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Biomedical subjects

R Igić

Publications and source records attributed to R Igić.

At least 19 recordsLinked to original sources

Kallikrein and kininases in ocular tissues.

The retina, choroid, ciliary body, iris and aqueous humor of swine eyes contain enzymes capable of producing (kallikrein) and inactivating (kininase I and II) kinins. The activity of the enzymes varies in different eye structures. Higher activities of kallikrein and kininase II were found in highly vascularized tissues such as retina, choroid and ciliary body. The highest activity of kininase I (carboxypeptidase N) was found in the aqueous humor. The presence of these enzymes in the eye structures suggests a possible role for them in local metabolism of vasoactive peptides.

Angiotensin-Converting Enzyme Inhibitors

A simple spectrophotometric method for estimation of plasma angiotensin I converting enzyme activity.

The procedure described is rapid, fairly simple, and inexpensive. The method may easily be used even in a small clinical laboratory. This method, based on a specific reaction which gives a product, hippuric acid azlactone, which absorbs in the visible region, avoids the interference of reagents and solvents encountered in the UV spectrophotometric assay, in which hippuric acid is determined directly.

Animals

Effect of oxotremorine on the acetylcholine content of whole brain and various brain regions in the pigeon.

Oxotremorine (0.125 mg/kg) produces a significant increase in total acetylcholine content in whole pigeon brain. The contribution of different regions to this increase varies. The largest increase occurs in the nucleus basalis (paleostriatum augmentatum), a region which is highly involved in motor control. The mechanism by which oxotremorine increases the acetylcholine content of brain and the causal relationship between the rise in acetylcholine content and tremor are discussed.

Acetylcholine

[Placebos].

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Humans

[Health and smoking].

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Health Education