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Biomedical subjects

R I Lifshits

Publications and source records attributed to R I Lifshits.

At least 19 recordsLinked to original sources
PubMed1991

[Characteristics and relationship of mitochondrial and microsomal oxidation processes with various intensities of lipid peroxidation].

Mitochondrial and microsomal oxidation reactions were studied at varying intensities of lipid peroxidation (LPO). The latter were modelled by using thermal burn and combined radiation-thermal injury in animals. It was found that the differences in the intensity and duration of free radical oxidation and LPO reactions may lead to the activation or inhibition of mitochondrial respiration due to the oxidative phosphorylation uncoupling and impaired microsomal and microsomal-mitochondrial intermembrane electron transport and depend on the activities of superoxide dismutase, glutathione reductase and catalase.

Animals↗
PubMed1989

[Analysis of glycosaminoglycans in the blood of patients by the orcinol method].

The blood glycosaminoglycans (GAG) were measured by the orcinol+ method in patients with burns. The orcinol+ reaction was found to depend on the hydrochloric acid concentration in orcinol+ reagent and on the length of the sample incubation. The blood serum GAG levels increase in burn disease, reflecting the severity of the thermal injury.

Burns↗
PubMed1989

[The metabolism of connective tissue biopolymers in burns].

Examined were 66 patients at different stages of the burn disease, and 30 donors. The considerable changes in the exchange of the connective tissue biopolymers in burns, depending on the severity degree of burn trauma were revealed. It is shown, that disorders in the exchange of collagen metabolites retain for a long period after trauma.

Adult↗
PubMed1989

[The reaction to heparin in patients with burn toxemia during extracorporeal detoxification].

The comparison of sensitivity to heparin before hemosorption in burn patients with high level of the blood middle molecular peptides before the operation on the heart in patients with rheumatic cardiac defect without changes in the blood peptide level was carried out. In the model experiments, the influence of a fraction of the middle molecular peptides obtained from the blood of healthy and burned dogs on the effects of heparin and protamine sulfate, and as well on thrombocytic aggregation was studied. The role of the middle molecular peptides in the alteration of response to heparin in burn disease is discussed.

Blood Coagulation↗
PubMed1988

[Blood middle-molecule peptides as factors in the modification of the erythrocyte membrane in burns].

The electrophoretic mobility (EM) and acid stability of erythrocytes were investigated during incubation in a middle-molecule peptide-containing medium and in burns of different severity. It was shown, that EM of erythrocytes markedly increased after thermal injury. Major part of MMP fractions produced the same effect during in vitro incubation. MMP also changed the erythrocyte stability to acid haemolytic.

Animals↗
PubMed1986

[Role of middle-molecule blood peptides in the development of cardiac depression in thermal burns].

Using ultrafiltration and subsequent gel filtration a fraction of middle mass peptides (MMP) possesing cardiodeppressing activity, has been isolated from the blood plasma of dogs exposed to burn injury. In contrast to the corresponding MMP fraction from healthy animal blood, this fraction suppressed contractility of the isolated rat's papillary muscle. Moreover, the active MMP fraction caused an appreciable bradycardia when administered subarachnoidally. The same phenomenon is typical of the corresponding MMP fraction from intact dog's blood, but the rate of bradycardia is significantly lower than that obtained for the fraction from the blood of injured animals. The possibility of local and central-mediated influence of the active fraction on heart functions is discussed. Central-mediated action of the active MMP fraction is confirmed by the ability of other MMP fractions from the blood of injured animals to enhance the blood-brain barrier permeability.

Animals↗
PubMed1977

[Disorder of glycolytic redox in the liver in experimental burn disease].

The authors present the results of studies of the intensity of glycolytic oxidoreduction in the rat liver 3, 6, 12 and 24 days after the reproduction of experimental burn disease. This disease proved to lead to reduction of the glyceral-phosphate dehydrogenase activity and to decrease of 3-phosphoglyceric acid formation in the burned animals' liver, mostly expressed during burn toxemia (the 6th day). The limiting factor of the course of this reaction after the burn was the lack of NAD in the cell. Abnormality of the course of the investigated reaction was one of the reasons for reduced intensity during the glycolytic way of carbohydrate decay as a whole and for decrease of the energetic role of glucose in burn disease.

Animals↗
PubMed1976

[Use of Na1C14 acetate for biosynthesis of serum and organ lipid components in the early periods of experimental myocardial ischemia].

The use of 1C-14 acetate for biosynthesis of lipids and their fractions (cholesterol, phospholipids, triglycerides and nonesterified fatty acids) in the heart, liver, adrenals, lipoid tissue and blood serum was studied in experimental myocardial infarction on the 5th to the 30th day of the experiment. It was concluded that disturbances of lipid metabolism did not always precede myocardial infarction and acute myocardial ischemia could induce changes in lipid metabolism characteristic of atherosclerosis.

Acetates↗
PubMed1975

[Effect of trypsin-like enzyme inhibitor on certain metabolic processes in the acute period of experimental myocardial ischemia].

The effect of trasylol upon the activeness of proteolysis in the cytoplasm and mitochondrial-lysosomal fractions of the heart muscle was studied in the acute experimental period of myocardial ischaemia (5 days) along with a determination of the spectrum of the iso-enzymes of the lactate- and malate- dehydrogenases. For the evaluation of oxidation processes in vitro the iections. Trasylol was found to limit the proteolysis in the cytostructures of the myocardium cell, to increase the activity of the transaminases, as well as to help the normalization of thespectrum of the NAD-dependent iso-enzymes. At the same time, under the effect of the employed drug, the myocardial consumption of the radioactive carbon from the acetate Na-2C-14 increases.

Animals↗