[Comparative evaluation of long-acting nitro preparations in patients with ischemic heart disease and stable angina pectoris of different functional classes].
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Biomedical subjects
Publications and source records attributed to R I Mikunis.
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A prospective epidemiological study was carried out for 10 years at a factory manufacturing computers using an automated information system functioning on the basis of microcomputers CM-1800. The genuine prevalence of cardiovascular diseases and risk factors of their onset was revealed. Methods of early diagnosis of the diseases were suggested, variants of the controlled therapy were elaborated. The study resulted in a decrease of the morbidity with a temporary loss of work fitness because of coronary heart disease, namely from 52.8 days in 1980 to 42.7 days per 100 workers in 1989.
Noninvasive methods (kinetocardiography, pneumotachometry, sphygmomanometry) were used in 32 patients chronic obstructive pulmonary diseases (chronic obstructive bronchitis, bronchial asthma) to study the effect of foridon (calcium antagonist) on the bronchial patency, lesser and greater circulation arterial pressure during single intakes and course treatment. Single intake had no influence on the bronchial patency while it was influenced by course treatment. Foridon reduced the lesser and greater circulation pressure. It is recommended to include foridon in the complex treatment of patients with chronic obstructive pulmonary diseases complicated by pulmonary hypertension.
A study is presented in 59 patients with dilated cardiomyopathy and 41 patients with ischemic heart disease. Diverse changes of the indices of lipid metabolism antioxidant system and metabolism of adenylic nucleotides, data of transesophageal stimulation of the left atrium indicate that these values along with clinical findings are of importance for the differential diagnosis of dilated cardiomyopathy and atherosclerotic myocardial sclerosis.
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Electrocardiography and tetrapolar rheoplethysmography of the finger have demonstrated that voltaren and 5-NK activity produce an adverse action on the coronary blood flow in patients with rheumatoid arthritis. It has been found possible to correct the induced disorders by cordarone.
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Hypotensive effect of foridon was evaluated in 68 patients with first- and second-stage essential hypertension, 17 patients with renal hypertension and 18 patients with pulmonary hypertension. Changes in clinical condition, central hemodynamics, pulmonary arterial systolic pressure, inhalation and exhalation intensity were assessed. Foridon effect was shown to be largely due to reduced peripheral resistance. Foridon (30-60 mg) was effective in first-stage essential hypertension. In second-stage hypertension, foridon alone did not always produce an effect. In such cases, foridon-clofelin combination where clofelin hypotensive effect is enhanced can produce a marked hypotensive effect. Foridon is not indicated for the treatment of renal hypertension. Its use as part of combined treatment for chronic nonspecific pulmonary diseases where it is to reduce pulmonary hypertension, is justified.
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An analysis of primary disability of patients with rheumatoid arthritis (RA) in the Vinnitsa area over the period of 1981-1983 as compared to that of 1971-1973 showed a decrease in its proportion and the improvement of some indices of medical labor examination over the studied period confirming the efficacy of organizational measures in prophylactic medical examination of RA patients in the above area.
The results of a prospective 5-year survey of workers and employees at a computer manufacturing enterprise were summed up. The true prevalence of CHD (11.7% of examinees), arterial hypertension (16.5%), and risk factors of these diseases were established. A scheme of controlled therapy of CHD and arterial hypertension was developed and tested. The annual economic effect of the survey was 4038 rub. per 1000 examinees.
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