PubMed Health⌕ Search

Biomedical subjects

R I Krylova

Publications and source records attributed to R I Krylova.

At least 19 recordsLinked to original sources
PubMed1991

[The chronic course of spontaneous and experimental hepatitis A in rhesus monkeys with viral persistence].

The prolonged (up to 2 years) complex observation of 11 rhesus macaques (Macaca mulatta) with spontaneous hepatitis A and 14 rhesus macaques with experimental hepatitis A developing after their intravenous and/or oral infection with human hepatitis A virus (HAV). Both natural and experimental infection took a chronic course (15-18 months). In 13 monkeys showing morphological changes in the liver during the whole period of the disease elevated enzyme levels in the blood and virus shedding in feces were periodically observed. Only one monkey had acute hepatitis A which lasted 1.5 months. In 11 monkeys the disease took an undulating course with 1-2 relapses when virological, biochemical and morphological signs of the disease could be detected. Seroconversion was observed in all monkeys. Anti-HAV IgM antibodies were retained for not more than 6-7 months and total anti-HAV antibodies, during the whole period of observation. Relapses were found to induce no antibody formation. Evidence on the prolonged (up to 12-16 months) persistence of HAV in primates was obtained for the first time.

Animals↗
PubMed1991

[Comparative morphology of spontaneous hepatitis A in lower Old World monkeys].

Detailed description of liver damage in two species of macaques (rhesus and fascicularis) and green monkeys with spontaneous hepatitis A (HA) induced by the virus similar to human hepatitis. A virus (HAV) is given. Evolution of histological changes was followed by serial liver biopsies. The picture of the hepatitis in the above monkey species resemble that of human NA as well as HA in other monkey species susceptible to HAV. Only in 8 of 21 monkeys the disease lasted for 2-5 months, others exhibited undulating and lingering course which lasted 8-19 months from the beginning of the infection. The lingering course of the infection was caused by HAV persistence in the host with its periodical elimination in faeces.

Animals↗
PubMed1990

Urethral infection of male monkeys by Mycoplasma hominis and Ureaplasma urealyticum.

Seven male Macaca nemestrina, eight male Macaca mulatta and three male Papio hamadrias were infected with M. hominis or U. urealyticum separately or simultaneously into the urethra. Animals of the first two species exhibited moderate infection and mild clinical urethritis characterized by increased number of PMNL in the urethral discharge and colonization and lymphocytic infiltration of the mucous membrane of the urethra and urinary bladder. Animals of the third species proved to be less sensitive.

Animals↗
PubMed1990

[Experimental model of hepatitis A in rhesus monkeys (Macaca mulatta) infected with human hepatitis A virus].

The focus of this paper is characterization of Hepatitis A experimental model obtained for the first time in rhesus monkeys (M. mulatta) infected with fecal isolate from a patient with Hepatitis A (HAV-H1). Monkeys were susceptible to oral and intravenous routes of HAV inoculation. The disease could be reproduced regularly in 4 passages as a result of which HAV strain continuously pathogenic for M. mulatta has been established. All 17 infected monkeys developed Hepatitis A with characteristic (except jaundice) patterns: shedding of virus with the stool, elevations of serum alanine aminotransferase level, appearance of IgM anti-HAV, morphological changes developed in the liver. Our data have demonstrated that the course of experimental Hepatitis A infection in M. mulatta is similar (in many respects) to that observed in man.

Administration, Oral↗
PubMed1990

[The infection of monkeys with Ureaplasma urealyticum serovar VIII].

The possibility of modeling chronic infection on monkeys by the injection of the culture of U. urealyticum, serotype VIII, was shown. The infection of monkeys with these microorganisms introduced in a single intraperitoneal injection resulted in the generalization of the process, which was manifested by the persistence and reproduction of the infective agent in the organs and blood of the animals for as long as 6 months (the term of observation). Lymphoid hyperplasia in the organs of immunogenesis and transitory immunomorphological reaction in the tissues of some organs of the urogenital system were noted. The localization of infective agents in some endocrine glands was not accompanied by disturbances in their function.

Animals↗
PubMed1989

Isolation of M. pneumoniae from monkeys (Presbitus cristata).

Monkeys of the species Presbitus cristata died of severe interstitial pneumonia 20-60 days after their transportation. The carcases were examined for the presence of mycoplasmas. Thirty-six out of 65 samples obtained from the liver, spleen, kidney, lung, lymph nodes, pharynx, bronchi and blood of 13 monkeys contained mycoplasmas biochemically and serologically identical with M. pneumoniae. The isolated strains were able to elicit a rise in body temperature and an elevation in the number of leucocytes in blood as well as development of interstitial pneumonia, colonization of the inner organs by the mycoplasmas and a serological response in the experimentally infected guinea-pigs.

Animals↗
PubMed1988

[Viral hepatitis A in lower Old World monkeys (possibility of use as a model for vaccine testing)].

Morphological, virological and serological data characteristic of spontaneous hepatitis A in macaques and green monkeys have been presented. The disease similar to human hepatitis A was induced in M. iris macaques, with the virus isolated from spontaneously infected rhesus monkeys. Experimental model of hepatitis A in macaques is likely to be used for the testing of vaccines and antiviral preparations.

Animals↗
PubMed1987

[Experimental Mycoplasma infection of the urogenital tract in monkeys].

The possibility of the experimental reproduction of infectious urethritis in monkeys by infecting them with mycoplasma and ureaplasma cultures, newly isolated from human patients, has been shown. In monkeys inoculated with the mixture of mycoplasmas and ureaplasmas, more pronounced infectious urethritis with the symptoms of ascending infection develops. The animals who have had the disease do not develop resistance to repeated infection.

Animals↗
PubMed1977

[Tumors of the liver, biliary tracts and pancreas in monkeys].

The article deals with spontaneous tumours of the liver, biliary tract, and pancreas observed in monkeys of the Sukhumi Simian Nursery during the period of 1960--1974. Among tumours of the liver hepatoadenomas predominated: they were revealed in 4 macaco rhesuses, one green marmoset. In a young baboon hamadryad adenomatous hyperplasia was observed to be developed against the background of hepatocirrhosis. All three cases of tumours of the biliary tract in baboons hamadryad were classified as adenocarcinomas. Descriptions of liver cell anaplastic carcinoma with extensive metastasizing in Macaco rhesus, those of insuloma of the pancreas in the same species, and of papilary duct carcinoma of the head of the pancreas in a red ape (Erythrocebus patas) are presented for the first time. All the monkeys with tumours, but one, were at the age over 10 years and were born in the Nursery, or had been brought to it more than 7 years before.

Adenocarcinoma↗
PubMed1977

[Pathologic anatomy of experimental diseases of small laboratory animals caused by encephalomyocarditis virus (strain EMK-70)].

The results of pathomorphological investigation of the disease in small laboratory animals experimentally induced by the EMC-70 strain of encephalomyocarditis virus isolated from monkeys are presented. Irrespective of the mode of virus injection, the newborn and juvenile mice developed some lesions in the brown fat, transverse-striated muscles, as well as in the brain and heart. In guinea pigs the changes were characterized by the development of severe myocarditis and encephalitis accompanied by viral antigen accumulation. The disease induced by the EMC-70 strain could not be differentiated from the Coxsackie infection by the pathomorphological data. This fact should be taken into consideration in solving some problems pertinent to pathoanatomical diagnosis of viral diseases.

Adipose Tissue, Brown↗
PubMed1976

[Pseudotuberculosis in simians].

Pathologo-anatomic picture of the disease caused by Pasteurella pseudotuberculosis in 20 red monkeys and 2 green marmosets are described. An intestinal form of the infection was observed in the majority of the animals. The main manifestations of pseudotuberculosis in the monkeys were: lesions of the gastro-intestinal tract in the form of grave, occasionally ulcerative enterocolitis; enlargement of the spleen with the presence therein and in the liver of necroses and low granulomatous reaction; enlargement of the lymph nodes, mesenteric in particular, with the characteristic macrophagal reaction in them; impairment of the blood circulation in organs with haemorrhages and necroses, with colonies of microbes in tissues. In the course of bacteriological investigations the pathogen Pasteurella pseudotuberculosis was isolated from the perished animals.

Animals↗