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Biomedical subjects

R I Samedov

Publications and source records attributed to R I Samedov.

10 recordsLinked to original sources

[Changes in central hemodynamics and microcirculation during laser therapy in patients with coronary insufficiency].

The study was undertaken to examine 45 patients with Stages IIB-III heart failure (HF) by the classification developed by V. Kh. Vasilenko and N. D. Strazhesko. Thirty patients had laser therapy in addition to the routine treatment, 15 patients served as a control group. The combined drug treatment along with laser therapy in patients substantially improved peripheral circulatory parameters than in the controls. There was a positive dynamics of central hemodynamic parameters as shown by lower left ventricular volumes and higher myocardial contractile and pump functions. Improvement of microcirculatory and central hemodynamic parameters in patients treated with laser occurred in earlier periods of hospital stay than in the controls.

Adult↗

[Dynamics of myocardial function in the complex treatment of patients with heart failure using isolated ultrafiltration (polycardiographic data)].

Sixty patients with Stages IIB-III chronic heart failure were examined. The main group included 30 patients on complex therapy involving isolated ultrafiltration (IUF), the other 30 patients who refused to have IUF comprised the control group. The patients from the main group had improvement in the phasic pattern of a cardiac cycle, which was associated with enhanced myocardial contractility and performance due to decreased preload. Improved phasic parameters observed after IUF sessions were sustained in the post-ultrafiltration period and different from those in the control group in which their significant changes were absent during treatment.

Cardiac Glycosides↗

[Central and peripheral hemodynamics in patients with heart failure treated with isolated ultrafiltration (rheographic data)].

A total of 30 patients with Stage IIB-III (by the classification made by V. Kh. Vasilenko and N. D. Strazhesko) heart failure were studied. The preload decrease resulted from isolated ultrafiltration sessions was found to lead to improved central and peripheral hemodynamic parameters, as evidenced by higher cardiac output that caused a reduction of total peripheral vascular resistance. With the multimodality therapy performed in the postultrafiltration period, the reduced total peripheral vascular resistance was followed by diminished edema of parenchymal organs. In the postinfiltration period, the isolated ultrafiltration-induced improvement in peripheral hemodynamic parameters was associated with abundant fluid transition from the interstitial space and with a profound decrease in tissue edema and pressure.

Aged↗

[Functional state of the left regions of the heart in healthy persons during isometric exercise].

Hemodynamic parameters of left and atrial contractile and pump functions were examined in 25 healthy males undergoing leg isometric exercise, by employing echocardiography. Analysis of changes in intracardiac hemodynamics showed that for provision of a marked pressor reaction occurring in healthy persons during isometric exercise, there was enhanced left ventricular myocardial contractility and thereby higher stroke and minute volumes. To maintain the required increase in stroke volume at the maximal exercise level, an accessory mechanism of compensation gears (by the Frank-Starling type), which operates due to myocardial diastolic relaxation, elevated venous blood supply at the expense of sucking cardiac action, and augmented left atrial contractility.

Adult↗

[Changes in fluid spaces in patients with heart failure under the effects of isolated ultrafiltration].

The study was undertaken to examine 22 patients with chronic heart failure of Stages IIB-III according to the classification developed by V. Kh. Vasilenko and N.D. Strazhesko. In patients with severe heart failure accompanied by the edematous syndrome, sessions of isolated ultrafiltration was found to result in substantially lower volumes of circulating plasma, extracellular and interstitial fluids and in increased total protein and hematocrit. When decreased just after each session of isolated infiltration, the volume of circulating plasma increased later due to fluid transfer from the extracellular space into the vascular bed. On day 20 of treatment the volume of circulating plasma reached the baseline values by altering the qualitative composition of plasma.

Aged↗

[Functional status of the left side of the heart in patients with ischemic heart disease during isometric exercise].

Hemodynamic parameters of left-ventricular and left-atrial contractility and pumping function were examined in 47 males with postinfarction cardiosclerosis and no clinical signs of circulatory insufficiency and in 30 normal male subjects, exposed to isometric leg exercise with the highest possible compression force. At the height of exercise, normal subjects showed increased left-ventricular myocardial contractility along with the initiation of the Frank-Starling mechanism, spreading to the left atrium as well, while coronary patients responded to increased stress by growing left-atrial reservoir function during the first minutes of exercise, and activated left-atrial transport and pumping functions afterwards. Isometric leg exercise is capable of detecting left-atrial and left-ventricular pumping and contractility disorders in coronary patients.

Adult↗

[Comparative characteristics of the hemodynamic changes in virtually healthy persons and in ischemic heart disease patients during hand and leg isometric loading].

Comparative studies on changes of hemodynamics in manual and leg isometric loads were conducted in 30 healthy persons and 38 patients with coronary heart disease. A possibility of a leg isometric load with a maximum effort for 5 min. was shown. Intracardiac hemodynamics was estimated by echocardiography results. A possibility to reveal early stages of myocardial contractile and pumping function in patients with coronary heart disease was established. Manual dynamometry does not permit revealing early stages of heart insufficiency.

Coronary Disease↗

[Changes in hemodynamics during isometric loading in healthy subjects].

The hemodynamic response and changes in myocardial contractility during leg isometric exercise with maximal exertion were studied in 30 healthy males. The exercise lasted for 6 to 8 minutes. An analysis of the results showed that the major cause of the increased arterial pressure was an increase in the stroke volume, with the systemic vascular resistance being virtually unaltered. An increased myocardial contractility was shown to be largely responsible for the elevation and the maintenance of the stroke volume at a high level. The prolongation of the sustained isometric exercise was attended by some decrease in the heart rate as compared with the first minutes and the involvement of Frank-Starling mechanism which maintains the stroke volume at the adequate level. The above isometric exercise was associated with no complications, which allows us to consider it safe for patients with heart diseases.

Adult↗

[Changes in hemodynamics during isometric loading in ischemic heart disease].

The hemodynamics and contractility of the myocardium were investigated in 38 men with coronary heart disease using maximal leg isometric load. It was shown that the systemic response to the isometric load in CHD patients unlike in normal subjects was mediated through increased total peripheral resistance rather than through an increase in myocardial contractility and stroke volume. The degree of these changes corresponded to the exercise tolerance as determined by bicycle ergometry. Leg isometric load is an accessible method for evaluating myocardial contractility in CHD which makes it possible to detect its disorders at the earliest stages in functional class I patients.

Adult↗