Biomedical subjects
Publications and source records attributed to R I Ashurmetov.
It was established that resulting form ultra-violet irradiation of the blood in peritonitis, the pulse increased, diastolic and systolic arterial pressure didn't decreased. The intensity of tissue blood flow increased, especially in the mesentery. This was caused by considerable increase in volumetric blood flow rate in the mesenteric artery.
Peritonitis is still an urgent problem and its solution is determined to a great measure by purposeful studies in the field of pathogenesis and treatment. The creation of adequate models of peritonitis acquires particular significance. Eighty-four animals (dogs) were used to create the model. It is shown in the work that a standard model of generalized peritonitis can be produced by two injections of a polymicrobial suspension consisting of the most commonly encountered peritoneal microbes E. coli and B. fragilis. The suspension is injected into different levels of the abdominal cavity. With this method of administration of the polymicrobial suspension the model was reproduced in 90% of cases. Thus, the developed model resembles human peritonitis in the clinical picture and the laboratory and morphological values.
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Hemosorption permits more rapid and significant decrease in blood plasma concentration of oligopeptides. But at the same time, the decrease in concentration of a number of biogenic amines is noted. Under the influence of ultraviolet irradiation of the autologous blood, the reduction in manifestations of intoxication occurs slower, but norepinephrine production increases, contributing to improvement in the state of systemic hemodynamics and microcirculation.
The goal of the present paper was a comparative study of microcirculation in the peritoneum, mesentery and omentum during the development of experimental peritonitis, as well as the investigation of possible correction of microcirculatory disturbances with the help of hemosorption. It has been established that different degree of microcirculatory disturbances in the tissues under study depended on the duration of peritonitis. Hemosorption recovered microcirculation to initial values, which indicated the reversibility of the disturbances.