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Biomedical subjects

R J Fallon

Publications and source records attributed to R J Fallon.

At least 55 records · Page 3Linked to original sources
PubMed1979

Secretory proteins in the perfused human placenta.

A relatively simple perfusion technique of human placenta has been applied to the study of secretory proteins. Preferential secretion into the maternal circulation of human chorionic gonadotropin (HCG), human chorionic somatomammotropin (HCS), follicle-stimulating hormone (FSH), and placental alkaline phosphatase has been demonstrated, contrasting with the bidirectional secretion of progesterone. Evidence is presented for the net synthesis of HCS during perfusion. The technique offers advantages in the study of synthesis and secretion of placental materials.

Alkaline Phosphatase↗
PubMed1979

Scottish experience with the serologic diagnosis of Legionnaires' disease.

Four-hundred fifty-nine sera from 342 persons were examined at Ruchill Hospital, Glasgow, using an agar-grown heat-killed, ether-treated antigen derived from the Philadelphia 1 strain of the Legionnaires' disease bacterium. They were examined, in parallel, at the Center for Disease Control (CDC), Atlanta. Overall agreement (results agreeing +/- one twofold dilution) was reached with 90% of sera. Important differences were obtained with 10 (2.2%) sera. With three of these 10 sera the CDC alone obtained a significant titre (256) whereas with the other seven the Glasgow laboratory alone obtained a titre of 256. Altogether 28 persons (8.2%) with an agreed titre of 256 or higher were identified. However, some of these people had been ill 4 years before serum was obtained for examination. These persistent high titres make the serologic diagnosis of Legionnaires' disease difficult.

Antibodies, Bacterial↗
PubMed1978

The effect of immunoglobulin levels on calf performance and methods of artificially feeding colostrum to the newborn calf.

A survey of 1,250 purchased calves found that 40% had blood serum Ig values of less than 15 ZST units. A positive relationship was obtained between initial blood serum Ig level of the purchased calf and subsequent mortality. Calf liveweight gain within two systems of calf rearing was not related to initial blood serum Ig levels. No relationship was obtained between initial Ig levels and incidence of diarrhoea. Artificially feeding the newborn calf to appetite with first milking colostrum in two feeds, the first 4-6 hrs after birth and a second 4-6 hrs later results in 95% of calves having blood serum Ig levels greater than 15 ZST units. Artificially feeding the calf colostrum in the presence of the dam resulted in a significant increase in the calf's blood serum Ig level. Artificially feeding colostrum at room temperature (14 degrees C) did not significantly reduce colostrum intake or calf blood serum Ig levels.

Animals↗
PubMed1977

Stool viruses in babies in Glasgow. I. Hospital admissions with diarrhoea.

Stools from 183 babies under 2 years of age admitted to Ruchill Hospital with diarrhoea were examined by electron microscopy, virus culture, bacterial culture and light microscopy. As far as possible, several stools were examined from each patient and the results showed rotaviruses, astroviruses and other viruses in association with symptoms, as well as the expected bacterial pathogens. Examination of several stools from the same patient also showed that in this age group the viral flora of the gut changes rapidly and that the viruses seen by electron microscopy were only rarely grown in cell culture and vice versa. This phenomenon was particularly noted with adenoviruses. In 30% of cases no microbial pathogen was identified and in the remainder the presence of the infecting organism did not always coincide with the symptoms. It is concluded that, with viruses at least, presence of the organism does not constitute proof of causation.

Adenoviruses, Human↗