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Biomedical subjects

R J Finnerty

Publications and source records attributed to R J Finnerty.

18 recordsLinked to original sources
PubMed1981

Specific responses to imipramine and doxepin in psychoneurotic depressed patients with sleep disturbance.

The pretreatment characteristics and symptomatology that were predictive of rapid response to pharmacotherapy (imipramine or doxepin) were determined in 79 psychoneurotic depressed patients with sleep disturbance. Rapid response to treatment was measured as at least a 50% reduction in total score for the Hamilton Rating Scale for Depression after two weeks of treatment. Pretreatment severity of illness and pretreatment scoring of the somatization factor on the Hamilton Rating Scale for Depression and of the self-rating of illness on the Lipman-Rickels Scale were found to be modest predictors of response to either drug. Estimation of imipramine and doxepin response groups was more successful. A higher socioeconomic status and shorter duration of illness were indicative of a favorable response to imipramine, whereas a higher response rate to doxepin was found in male patients. The four group discriminations showed a similarity in pretreatment characteristics between imipramine responders and doxepin non-responders.

Adult↗
PubMed1980

Trazodone in the treatment of neurotic depression.

A double-blind study was conducted to determine the efficacy and safety of trazodone vs. amitriptyline and placebo in 184 patients suffering from neurotic depression. All patients were evaluated for safety and 127 patients who completed 12 to 42 days' therapy were evaluated for efficacy. Trazodone was found to be significantly better than placebo on almost every rating scale, particularly on those items or factors related to depression and associated anxiety. Trazodone was superior to amitriptyline in some patients while amitriptyline was only occasionally better than placebo. Significant improvement was noted in trazodone patients within the first seven days of therapy. Trazodone produced a low level of side effects compared to amitriptyline.

Adolescent↗
PubMed1979

Double-blind study of prochlorperazine, chlordiazepoxide and placebo in psychoneurotic outpatients with dominant symptoms of anxiety.

This was a double-blind study designed to compare 'Compazine', Librium and placebo in a psychoneurotic outpatient population with dominant symptoms of anxiety. The patient participants were accepted for the study when their pre-treatment symptoms of anxiety met a minimum or greater score on the Hamilton Anxiety Rating Scale. The study interval was 4 weeks. Patient psychopathology was rated by the treating physician on the Hamilton Anxiety Rating Scale, the New Physician Rating List and Global Evaluation. Patients completed the Self-Rating Symptom Scale and the Profile of Mood States. All efficacy criteria ranked the study medications in the same order. Prochloroperazine was most effective, chlordiazepoxide was also active and placebo was least effective. There are statistically significant active medication versus placebo comparisons supporting desirable drug action. Chlordiazepoxide versus placebo comparisons approached statistical significance for all efficacy criteria.

Anxiety↗
PubMed1979

Comparative efficacy of tofisopam and placebo.

Tofisopam is a new agent marketed in Europe as a minor tranquilizer. The authors conducted a 4-week double-blind trial of this drug compared with placebo in 57 outpatients with anxiety and depression. They found that according to physician ratings and patient self-ratings tofisopam was an effective anxiolytic agent for subjects with anxiety and depression. Twenty-one percent of the patients receiving tofisopam and 10% of those receiving placebo reported side effects. The drug was especially effective in the treatment of somatic difficulties.

Anti-Anxiety Agents↗
PubMed1979

The comparative efficacy of buspirone and diazepam in the treatment of anxiety.

In this double-blind study, 56 adult psychoneurotic outpatients with a primary diagnosis of anxiety neurosis were randomly assigned to receive buspirone (N = 18), diazepam (N = 20), or placebo (N = 18) over a four-week period. A battery of tests administered weekly indicated that buspirone, a new agent not chemically related to any currently marketed drugs, was as effective an antianxiety agent as diazepam and produced no more and perhaps fewer side effects. Buspirone showed excellent antidepressant effects as well. If further studies confirm the authors' findings and determine that buspirone does not result in tolerance and addiction, it would be more advantageous than the benzodiazepines in the treatment of anxiety.

Adult↗
PubMed1978

Doxepin versus imipramine in psychoneurotic depressed patients with sleep disturbance: a double-blind study.

This double-blind randomized study compared the effects of imipramine (48 patients) and doxepin (49 patients) in psychoneurotic depressed patients with sleep disturbance symptoms. Mean doses of 112.7 mg/day for doxepin and 116.7 mg/day for imipramine were administered for a mean period of 26 days. While both drugs proved effective, 24 of 27 analyses of covariance showed imipramine to be superior to doxepin. This superiority was statistically significant for the anxiety/depression factor measured on the Hamilton Depression Scale and for the total score, general neurotic feelings factor, cognitive performance difficulty factor and anger-hostility cluster on the Lepman-Rickels Scale. Mild-to-moderate side effects were prevalent to a comparable degree in both treatment groups.

Adjustment Disorders↗
PubMed1977

Which tricyclic for depressed outpatients, imipramine pamoate or amitriptyline?

Fifty-seven neurotically depressed outpatients with sleep disturbance were randomly assigned to treatment with either imipramine pamoate or amitriptyline given in a single dose at bedtime in a double-blind study for four weeks. The results indicate that both imipramine pamoate and amitriptyline are equally effective in treating neurotic depression. The clinical lore that imipramine is more effective for retarded depression and amitriptyline for anxious, agitated depression was not supported by this study. Of special interest is the fact that the imipramine pamoate group had significantly earlier rising times, and a trend toward better quality of sleep. The side effect profiles of the two drugs were also remarkably similar in this population though more patients complained of side effects on amitriptyline than on imipramine.

Adjustment Disorders↗