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Biomedical subjects

R Iu Romanova

Publications and source records attributed to R Iu Romanova.

16 recordsLinked to original sources
PubMed1992

[A system of methods of tuberculosis immunodiagnosis based on the use of antigenic preparations isolated from BCG mycobacteria].

The antigenic composition, immunochemical properties and immunogenicity of the antigenic complexes isolated from BCG mycobacteria were studied. A system of sensitive and specific measures of tuberculosis immunodiagnosis has been developed on the basis of specific antigens and antibodies. The informative value of these methods considerably exceeded the previously used test-systems based on the commercial tuberculin.

Antigens, Bacterial↗
PubMed1991

[Polymer-metal complexes of the Mycobacterium protein antigen prevent the dissemination of postvaccinal infection in the T-deficiency state].

Primary obtained triple highly immunogenetic complex consists of nonimmunogenic protein antigen, isolated from the BCG, nontoxic polyelectrolyte and bivalent cuprum ions. Immunization with this complex provides high immunoprotection in the experimented B mice (T-deficit mice) from lethal dissemination BCG. Inoculation of single components of the complex has no protection. Result of these experiments suggest that antigen-polyelectrolyte complexes obtained on the basis of nonimmunogenic protein fraction of the tuberculosis bacilli show the properties of a thymus-independent immunization preparations, and provide immune defense in the T-cell deficit of the immune system.

Animals↗
PubMed1986

[Microbial associations in chronic respiratory tract diseases].

In the peripheral blood of patients with chronic bronchitis the presence of Mycobacterium pneumoniae antigens has been registered in 20.0% of cases and the presence of group A Streptococcus haemolyticus antigens, in 24.0% of cases, the transformation of streptococci into the L-form being observed in 12.0% of cases. The presence of M. pneumoniae, streptococci and their L-forms, as well as associations of these microorganisms, is characteristic of patients with chronic obstructive bronchitis, which is, probably, one of the reasons for the maintenance of bronchial obstruction. In patients with chronic pneumonia and fibrosing alveolitis the antigens of the bacterial form of streptococcus and its L-forms have been detected only in a few cases.

Antibodies, Bacterial↗