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R Ia Snigireva

Publications and source records attributed to R Ia Snigireva.

18 recordsLinked to original sources
PubMed1989

[Effectiveness of lysenyl-forte treatment in acromegaly and hyperprolactinemia syndrome].

Lysenyl-forte, a derivative of polysynthetic ergot alkaloids, producing a dopaminergic and antiserotoninergic action was employed to treat acromegaly and prolactin hypersecretion in 11 and 71 patients, respectively. Clinical effect was established basing on a complex of clinical, x-ray, neuro-ophthalmologic and hormonal evidence. Acromegaly treatment proved efficient: 7 patients (63%) showed partial relief of clinical signs, reduced STH blood level. Out of 48 patients with prolactinemia a response was registered in 34 (71%): a more than 50% decrease in prolactin concentration, normal levels of the hormone in 35% of the patients. A menstrual cycle recovered, galactorrhea diminished, 2 women got pregnant. A positive effect was noticed in management of 13 sterile men with prolactin hypersecretion, in 6 patients with idiopathic prolactin hypersecretion, in 4 women with primary hypothyrosis and galactorrhea. Compared to parlodel, lysenyl was not superior in the frequency of side effects, though was inferior in clinical effectiveness. The drug is recommended for wide-scale use.

Acromegaly↗
PubMed1983

[Radioimmunoassay in the evaluation of the hormonal activity of pituitary adenomas].

Direct correlation was found between the results of a radioimmunoassay, electron microscopy and immunohistochemistry in cases of STH-secreting and hormonally inactive hypophyseal adenomas. In hyperprolactinemia and a simultaneous increase in the levels of 2 or more hormones the results of the radioimmunoassay coincided with those of electron microscopy and immunohistochemistry in 50-70% of the cases.

Adenoma↗
PubMed1983

[Proton therapy of pituitary adenomas].

The authors present the results of proton therapy in 59 patients with different hypophyseal adenomas. The period of observation lasted from 6 mos. to 5 yrs. Irradiation was done using a multifield-convergent method and a proton beam of the ITEF synchrotron. The beam energy was 200 MeV, the beam diameter 7-15mm. Radiation response and immediate results were evaluated for all the patients. The least favorable results were noted in the patients with prolactinomas, for which, in addition to irradiation, parlodel therapy is needed. No marked radiation reactions, neurological complications and manifestations of hypopituitarism were observed with the chosen doses and schemes of irradiation.

Adenoma↗
PubMed1982

[Functional morphology of pituitary adenoma in acromegaly].

Twenty-one pituitary adenomas removed from patients with acromegaly were studied electron microscopically. In 9 cases the tumors underwent immunohistochemical analysis by Coons' indirect immunofluorescent technique. Before the operation, all the patients were found by radioimmunoassay to have concentrations of pituitary hormones in the blood serum. A clinico-morphological analysis performed showed that in all cases of acromegaly pituitary adenoma consisted of somatotropocytes differing by the degree of cell granulation. The concentration of the somatotropic hormone (STH) in the blood serum of the patients did not depend on the intensity of the ultrastructural signs of the secretory activity of the cells. In 4 adenomas, a positive immunohistochemical reaction to two hormones, STH and prolactine, was demonstrated.

Acromegaly↗
PubMedDate not supplied

[Dopaminergic regulation of the hypothalamo-hypophyseal system in patients with hypophyseal adenomas].

A study was made of the state of the hypothalamohypophyseal system in patients with different types of chromophobe adenoma. Altogether 62 patients were examined using metoclopramide and Parlodel tests (38 patients were with somatotropinoma, 13--with prolactinoma, 11--with somatotropinoma with hyperprolactinemia). The time course of STH, PRL and TSH secretion in the blood was investigated. Dopaminergic blockade in the Metoclopramide test was shown to cause no change in the time course of PRL secretion in patients with prolactinomas, and a PRL reaction in patients with somatotropinomas and adenomas with PRL and STH hypersecretion was sharply decreased. A paradoxical STH reaction (a decrease) in somatotropinomas and considerable disorders in the type of PRL and TSH secretion in all forms of adenomas was defined in the Parlodel test (a dopaminergic agonist). The results obtained suggest considerable disorders in the dopaminergic regulation of the hypothalamohypophyseal system of patients with chromophobe adenomas and the efficacy of the metoclopramide and Parlodel tests in the differential diagnosis of these conditions.

Adenoma↗
PubMedDate not supplied

[Transnasosphenoidal microsurgery of hypophyseal adenomas].

The results of surgical treatment of 550 patients through a transnasosphenoidal approach are analysed. The results of management of endosellar and endoextrasellar adenomas are discussed. Various groups of patients are set apart according to the hormonal activity of the tumor. The indications and contraindications for operations through a transnasosphenoidal approach are specified beforehand. The complications in transnasal operations are described and mortality is analysed.

Adenoma↗
PubMedDate not supplied

[Status of blood coagulation and various background endocrine indices in patients with basal meningiomas during pre- and postoperative periods].

The condition of blood coagulation activity and the indices of the endocrine background were studied in patients with tumors of prevalently basal localization which caused a direct effect on the central regulating centers. Thirty patients with basal and medially located meningiomas were examined in the pre- and postoperative periods. Before the operation most patients had clinical signs of endocrine-metabolic disorders, often in the presence of an increased content of ACTH and cortisol in the blood. Blood coagulation was disturbed in the majority of patients, mainly due to increased activity of the blood coagulation system. In the postoperative period, blood coagulation activity in 24 of 30 patients was increased or showed a tendency to increase in the presence of elevated blood ACTH content while processes of fibrinolysis were inhibited, which substantiates the necessity for anticoagulant therapy when large doses of glucocorticoids are used.

Adrenocorticotropic Hormone↗
PubMedDate not supplied

[Diagnosis of the functional activity of pituitary adenomas accompanied by hyperprolactinemia].

Comprehensive examination of 24 patients suffering from adenoma of the hypophysis revealed no correlation between the characteristics of computer tomography (the size and density of the tumor, etc) and the level of blood prolactin. Hyperprolactinemia may be encountered both in hormonal active (prolactin secreting) and in hormonal inactive adenoma of the hypophysis.

Adolescent↗
PubMedDate not supplied

[Endocrine disorders in "empty" sella turcica].

The results of endocrine examination of 37 patients with an "empty" sella turcica (22 with primary and 15 with secondary) are discussed. The diagnosis in all cases was verified by the findings of pneumocisternotomography and computer-aided tomography. The trophic function of the hypophysis was mainly studied. It was found that primary "empty" sella turcica mostly occurs in females with a history of many pregnancies. Obesity and disorders of menstrual function were the principal clinical manifestations of endocrine disorders. The inconstantly encountered moderate hyperprolactinemia disappeared after parlodel medication. In secondary "empty" sella turcica hyperprolactinemia was of a more stable character. The trophic function of the hypophysis was reduced in primary "empty" sella turcica as a result of which lesser doses of substitutive hormonal preparations were needed than in secondary "empty" sella turcica. The endocrine disorders in primary "empty" sella turcica were probably of hypothalamic origin, those in a secondary condition were evidently associated with a tumor of the adenohypophysis.

Acromegaly↗
PubMedDate not supplied

[Immunomorphological and ultrastructural characteristics of hypophyseal adenomas in prolactinemia patients].

It was shown by means of electron microscopy and immunohistochemical study that in 11 of 15 patients with high preoperative prolactinemia the tumor consisted mainly of prolactin-containing cells. Small groups of them occurred in the tumors of 2 patients, whereas in 2 other cases prolactin was not detected in the tumor cells by immunohistochemical method. Electron microscopy demonstrated hypophyseal oncocytomas in these 2 cases. Appreciable differences in the blood prolactin concentration, depending on the tumor ultrastructure, were not observed.

Adenoma, Chromophobe↗