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Biomedical subjects

R I Lynn

Publications and source records attributed to R I Lynn.

24 records · Page 2Linked to original sources
PubMed1979

Resin hemoperfusion for treatment of ethchlorvynol overdose.

Hemoperfusion has been increasingly used to treat drug intoxication. Although efficient extraction rates have been reported with hemoperfusion devices, simultaneous measurements of drug adsorption on the columns and endogenous clearance rates have not been made. We studied three patients who ingested 12 to 22 g of ethchlorvynol (Placidyl). In each patient saline diuresis was induced, and Amberlite XAD-4 resin hemoperfusion was done. Resin extraction of ethchlorvynol was calculated hourly, and the recovery of drugs from each column was measured. Renal clearance of ethchlorvynol was simultaneously measured. The resin removed 100% of perfused ethchlorvynol measured by gas chromatography. Ethchlorvynol recovery from the columns agreed well with calculated extraction. Renal clearance was 1 to 6 mL/min, and estimated metabolic clearance was 16% to 31% of resin extraction rate. Complications included anemia, thrombocytopenia, hypocalcemia, and pancreatitis. Resin hemoperfusion substantially supplements endogenous clearance of ethchlorvynol and is a valuable therapy in ethchlorvynol intoxication.

Adolescent↗
PubMedDate not supplied

Lupus nephropathy as the initial manifestation of systemic lupus erythematosus.

The present report documents the occurrence of lupus nephropathy as the sole initial manifestation of systemic lupus erythematosus (SLE). Despite the absence of initial systemic signs characteristic of SLE, the diagnosis was confirmed on the basis of the renal histopathologic features and serological studies. Subsequent follow-up demonstrated systemic features of the disease in each of the four patients. The report shows that the diagnostic criteria for SLE proposed by the American Rheumatology Association may not be fulfilled at the time of the initial evaluation in all cases, and that some patients may exhibit signs attributable to primary renal disease. These data emphasize the importance of careful assessment of the pattern of glomerular ultrastructural changes and usefulness of appropriate serological studies.

Adult↗