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Biomedical subjects

R I Wang

Publications and source records attributed to R I Wang.

At least 19 recordsLinked to original sources
PubMed1989

Choice of rating form for evaluating anxiolytics.

The HAM-A has been a popular tool for assessing the anxiety status of patients. However, when studying anxiolytics, HAM-A presents problems. It includes 89 signs and symptoms grouped under 14 major items. Redundant symptoms appear in several items, and different symptoms under the same item may have variable severity, resulting in inconsistent ratings. In addition, evaluation of all 89 symptoms is time consuming and cumbersome, especially when frequent ratings are required in studying patient response to pharmacotherapy. The WARS was specifically designed to quantify symptoms of anxiety for the study of anxiolytics. It contains 12 one-word items, expressing all the relevant and commonly occurring psychic and somatic symptomatology relevant to anxiety. Symptomatology due to medication is rated separately on a side-effect scale. The WARS is thus more sensitive in detecting therapeutic changes. Because of its simplicity and lack of ambiguity, the WARS can be accurately and effortlessly completed in studying anxiolytics.

Anti-Anxiety Agents↗
PubMed1987

Hydrogen peroxide-induced glutathione depletion and aldehyde dehydrogenase inhibition in erythrocytes.

To study relationships between lipid peroxidation and aldehyde dehydrogenase (ALDH) inhibition, the Stocks and Dormandy model of H2O2-induced lipid peroxidation in erythrocytes was employed. Hydrogen peroxide treatment of erythrocytes and erythrocyte lysates caused a dose-dependent inhibition and depletion of ALDH and reduced glutathione (GSH) respectively. Complete ALDH inhibition and glutathione depletion occurred before significant lipid peroxidation was detected by HPLC analysis of malondialdehyde-thiobarbituric acid adducts. Hydroxyl radical scavengers did not antagonize the hydrogen peroxide-induced enzyme inhibition. Studies with the iron chelator desferrioxamine suggested that the hydrogen peroxide-induced ALDH inhibition was mediated by iron in erythrocyte lysates but not in semi-purified (and Chelex-treated) ALDH preparations. Glutathione peroxidase reduction of H2O2 exhibited an anomalous GSH dependence which was not in agreement with the accepted reaction mechanism. Reduced glutathione also antagonized the hydrogen peroxide-induced ALDH inhibition by possible complex formation with the enzyme. A hypothetical model is presented which accounts for the observed responses to hydrogen peroxide.

Aldehyde Dehydrogenase↗
PubMed1979

The clinical analgesic efficacy of oral nefopam hydrochloride.

The analgesic efficacy of 60 and 120 mg nefopam hydrochloride was compared to 650 mg aspirin and placebo in a double-blind single-dose study. Oral doses were administered to 120 patients suffering from acute postsurgical or fracture pain. All active medications demonstrated analgesic activity in comparison to placebo. Patients on 120 mg nefopam obtained the greatest degree of analgesia. Side effects were minor and did not interfere with the course of therapy. The incidence of side effects (sweating, nausea, and lightheadedness) was greater on 120 mg nefopam than on 650 mg aspirin).

Adult↗
PubMed1977

Detection of benzoylecgonine in human urine.

A thin-layer chromatography (TLC) method is described that can be used to detect benzoylecgonine (BE), a metabolite of cocaine, in human urine. It is a two-part procedure that can be integrated into a rapid screening program for drug abuse. The first part of the method utilizes two TLC solvent systems to identify a variety of drugs, including BE. The second part is specific for the cocaine metabolite and can be used as a confirmation method. The procedure is sensitive to 3-4 microgram/ml of BE in urine.

Chromatography, Thin Layer↗
PubMed1977

The safety and value of naloxone as a therapeutic aid.

The safety and value of naloxone as a therapeutic aid was demonstrated in a large population of narcotic dependent persons over a two-year period. Naloxone was used to precipitate the narcotic withdrawal syndrome. This withdrawal syndrome was rated according to a previously developed scale. Retrospectively, naloxone rating scores were correlated with the patients' initial dose of methadone. With patients who received 0.8 mg naloxone, good correlation was obtained between the naloxone test score and the optimum methadone dose (mg), as indicated by the patients' physical status during the initial three days of methadone treatment. Three hundred and sixty-three tests were administered to 343 persons and no individuals developed any serious effects such as convulsions, syncope or cardiovascular collapse.

Adolescent↗
PubMed1977

Determining optimum dose and acute tolerance of triazolam.

The present two-phase study was designed to determine the optimum hynotic dose of triazolam and to assess any evidence of acute tolerance. Subjective and objective data were used to assess hypnotic efficacy. In the dose-titration phase, the dose of triazolam was increased in 0-5 mg increments to the highest level tolerated by each individual patient. Maximum tolerable doses ranged between 0-5 and 3-0 mg; however, all subjects experienced maximum therapeutic effect at 1-5 mg triazolam. During the 4-night acute tolerance portion of the study no clear evidence of tolerance was found.

Adult↗