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Biomedical subjects

R J Griep

Publications and source records attributed to R J Griep.

10 recordsLinked to original sources
PubMed1990

Staging non-small cell carcinoma of the lung using technetium-99m-labeled monoclonal antibodies.

A technetium-labeled monoclonal antibody was administered to 52 patients with non-small cell lung carcinoma, either to stage the mediastinum preoperatively or to detect distant metastases. Results from planar and tomographic imaging are compared to CT and histologic confirmation. Differences in detection rates and predictive values between imaging modalities are discussed. The authors conclude that imaging with a technetium-labeled monoclonal antibody is safe and accurate and may be useful for staging patients with either operable or inoperable non-small cell lung cancer.

Adult↗
PubMed1980

Behavioral dysfunction in hyperthyroidism. Improvement with treatment.

We measured behavioral dysfunction in hyperthyroid patients to determine if improvement occurred with therapy. The Sickness Impact Profile (SIP), an interview designed to measure sickness-related behavior, was administered to 14 hyperthyroid patients on initial diagnosis and at intervals during treatment. All patients received medical therapy (propranolol hydrochloride, propylthiouracil, and/or radioactive iodine) and showed both biochemical improvement as measured by adjusted serum thyroxine (T4) levels and functional improvement as measured by the SIP score. Patients were less productive during the day and required naps and rest. Although they were irritable, critical, and demanding in their family and social interactions, they were not less affecionate, isolated, or less interested in others. Altered sleep and rest patterns may have been responsible for disrupting normal daily activities. Treating the underlying metabolic disorder resulted in a relatively prompt resolution of the patients' dysfunctional behavior.

Adolescent↗
PubMed1977

Gallium-67 scanning at 6 hr in active inflammatory bowel disease: case report.

Gallium citrate scanning at 6 hr was used to evaluate a patient with active ulcerative colitis. The localization of 67Ga in the colon correlated with the extent of the inflammatory process. When either colonoscopy or radiographic contrast studies are contraindicated, 67Ga scanning at 6 hr may prove useful in the evaluation of active inflammatory bowel disease.

Colitis, Ulcerative↗
PubMed1975

Long-term therapy for chronic bacteriuria in men. U.S. Public Health Service cooperative study.

Response to therapy, renal function, and mortality were analyzed in a prospective study of 249 men with bacteriuria followed for up to 10 years. All patients received initial organism-specific antibiotic therapy followed by 2 years of continuous treatment with sulfamethizole, nitrofurantoin, methenamine mandelate, or placebo. Continuous therapy with active drugs delayed recurrence of bacteriuria and reduced acute clinical exacerbations of infection. Patients with pure Escherichia coli bacteriuria, normal intravenous pyelogram, no previous therapy, and a normal prostate had a good prognosis with short-term antibiotic therapy alone. The presence of prostatic or upper urinary tract calculi, pyelonephritic scars, or mixed or enterococcal infections predicted a poor bacteriologic prognosis. In the absence of severe urologic disease or concomitant noninfectious renal disease no patients with persistent bacteriuria developed renal failure. Continuous antibiotic therapy is of value in selected male patients with bacteriuria in reducing recurrence and acute clinical exacerbations of urinary tract infection.

Adult↗