VASODILATOR DRUGS IN PERIPHERAL VASCULAR DISEASE.
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Biomedical subjects
Publications and source records attributed to R J BAIRD.
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The changes and improvements in the surgical treatment of aortic valve disease in 296 patients, who were operated on between 1953 and 1965, are illustrated and discussed in general terms. Several of the early techniques, such as transventricular dilation, insertion of a homograft aortic valve in the descending thoracic aorta, fabric replacement of one cusp or the entire valve, and ice-chip arrest of the heart, are now obsolete. Total replacement with a ball-valve prosthesis or an aortic valve homograft while the coronary arteries are perfused with blood is the currently popular technique. The results of a hemodynamic follow-up study two years after surgery are also included.
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The clinical course of 71 patients with esophageal varices who were treated surgically at the Toronto General Hospital in the 17-year period 1947-1964 was reviewed. Forty-five portacaval anastomoses, 19 splenorenal anastomoses and seven transesophageal ligations were performed. The splenorenal shunt was 62% effective and the portacaval shunt 89% effective in preventing further hemorrhage. The end-to-side portacaval shunt was the preferred operation. The overall hospital mortality from a shunting procedure (including emergency procedures) was 17%. The mortality rate was much lower in patients with reasonably normal liver function than in those with elevated serum bilirubin, lowered serum albumin, or refractory ascites. Over 70% of the patients were still alive three years after surgical treatment of the portal hypertension.
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The clinical course of 18 patients with 25 false aneurysms is reviewed. In recent years false aneurysm has been most commonly seen as a complication of arterioplastic procedures in which prosthetic arterial grafts were used. The use of indwelling needles or cannulae, particularly in patients with a wide arterial pulse pressure, can also lead to the formation of false aneurysms. In the groin, a false aneurysm is frequently mistaken for an abscess. Early diagnosis and operative repair are essential to reduce the incidence of further complications.
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The operative and postoperative urinary output of 55 patients who underwent surgery for ruptured abdominal aortic aneurysms, unruptured abdominal aortic aneurysms, and aorto-iliac occlusive disease was recorded. There were five cases of postoperative anuria among 28 patients who received no free fluid in the immediate preoperative period. No case of anuria occurred in 27 patients who received either: (1) a water load of 5% dextrose in water or (2) 20% mannitol solution. The patients who received mannitol had a markedly greater operative and postoperative urinary output.Intravenous infusion of mannitol is recommended during the preoperative and operative period in patients with ruptured aneurysms of the abdominal aorta.
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