Biomedical subjects
R I Rudolph
Publications and source records attributed to R I Rudolph.
Lithium-induced psoriasis of the fingernails.
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Unilateral Schamberg's disease.
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Mid dermal elastolysis.
Mid dermal elastolysis is an exceedingly rare condition. Only three cases have been reported previously. The disease manifests as sharply marginated plaques of fine wrinkles of various size that give the skin an aged appearance. It is characterized histologically by a complete absence of mid dermal elastic fibers and lack of any inflammatory infiltrate. Two new cases are reported, and the other cases are reported.
Vulvar melanosis.
Vulvar melanosis is a condition in which intensely pigmented irregular macules, clinically mimicking malignant melanoma, appear on the vulva. A biopsy specimen shows only marked lower epidermal pigmentation without any melanocytic atypia or nesting. The process is benign, and reassurance is the only treatment.
Haloprogin as treatment for fungal infections.
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Disseminated granuloma annulare treated with low-dose chlorambucil.
Disseminated granuloma annulare (DGA) is a frequently severe chronic and disfiguring disease that is resistant to conventional methods of therapy. In a patient with DGA, low-dose chlorambucil therapy (2 mg three times daily, orally administered) resulted in dramatic and rapid clearing of all lesions in a short period of time. To my knowledge, this is the fourth case reported in which this therapeutic modality was used.
Scabies simulating Darier disease in an immunosuppressed host.
A patient who had recently had renal transplant was on a maintenance regimen of azathioprine and prednisone. She developed a florid, scaling, papular eruption clinically identical to Darler disease. Biopsy specimens and skin scrapings, however, showed a scabietic infestation. We believe that this highly atypical presenation, which had several features found in Norwegian scabies, was due to muted inflammatory response that permitted a great proliferation of the mites.
Physiatrics for deforming linear scleroderma.
When linear scleroderma traverses several joints, severe and mutilating deformities and contractures, with loss of limb function, can result. Drugs and surgical procedures are usually of little benefit in ameliorating the deformities. Physiatrics on the other hand, is a readily available modality than can restore much useful function and reverse the contractures and is probably the most effective means of treating patients with deforming linear scleroderma. This type of therapy should be instituted at the inception of the disease process so that the development and progression of any contraction can be minimized or prevented.
Dermatologic therapy with immunosuppressive agents.
The use of powerful immunosuppressive agents such as methotrexate, cyclophosphamide, and azathioprine in the treatment of serious skin diseases is a relatively recent development whose efficacy is borne out in many studies. Using an immunosuppressant often makes possible an appreciable reduction in dosage of steroid necessary to control disease and, in turn, a reduction in incidence of serious side effects of protracted steroid therapy.
Intraoral psoriasis vulgaris.
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Letter: Piezogenic pedal papules.
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Letter: Inverse tinea versicolor.
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