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Biomedical subjects

R J Glavin

Publications and source records attributed to R J Glavin.

4 recordsLinked to original sources

Atracurium--a post-marketing surveillance study: U.K. study and discussion.

Two companion post-marketing studies have evaluated the frequency of adverse events amongst patients receiving atracurium. In this second report, we describe the Scottish study and discuss findings in both centres. In this study we compare the frequency of adverse events in 477 patients receiving atracurium with those in 484 patients who received vecuronium. The frequency of reported serious adverse events was low during surgery and in the recovery room. Although the overall incidence of adverse experiences was slightly lower after atracurium, there were no significant difference between the groups in frequency of major adverse events. This type of study is believed to be of value in the future surveillance of new drugs for hospital use.

Anesthesia Recovery Period

Assessing collateral circulation in the hand--four methods compared.

Four ways to assess the collateral circulation in the hand were compared. No correlation was shown between the Doppler ultrasound method and those that used either the pulse monitor or the Ohmeda Biox 3700 pulse oximeter. The study was unable to confirm suggested benefits of these methods in assessing adequacy of collateral flow in the hands of unconscious patients.

Collateral Circulation

Ibuprofen in the management of postoperative pain.

The effect of the regular administration of ibuprofen on pain following abdominal surgery was investigated in a double-blind placebo-controlled study. The analgesic action of ibuprofen was measured by a reduction in the amount of morphine self-administered from an On-Demand Analgesic Computer. Pain scores, nausea scores and blood loss were similar in both groups, but patients receiving ibuprofen demanded significantly less morphine in the 24 h after surgery.

Adult

Patient-controlled analgesia. Experience of two new machines.

Two modern patient-controlled analgesia pumps have been evaluated in the laboratory and in clinical use. Both machines generally performed satisfactorily and patients achieved good pain relief from self-administered morphine. The relative merits of the two pumps are discussed and although the on demand analgesic computer is preferred, a substantial investment of time on the ward is required to provide continuous patient-controlled analgesia.

Equipment Design