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Biomedical subjects

R Inaba

Publications and source records attributed to R Inaba.

87 records · Page 5Linked to original sources
PubMed1987

Usefulness of blood parameters, especially viscosity, for the diagnosis and elucidation of pathogenic mechanisms of the hand-arm vibration syndrome.

In the present study it was found that, in vibrating-tool operators with Raynaud's phenomenon, whole blood viscosity was significantly higher than in operators without Raynaud's phenomenon at shear rates from 230 to 11.5 s-1. In addition rats were experimentally exposed to local vibration (60 Hz, 5 g) on their hind limbs for 4 h/d for 30 or 90 d. In the case of 30-d exposure, the small arteries in the exposed site did not change. However, after exposure for 90 d, disruption of the internal elastic lamina was observed in the small arteries. The disruption was followed by focal cell proliferation with regenerative formation of collagen and elastic fibers. The fibro-cellular thickening of the intima was further augmented, and, in addition, a complete stenosis of the small lumen of the small artery was observed. Medial thickness did not show significant differences between the control and exposed groups for either exposure duration. The whole blood viscosity was significantly increased by the 90-d but not by the 30-d exposure. These results suggest that there are some relationships between the increase in whole blood viscosity and the intimal thickening of some small arteries in the exposed site.

Animals↗
PubMed1986

[Changes in the forearm tcPO2 following the cold water immersion test].

The purpose of this study is to apply changes in forearm transcutaneous PO2 (tcPO2) during the cold water immersion test (5 degrees C, for 10 min) to the diagnosis of vibration syndrome. Forearm tcPO2 in healthy controls increased gradually up to 3 min after the start of the cold water immersion and decreased thereafter. It returned to almost the same level before immersion 5 min after the start. In the workers using vibrating tools manifesting Raynaud's phenomenon, forearm tcPO2 also increased up to 3 min after the start as in healthy controls, but no change was observed thereafter. The difference between the level of forearm tcPO2 at 3 min and that at 10 min after the start of the immersion (Forearm tcPO2 recovery index, newly devised by authors) in workers using vibrating tools was significantly lower than that in healthy controls. Therefore, investigation of changes in forearm tcPO2 following the cold water immersion test is considered to be a useful objective item which can contribute to the diagnosis of vibration syndrome.

Aged↗
PubMed1985

Influence of local vibration on plasma creatine phosphokinase (CPK) activity.

This study was designed to obtain basic information about the mechanism of the occurrence of muscular disorders after exposure to vibration. The hind legs of rats were exposed to acute and chronic local vibration at frequencies of 30, 60, 120, 240, 480, and 960 Hz with a constant acceleration of 50 m/sec2. The exposure time was four hours for acute, and four hours a day for two weeks continuously for chronic exposure. Blood was collected after exposure to measure plasma creatine phosphokinase (CPK) activity. In both exposure groups the activity of plasma CPK was significantly higher at 30, 60, 120, 240, and 480 Hz compared with the control group and was especially high at 30 Hz; there was no significant change at 960 Hz. As a result of an analysis of the CPK isoenzymes, the increase in plasma CPK activity was shown to be due to the activity of the plasma CPK-MM fraction, originating in the skeletal muscle. Plasma CPK activity showed a tendency to decrease gradually with the increase in vibration frequency during acute exposure but showed no such tendency during chronic exposure. There was no remarkable pathohistological change in muscle preparations from the hind legs, hence it was presumed that the increase in plasma CPK activity was caused not by the morphological changes of muscle but by other mechanisms, such as an increase in the permeability of the cell membrane.

Animals↗
PubMed1984

A case of hepatocellular carcinoma occurring in a cirrhotic liver--laparoscopically confirmed transition from a cirrhotic nodule to a hepatocellular carcinoma at an interval of 10 months.

Laparoscopy is a very reliable diagnostic procedure for diagnosing hepatocellular carcinoma occurring in the cirrhotic liver. In this paper, the clinical course of a patient, in whom the transition from a cirrhotic nodule to a hepatocellular carcinoma could be detected laparoscopically and bioptically by means of repeated laparoscopic and simultaneous bioptic examinations in an interval of 10 months, is described. Laparoscopy makes it possible to detect a premalignant nodule in the nodular liver.

Carcinoma, Hepatocellular↗
PubMed1984

Laparoscopically disclosed findings of insidious portal hypertension in a hepatitis B surface antigen carrier.

In a 37 year-old male, a chronic asymptomatic carrier, laparoscopic examination disclosed a thickening capsule of the liver with a whitish gray hue and congestive branches of the portal vein scattered on the thickened hepatic capsule. The congestive branches of the portal vein stood out in bold relief against the whitish gray hue and they were suggestive of portal hypertension. The subserosal vein of the gallbladder was also congested and the spleen was enlarged. These findings were related to insidious portal hypertension, though no manifestations of portal hypertension could be detected clinically. Moreover, no early history of liver disease or very few abnormal laboratory findings could be found in this case. The histology of the biopsied liver showed markedly proliferated fibrous tissue, especially in the portal areas, as well as somewhat thick septal formation. To date, many laparoscopic findings of portal hypertension were given, but this is the first report of laparoscopically detected findings in which congested branches of the portal vein were scattered and stood out in bold relief against the thickened hepatic capsule.

Adult↗
PubMed1984

Light microscopic and electron microscopic study on morphologic features resulting in the delay of ICG elimination in diabetic and non-diabetic fatty liver.

Disturbances of intravenously administered indocyanin green (ICG) elimination are related to the effective circulating blood volume and the amount of binding protein for transportation in blood plasma through the liver because of the narrowed sinusoidal space due to the enlarged liver cells with fullness of confluent fat droplets in the cytoplasma. However, morphologic changes of the liver resulting in disturbances of ICG elimination could not be actually clarified until the present. Therefore, morphologic changes of the liver resulting in delayed ICG elimination in fatty liver, occurring in diabetes mellitus were investigated in contrast with those in fatty liver in non-diabetic, non-alcoholic diseases of the liver. An electron microscopic study of the liver with delayed ICG elimination revealed thickening and amorphous growth of the sinusoidal wall with obscure pores followed by membraneous formation, narrowness of Disse's space, rarefaction of sinusoidal microvilli and proliferation of collagen fibers, in fatty livers derived from both diabetes mellitus and other diseases. The term "intrasinusoidal block" in fatty liver should be utilized on the basis of these electron microscopic features of the liver.

Adult↗
PubMed1984

A case of focal fatty change of the liver--a rare clinical entity.

Fatty change of the liver is generally found as a diffuse process involving the entire organ, although it may be accentuated in the central or peripheral portions of the hepatic lobules. We have encountered a case of focal fatty change of the liver which we disclosed incidentally in laparoscopic and bioptic examinations. Focal fatty change of the liver is a rare clinical entity at present which is generally encountered incidentally at postmortem autopsy. Therefore, the clinical course of the patient was described in this paper and the clinical and pathogenetic significance was also discussed.

Adenocarcinoma↗
PubMed1983

Clinical study on latent cirrhosis of the liver.

Although the pathogenesis of liver cirrhosis is complex and not clearly understood, it can be assumed that the morphologic changes in the liver do not occur suddenly in a short space of time and that the morphogenesis goes on insidiously. Therefore, the physician discovers liver cirrhosis coincidentally during evaluation of some other unrelated disease in 20% of cirrhotic patients. Moreover, the diagnosis of liver cirrhosis is established initially at autopsy in 13.5-40% of the patients. The clinical aspect of these cases of latent cirrhosis of the liver was investigated and the patients in this category accounted for 30% of the cases.

Adult↗
PubMed1976

An IgG M-component reacting with both anti-kappa and anti-gamma light chains in multiple myeloma.

A patient with multiple myeloma who has an IgG-IM-component in serum reacting with both kappa and lambda light chains in immunoelectrophoresis is presented. The possibility of "hybrid molecule (H2LkappaLlambda)" is strongly suspected. The absorption studies of the patient's serum employing anti-kappa and anti-lambda light chains, however, support the view that this apparently single M-component consists of two M-components, IgG 1-kappa and IgG 1-lambda. The reason why these two M-components possessed the identical electrophoretic mobility is unclear. The possibility is high that these two M-components are produced in the same cell.

Aged↗