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Biomedical subjects

R Husain

Publications and source records attributed to R Husain.

At least 55 records · Page 3Linked to original sources
PubMed1987

Microbiological diagnosis of suppurative keratitis in Bangladesh.

Experience in setting up an inexpensive microbiology laboratory in the Bangladesh National Society for the Blind Eye Hospital and Training Complex at Chittagong is presented, together with the results of a pilot study to identify organisms responsible in 33 consecutive cases of suppurative keratitis in the Chittagong area of Bangladesh. Of the 33 cases 21 were positively identified by means of Gram stain and/or culture. Two-thirds of the responsible organisms were bacteria, and one-third were fungi. The bacterial causes included Streptococcus pneumoniae and Pseudomonas aeruginosa. The fungi isolated were Aspergillus fumigatus, Aspergillus ochraceus, and Fusarium solani. Among the causes of failure to diagnose the organism was chronicity of infection and previous treatment. The value of the study in the planning of future treatment regimens, and the implications of setting up similar relatively cheap microbiology laboratory facilities in developing countries, are discussed.

Bacteria↗
PubMed1985

Some behavioral effects of early styrene intoxication in experimental animals.

Male albino rats were administered styrene in groundnut oil, PO at doses of 100 mg and 200 mg/kg body weight daily for 14 consecutive days. No neurological deficit was observed in any animal during the course of the experiment. Mean % avoidance response (learning) for each treated group, from day 1 to day 4 of conditioned avoidance response training, revealed a general increase. Styrene significantly increased the % avoidance response at both doses as compared to controls, although no definite dose-response relationship was evident. No significant difference was noted in the spontaneous locomotor activity and regional brain catecholamine levels, between controls and treated rats of either dose. Serotonin levels in hippocampus, hypothalamus, and mid-brain were significantly raised at the higher dose of styrene. Therefore, elevated serotonin levels in these brain regions may account for styrene-induced learning.

Animals↗
PubMed1985

Methyl methacrylate induced behavioural and neurochemical changes in rats.

Methyl methacrylate (MMA), a widely used monomer in the manufacture of acrylic polymers, has been reported to cause neurological deficits in industrial workers. The effect of MMA on regional brain biogenic amines and their correlation with behavioural responses were examined. Male Wistar rats received orally MMA (500 mg/kg body wt) for 21 consecutive days. Our results indicate that MMA markedly impaired locomotor activity and learning, while aggressive behaviour significantly increased. An overall enhancement of biogenic amine levels in pons-medulla and hippocampus was noted. In addition, for noradrenaline an increase in cerebral cortex and corpus striatum, for 5-hydroxytryptamine an increase in mid-brain and hypothalamus and for dopamine a slight decrease in corpus striatum were recorded. The changes in regional brain biogenic amine levels may be partly responsible for altered behaviour.

Aggression↗
PubMed1981

Acrylamide induced inhibition of hepatic glutathione-S-transferase activity in rats.

Rats injected i.p. with acrylamide (50 mg/kg/day) for 5 days showed a significant inhibition of hepatic glutathione-S-transferase (GST) activity; maximum inhibition occurred in 15-day-old rats in which early development of hind limb paralysis was noted. Addition of acrylamide in vitro to the assay system also inhibited GST activity. No changes were observed in oxidized and reduced glutathione contents.

Acrylamides↗
PubMed1980

Effect of styrene on levels of serotonin, noradrenaline, dopamine and activity of acetyl cholinesterase and monoamine oxidase in rat brain.

Oral intubation of styrene (1 ml/kg body weight daily) in adult male albino rats for 15 days produced a significant increase in serotonin and noradrenaline but no change in dopamine contents in brain. The brain of treated animals also showed a significant decrease in monoamine oxidase (MAO) but no change in acetyl cholinesterase (AChE) activity. The neurotoxic effects of styrene may be mediated through alterations in levels of these biogenic amines in the brain tissue.

Acetylcholinesterase↗
PubMed1980

Effect of diethyl maleate on acrylamide induced neuropathy in rats.

Pre-administration of diethyl maleate (DEM) to rats resulted in an earlier onset and development of hind limb paralysis following acrylamide administration than in rats treated with acrylamide only. A marked depletion of brain biogenic amine content and of glutathione levels was also observed in the DEM pretreated groups. Depletion of cellular glutathione would appear to lead to an increased neurotoxicity of acrylamide.

Acrylamides↗
PubMed1977

Effect of manganese on neonatal rat: manganese concentration and enzymatic alterations in brain.

Suckling rats were exposed for 15 and 30 days to manganese through the milk of nursing dams receiving 15 mg MnCl2--4H2O/kg/day orally and after which the neurological manifestations of metal poisoning were studied. No significant differences in the growth rate, developmental landmarks and walking movements were observed between the control and manganese-exposed pups. The metal concentration was significantly increased in the brain of manganese-fed pups at 15 days and exhibited a further three-fold increase over the control, at 30 days. The accumulation of the metal in the brain of manganese-exposed nursing dams was comparatively much less. A significant decrease in succinic dehydrogenase, adenosine triphosphatase, adenosine triphosphatase, adenosine deaminase, acetylcholine esterase and an increase in monoamine oxidase activity was observed in the brain of experimental pups and dams. The results suggest that the developing brain may also be susceptible to manganese.

Acetylcholinesterase↗