymine to thymidine is rate-limiting, while the conversions of thymidine to dTMP, and of dTMP to dTDP are more rapid than other steps in the salvage pathway of thymidine nucleotide.

Cytarabine↗