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Biomedical subjects

R Iankova

Publications and source records attributed to R Iankova.

7 recordsLinked to original sources
PubMed1989

[Pili anulati].

Report on a 10 year-old girl with pili anulati. Clinical and microscopical findings of that maldevelopment of hair are described. Interestingly, an episodical alopecia totalis and subsequent regrow exhibiting different hair color was observable. Genealogical search confirmed autosomal dominant genetics. The question of expressivity of that dominant gen is discussed.

Alopecia↗
PubMed1989

[Werner's syndrome].

A 33-year-old female has developed Werner's syndrome. The prognosis of the condition is unfavourable because of early symptoms of diabetes and atherosclerosis.

Adult↗
PubMed1984

[Juvenile diabetic cheiroarthropathy].

A 16 years old male is described who was taken ill by diabetes mellitus at the age of 8, treated with insulin, 36 U daily, but with constant poor control of the diabetes. His soft tissues of hands and fingers got thickened in the course of the last several years, with restriction of articular movements and impossible full extent of active and passive extension. No clinical and laboratory data about inflammatory articular process were established. The necessity of a strict control of diabetes is stressed upon, both for the prophylaxis and treatment of juvenile diabetic cheiroarthropathy.

Adolescent↗
PubMedDate not supplied

[The isolation and characteristics of a chemically modified allergen (allergoid) from Dermatophagoides pteronyssinus mites].

Chemically modified allergens (allergoids) were obtained from house dust mites (Dermatophagoides pteronyssinus). The allergenicity of allergoids in comparison with commercial mite allergen was determined by the skin prick test and by the in vitro test of degranulation of passively sensitized rat mast cells. Changes in allergoid molecules were determined with the use of gel filtration in a column packed with Sephadex G-75, isoelectric focusing in polyacrylamide gel, the determination of the concentration of end amino groups and the enzymatic activity of preparations, as well as HPLC. The possibility of using these methods for controlling the process of modification was studied. The results confirmed the fact that the modification on the allergenic preparation really occurred and the allergenic activity of allergoids was low.

Allergens↗